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HUMAN:AK1C3

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Contents

Species (Taxon ID) Homo sapiens (Human). (taxon:9606)
Gene Name(s) AKR1C3 ( synonyms: DDH1, HSD17B5, KIAA0119, PGFS )
Protein Name(s)
  • Aldo-keto reductase family 1 member C3
  • 17-beta-hydroxysteroid dehydrogenase type 5
  • 17-beta-HSD 5
  • 3-alpha-HSD type II, brain
  • 3-alpha-hydroxysteroid dehydrogenase type 2
  • 3-alpha-HSD type 2
  • Chlordecone reductase homolog HAKRb
  • Dihydrodiol dehydrogenase 3
  • DD-3
  • DD3
  • Dihydrodiol dehydrogenase type I
  • HA1753
  • Indanol dehydrogenase
  • Prostaglandin F synthase
  • PGFS
  • Testosterone 17-beta-dehydrogenase 5
  • Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
External Links
UniProt Identifier AK1C3_HUMAN
UniProt Accessions P42330, A8K2V0, Q5T2L1, Q96DJ1, Q96KI8, Q99530, Q9UCX1, Q9UII3, Q9UKL9,
EMBL S68288, L43839, L43831, L43832, L43833, L43834, L43835, L43836, L43837, L43838, AB018580, AB028065, AF149416, AB032157, D17793, BT007286, AK290365, AL391427, BC001479, BC019230,
PIR B57407, I73674,
RefSeq NP_003730.4,
PDB 1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2FGB,
IntAct P42330,
Ensembl ENST00000380554,
Pfam PF00248,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001395

P

GO:0005622

intracellular

PMID:11256614[1]

IDA: Inferred from Direct Assay

C

GO:0016491

oxidoreductase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

GO:0055114

oxidation-reduction process

PMID:9792917[2]

TAS: Traceable Author Statement

P

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

GO:0004033

aldo-keto reductase activity

PMID:9792917[2]

TAS: Traceable Author Statement

F

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

GO:0016491

oxidoreductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018170

F

GO:0047017

prostaglandin-F synthase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.1.1.188

F

GO:0047115

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.3.1.20

F

GO:0050327

testosterone 17-beta-dehydrogenase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.1.1.63

F

GO:0016491

oxidoreductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020471

F

GO:0047045

testosterone 17-beta-dehydrogenase (NADP+) activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.1.1.64

F

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018170

P

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020471

P

GO:0047026

androsterone dehydrogenase (A-specific) activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.1.1.213

F

GO:0016491

oxidoreductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001395

F

GO:0055114

oxidation-reduction process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

GO:0047718

indanol dehydrogenase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.1.1.112

F

GO:0004033

aldo-keto reductase activity

PMID:9792917[2]

IEP: Inferred from Expression Pattern

F

See Table 2.

complete

GO:0006693

prostaglandin metabolic process

PMID:9792917[2]

TAS: Traceable Author Statement

P

GO:0004033

aldo-keto reductase (NADP) activity

PMID:9792917[2]

TAS: Traceable Author Statement

F

GO:0005622

intracellular

PMID:11256614[1]

IDA: Inferred from Direct Assay

C

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

GO:0006693

prostaglandin metabolic process

PMID:9792917[2]

TAS: Traceable Author Statement

P

GO:0016491

oxidoreductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018170

F

GO:0016491

oxidoreductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020471

F

GO:0016491

oxidoreductase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

GO:0047017

prostaglandin-F synthase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.1.1.188

F

GO:0047026

androsterone dehydrogenase (A-specific) activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.1.1.213

F

GO:0047045

testosterone 17-beta-dehydrogenase (NADP+) activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.1.1.64

F

GO:0047115

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.3.1.20

F

GO:0047718

indanol dehydrogenase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.1.1.112

F

GO:0050327

testosterone 17-beta-dehydrogenase (NAD+) activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:1.1.1.63

F

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018170

P

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020471

P

GO:0055114

oxidation-reduction process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

GO:0055114

oxidation-reduction process

PMID:9792917[2]

TAS: Traceable Author Statement

P


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Simpson JC et al. (2000) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep 1: 287-92 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Matsuura K et al. (1998) Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity. J Biochem 124: 940-6 PubMed GONUTS page
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