HUMAN:AKT2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	AKT2
Protein Name(s)	RAC-beta serine/threonine-protein kinase Protein kinase Akt-2 Protein kinase B beta PKB beta RAC-PK-beta
External Links
UniProt Identifier	AKT2_HUMAN
UniProt Accessions	P31751, B2RBD8, Q0VAN1, Q68GC0,
EMBL	M77198, M95936, AK314619, BC120994, AY708392,
PIR	A46288,
RefSeq	NP_001617.1,
PDB	1GZK, 1GZN, 1GZO, 1MRV, 1MRY, 1O6K, 1O6L, 1P6S, 2JDO, 2JDR, 2UW9, 2X39, 2XH5, 3D0E, 3E87, 3E88, 3E8D,
IntAct	P31751,
Ensembl	ENST00000392038, ENST00000424901,
Pfam	PF00169, PF00069, PF00433,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005829	cytosol		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0005524	ATP binding		IEA		F	Source: InterPro
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0004674	protein serine/threonine kinase activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0006468	protein amino acid phosphorylation		IEA		P	Source: InterPro
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017892	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	F
	GO:0004674	protein serine/threonine kinase activity	PMID:1409633^[1]	TAS: Traceable Author Statement		F
	GO:0005080	protein kinase C binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	F
	GO:0005515	protein binding	PMID:10490823^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UKG1	F
	GO:0005515	protein binding	PMID:12176997^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q16543	F
	GO:0005515	protein binding	PMID:12434148^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P49841	F
	GO:0005515	protein binding	PMID:16417406^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P55160	F
	GO:0005515	protein binding	PMID:17030088^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UKG1	F
	GO:0005515	protein binding	PMID:17535800^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q7Z6J0	F
	GO:0005515	protein binding	PMID:17577629^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q15047	F
	GO:0005515	protein binding	PMID:19713527^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4K3	F
	GO:0005515	protein binding	PMID:20059950^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P53804	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017892	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005524	ATP binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	F
	GO:0005625	soluble fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	C
	GO:0005634	nucleus	PMID:20059950^[10]	IDA: Inferred from Direct Assay		C
	GO:0005654	nucleoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	C
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	C
	GO:0005792	microsome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	C
	GO:0005829	cytosol	Reactome:REACT_1622	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6725	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_6952	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_908	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	C
	GO:0006464	protein modification process	PMID:1409633^[1]	TAS: Traceable Author Statement		P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017892	P
	GO:0006468	protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0006970	response to osmotic stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0008286	insulin receptor signaling pathway	PMID:16814735^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0008286	insulin receptor signaling pathway	Reactome:REACT_498	TAS: Traceable Author Statement		P
	GO:0009967	positive regulation of signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0010628	positive regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport	PMID:16814735^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0010765	positive regulation of sodium ion transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0010907	positive regulation of glucose metabolic process	PMID:16814735^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0014850	response to muscle activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016301	kinase activity	Reactome:REACT_6725	TAS: Traceable Author Statement		F
	GO:0016301	kinase activity	Reactome:REACT_6952	TAS: Traceable Author Statement		F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016310	phosphorylation	Reactome:REACT_6725	TAS: Traceable Author Statement		P
	GO:0016310	phosphorylation	Reactome:REACT_6952	TAS: Traceable Author Statement		P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0030027	lamellipodium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000103981	C
	GO:0030335	positive regulation of cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0031982	vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	C
	GO:0032000	positive regulation of fatty acid beta-oxidation	PMID:16814735^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0032593	insulin-responsive compartment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	C
	GO:0032868	response to insulin stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0032869	cellular response to insulin stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0032869	cellular response to insulin stimulus	PMID:16814735^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0032870	cellular response to hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0033119	negative regulation of RNA splicing	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0043154	negative regulation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0043491	protein kinase B signaling cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0045725	positive regulation of glycogen biosynthetic process	PMID:16814735^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0046326	positive regulation of glucose import	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0046326	positive regulation of glucose import	PMID:16814735^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0046328	regulation of JNK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000103981	P
	GO:0050927	positive regulation of positive chemotaxis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:0070887	cellular response to chemical stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000025303	P
	GO:2000147	positive regulation of cell motility	PMID:17332325^[12]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Cheng JQ et al. (1992) AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci U S A 89: 9267-71 PubMed GONUTS page
↑ Mitsuuchi Y et al. (1999) Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 18: 4891-8 PubMed GONUTS page
↑ Basso AD et al. (2002) Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 277: 39858-66 PubMed GONUTS page
↑ Yang J et al. (2002) Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol 9: 940-4 PubMed GONUTS page
↑ Weiner OD et al. (2006) Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol 4: e38 PubMed GONUTS page
↑ Nechamen CA et al. (2007) APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. Mol Cell Endocrinol 260-262: 93-9 PubMed GONUTS page
↑ Lyons TR et al. (2007) Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. J Biol Chem 282: 21987-97 PubMed GONUTS page
↑ Gao H et al. (2007) Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression. Mol Cell Biochem 305: 35-44 PubMed GONUTS page
↑ Yang WL et al. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325: 1134-8 PubMed GONUTS page
↑ ^10.0 ^10.1 Suizu F et al. (2009) The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell 17: 800-10 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Bouzakri K et al. (2006) siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab 4: 89-96 PubMed GONUTS page
↑ Cheng GZ et al. (2007) Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res 67: 1979-87 PubMed GONUTS page

[PMID:1409633-0] 1.0 ^1.1 Cheng JQ et al. (1992) AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci U S A 89: 9267-71 PubMed GONUTS page

[PMID:10490823-1] Mitsuuchi Y et al. (1999) Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 18: 4891-8 PubMed GONUTS page

[PMID:12176997-2] Basso AD et al. (2002) Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 277: 39858-66 PubMed GONUTS page

[PMID:12434148-3] Yang J et al. (2002) Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol 9: 940-4 PubMed GONUTS page

[PMID:16417406-4] Weiner OD et al. (2006) Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol 4: e38 PubMed GONUTS page

[PMID:17030088-5] Nechamen CA et al. (2007) APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. Mol Cell Endocrinol 260-262: 93-9 PubMed GONUTS page

[PMID:17535800-6] Lyons TR et al. (2007) Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. J Biol Chem 282: 21987-97 PubMed GONUTS page

[PMID:17577629-7] Gao H et al. (2007) Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression. Mol Cell Biochem 305: 35-44 PubMed GONUTS page

[PMID:19713527-8] Yang WL et al. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325: 1134-8 PubMed GONUTS page

[PMID:20059950-9] 10.0 ^10.1 Suizu F et al. (2009) The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell 17: 800-10 PubMed GONUTS page

[PMID:16814735-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Bouzakri K et al. (2006) siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab 4: 89-96 PubMed GONUTS page

[PMID:17332325-11] Cheng GZ et al. (2007) Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res 67: 1979-87 PubMed GONUTS page

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HUMAN:AKT2

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