HUMAN:ALDH2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	ALDH2 ( synonyms: ALDM )
Protein Name(s)	Aldehyde dehydrogenase, mitochondrial ALDH class 2 ALDH-E2 ALDHI
External Links
UniProt Identifier	ALDH2_HUMAN
UniProt Accessions	P05091, Q03639, Q6IB13, Q6IV71,
EMBL	X05409, Y00109, M20456, M20444, M20445, M20446, M20447, M20448, M20449, M20450, M20451, M20452, M20453, M20454, AY621070, CR456991, BC002967, BC071839, K03001, M26760, M54931,
PIR	A29975,
RefSeq	NP_000681.2, NP_001191818.1,
PDB	1CW3, 1NZW, 1NZX, 1NZZ, 1O00, 1O01, 1O02, 1O04, 1O05, 1ZUM, 2ONM, 2ONN, 2ONO, 2ONP, 2VLE, 3INJ, 3INL, 3N80, 3N81, 3N82, 3N83,
IntAct	P05091,
Ensembl	ENST00000261733,
Pfam	PF00171,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016160	F
	GO:0071398	cellular response to fatty acid	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001816	P
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015590	P
	GO:0006805	xenobiotic metabolic process	Reactome:REACT_13705	TAS: Traceable Author Statement		P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016160	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016162	P
	GO:0006805	xenobiotic metabolic process	Reactome:REACT_13433	TAS: Traceable Author Statement		P
	GO:0004029	aldehyde dehydrogenase (NAD) activity	Reactome:REACT_1080	TAS: Traceable Author Statement		F
	GO:0007268	synaptic transmission	Reactome:REACT_13685	TAS: Traceable Author Statement		P
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001816	C
	GO:0033574	response to testosterone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001816	P
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016161	F
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015590	P
	GO:0006069	ethanol oxidation	Reactome:REACT_34	TAS: Traceable Author Statement		P
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015590	F
	GO:0005759	mitochondrial matrix	Reactome:REACT_1080	TAS: Traceable Author Statement		C
	GO:0055093	response to hyperoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001816	P
	GO:0042136	neurotransmitter biosynthetic process	Reactome:REACT_13583	TAS: Traceable Author Statement		P
	GO:0042802	identical protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001816	F
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016163	P
	GO:0005975	carbohydrate metabolic process	PMID:8903321^[1]	TAS: Traceable Author Statement		P
	GO:0032496	response to lipopolysaccharide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001816	P
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016160	P
	GO:0004029	aldehyde dehydrogenase (NAD) activity	PMID:1306115^[2]	TAS: Traceable Author Statement		F
	GO:0004029	aldehyde dehydrogenase (NAD) activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.2.1.3	F
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P
	GO:0032570	response to progesterone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001816	P
	GO:0004029	aldehyde dehydrogenase (NAD) activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001816	F
	GO:0035094	response to nicotine	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001816	P
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000031411	C
	GO:0005759	mitochondrial matrix	Reactome:REACT_15407	TAS: Traceable Author Statement		C
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016162	P
	GO:0004030	aldehyde dehydrogenase (NAD(P)+) activity	PMID:8903321^[1]	TAS: Traceable Author Statement		F
	GO:0032870	cellular response to hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001816	P
	GO:0006066	alcohol metabolic process	PMID:1306115^[2]	TAS: Traceable Author Statement		P
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016161	P
	GO:0007268	synaptic transmission	Reactome:REACT_13477	TAS: Traceable Author Statement		P
	GO:0009055	electron carrier activity	PMID:8903321^[1]	TAS: Traceable Author Statement		F
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016162	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016163	F
	GO:0005759	mitochondrial matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0170	C
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016161	P
	GO:0001889	liver development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001816	P
	GO:0004029	aldehyde dehydrogenase (NAD) activity	Reactome:REACT_15407	TAS: Traceable Author Statement		F
	GO:0004029	aldehyde dehydrogenase (NAD) activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.2.1.3	F
	GO:0004029	aldehyde dehydrogenase (NAD) activity	PMID:1306115^[2]	TAS: Traceable Author Statement		F
	GO:0004029	aldehyde dehydrogenase (NAD) activity	Reactome:REACT_1080	EXP: Inferred from Experiment		F
	GO:0004029	aldehyde dehydrogenase (NAD) activity	Reactome:REACT_15407	EXP: Inferred from Experiment		F
	GO:0004030	aldehyde dehydrogenase (NAD(P)+) activity	PMID:8903321^[1]	TAS: Traceable Author Statement		F
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0005759	mitochondrial matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0170	C
	GO:0005759	mitochondrial matrix	Reactome:REACT_1080	TAS: Traceable Author Statement		C
	GO:0005759	mitochondrial matrix	Reactome:REACT_15407	TAS: Traceable Author Statement		C
	GO:0005975	carbohydrate metabolic process	PMID:8903321^[1]	TAS: Traceable Author Statement		P
	GO:0006066	alcohol metabolic process	PMID:1306115^[2]	TAS: Traceable Author Statement		P
	GO:0006069	ethanol oxidation	Reactome:REACT_34	TAS: Traceable Author Statement		P
	GO:0006805	xenobiotic metabolic process	Reactome:REACT_13433	TAS: Traceable Author Statement		P
	GO:0006805	xenobiotic metabolic process	Reactome:REACT_13705	TAS: Traceable Author Statement		P
	GO:0007268	synaptic transmission	Reactome:REACT_13477	TAS: Traceable Author Statement		P
	GO:0007268	synaptic transmission	Reactome:REACT_13685	TAS: Traceable Author Statement		P
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015590	P
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016160	P
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016161	P
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016162	P
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016163	P
	GO:0009055	electron carrier activity	PMID:8903321^[1]	TAS: Traceable Author Statement		F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015590	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016160	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016161	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016162	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016163	F
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F
	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016163	F
	GO:0042136	neurotransmitter biosynthetic process	Reactome:REACT_13583	TAS: Traceable Author Statement		P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015590	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016160	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016161	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016162	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016163	P
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Xiao Q et al. (1996) The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J Clin Invest 98: 2027-32 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Yoshida A (1992) Molecular genetics of human aldehyde dehydrogenase. Pharmacogenetics 2: 139-47 PubMed GONUTS page

[PMID:8903321-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Xiao Q et al. (1996) The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J Clin Invest 98: 2027-32 PubMed GONUTS page

[PMID:1306115-1] 2.0 ^2.1 ^2.2 ^2.3 Yoshida A (1992) Molecular genetics of human aldehyde dehydrogenase. Pharmacogenetics 2: 139-47 PubMed GONUTS page

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HUMAN:ALDH2

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