HUMAN:AMD

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	PAM
Protein Name(s)	Peptidyl-glycine alpha-amidating monooxygenase PAM Peptidylglycine alpha-hydroxylating monooxygenase PHM Peptidyl-alpha-hydroxyglycine alpha-amidating lyase Peptidylamidoglycolate lyase PAL
External Links
UniProt Identifier	AMD_HUMAN
UniProt Accessions	P19021, A6NMR0, A8K293, O95080, Q16252, Q16253, Q54A45, Q86U53, Q8WVC7, Q9UCG0,
EMBL	M37721, S75037, S75038, AB095007, AK290158, BT007419, AC008779, AC010250, AC113373, CH471086, BC018127, AF010472,
PIR	A35477,
RefSeq	NP_000910.2, NP_001170777.1, NP_620121.1, NP_620176.1, NP_620177.1,
IntAct	P19021,
Ensembl	ENST00000304400, ENST00000438793,
Pfam	PF01082, PF01436,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0004598	peptidylamidoglycolate lyase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:4.3.2.5	F
	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014783	F
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0030141	stored secretory granule	PMID:7999037^[1]	NAS: Non-traceable Author Statement		C
	GO:0031418	L-ascorbic acid binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0847	F
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000720	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0005507	copper ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000720	F
	GO:0005515	protein binding	PMID:9837933^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O75901	F
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005507	copper ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000323	F
	GO:0006518	peptide metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000720	P
	GO:0016829	lyase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0456	F
	GO:0004497	monooxygenase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000323	F
	GO:0004497	monooxygenase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0503	F
	GO:0003824	catalytic activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	F
	GO:0009987	cellular process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008977	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008977	F
	GO:0006464	protein modification process	PMID:2357221^[3]	TAS: Traceable Author Statement		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014783	P
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0006518	peptide metabolic process	PMID:7999037^[1]	NAS: Non-traceable Author Statement		P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000720	P
	GO:0004504	peptidylglycine monooxygenase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000720	F
	GO:0004504	peptidylglycine monooxygenase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.14.17.3	F
	GO:0004504	peptidylglycine monooxygenase activity	PMID:7999037^[1]	NAS: Non-traceable Author Statement		F
	GO:0004504	peptidylglycine monooxygenase activity	PMID:2357221^[3]	TAS: Traceable Author Statement		F
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	P
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008977	F
	GO:0003824	catalytic activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	F
	GO:0004497	monooxygenase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000323	F
	GO:0004497	monooxygenase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0503	F
	GO:0004504	peptidylglycine monooxygenase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000720	F
	GO:0004504	peptidylglycine monooxygenase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.14.17.3	F
	GO:0004504	peptidylglycine monooxygenase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	F
	GO:0004504	peptidylglycine monooxygenase activity	PMID:2357221^[3]	TAS: Traceable Author Statement		F
	GO:0004504	peptidylglycine monooxygenase activity	PMID:7999037^[1]	NAS: Non-traceable Author Statement		F
	GO:0004598	peptidylamidoglycolate lyase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:4.3.2.5	F
	GO:0004598	peptidylamidoglycolate lyase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	F
	GO:0005507	copper ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000323	F
	GO:0005507	copper ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000720	F
	GO:0005507	copper ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	F
	GO:0005515	protein binding	PMID:9837933^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O75901	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005624	membrane fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	C
	GO:0006464	protein modification process	PMID:2357221^[3]	TAS: Traceable Author Statement		P
	GO:0006518	peptide metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000720	P
	GO:0006518	peptide metabolic process	PMID:7999037^[1]	NAS: Non-traceable Author Statement		P
	GO:0007417	central nervous system development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	P
	GO:0007507	heart development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	P
	GO:0008152	metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0511	P
	GO:0009268	response to pH	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	P
	GO:0009987	cellular process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008977	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000720	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F
	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000323	F
	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008977	F
	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014783	F
	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014784	F
	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020611	F
	GO:0016829	lyase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0456	F
	GO:0030141	stored secretory granule	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	C
	GO:0030141	stored secretory granule	PMID:7999037^[1]	NAS: Non-traceable Author Statement		C
	GO:0031418	L-ascorbic acid binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0847	F
	GO:0032355	response to estradiol stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	P
	GO:0043204	perikaryon	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	C
	GO:0046688	response to copper ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0051384	response to glucocorticoid stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000323	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000720	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008977	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014783	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014784	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020611	P
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P
	GO:0060173	limb development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000046774	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Tateishi K et al. (1994) Isolation and functional expression of human pancreatic peptidylglycine alpha-amidating monooxygenase. Biochem Biophys Res Commun 205: 282-90 PubMed GONUTS page
↑ ^2.0 ^2.1 Chen L et al. (1998) P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. J Biol Chem 273: 33524-32 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Glauder J et al. (1990) Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells. Biochem Biophys Res Commun 169: 551-8 PubMed GONUTS page

[PMID:7999037-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Tateishi K et al. (1994) Isolation and functional expression of human pancreatic peptidylglycine alpha-amidating monooxygenase. Biochem Biophys Res Commun 205: 282-90 PubMed GONUTS page

[PMID:9837933-1] 2.0 ^2.1 Chen L et al. (1998) P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. J Biol Chem 273: 33524-32 PubMed GONUTS page

[PMID:2357221-2] 3.0 ^3.1 ^3.2 ^3.3 Glauder J et al. (1990) Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells. Biochem Biophys Res Commun 169: 551-8 PubMed GONUTS page

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HUMAN:AMD

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