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HUMAN:ACSF3

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Contents

Species (Taxon ID) Homo sapiens (Human). ([1])
Gene Name(s) ACSF3
Protein Name(s) Acyl-CoA synthetase family member 3, mitochondrial
External Links
EMBL AK075499
AK290963
AC009113
AC135782
CH471184
BC028399
BC072391
IPI IPI00166395
IPI00450347
RefSeq NP_001120686.1
NP_777577.2
UniGene Hs.461727
ProteinModelPortal Q4G176
SMR Q4G176
PhosphoSite Q4G176
PRIDE Q4G176
Ensembl ENST00000317447
ENST00000406948
GeneID 197322
KEGG hsa:197322
CTD 197322
GeneCards GC16P074859
H-InvDB HIX0013347
HGNC HGNC:27288
HPA HPA008322
HPA008323
neXtProt NX_Q4G176
PharmGKB PA162375375
GeneTree ENSGT00530000062988
HOGENOM HBG547964
HOVERGEN HBG100430
InParanoid Q4G176
OrthoDB EOG4NCMCN
ArrayExpress Q4G176
Bgee Q4G176
CleanEx HS_ACSF3
Genevestigator Q4G176
GO GO:0005739
GO:0016878
GO:0005524
GO:0006631
InterPro IPR020845
IPR000873
Pfam PF00501
PROSITE PS00455

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

GO:0003824

catalytic activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000873

F

GO:0005524

ATP binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

GO:0005739

mitochondrion

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0496

C

GO:0005739

mitochondrion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000015160

C

GO:0005739

mitochondrion

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0173

C

GO:0006629

lipid metabolic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0443

P

GO:0006631

fatty acid metabolic process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0276

P

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000873

P

incorrect (CACAO)

GO:0005515

protein binding

PMID:0000004[1]

IPI: Inferred from Physical Interaction

SP_KW:KW-0436


F

Sample annotation. testing date

complete

GO:0005836

fatty-acyl-CoA synthase complex

PMID:17762044[2]

IDA: Inferred from Direct Assay

C

Table 4

complete

GO:0090409

malonyl-CoA synthetase activity

PMID:21846720[3]

IDA: Inferred from Direct Assay

F

Fig. 1D shows the enzyme converting malonate to malonyl-CoA in the presence of ATP and CoA.

complete

GO:0016878

acid-thiol ligase activity

PMID:17762044[2]

IDA: Inferred from Direct Assay

F


Notes

References

See Help:References for how to manage references in GONUTS.

  1. Wiesmann UN et al. (1975) Effect of chloroquine on cultured fibroblasts: release of lysosomal hydrolases and inhibition of their uptake. Biochem Biophys Res Commun 66: 1338-43 PubMed GONUTS page
  2. 2.0 2.1 Watkins PA et al. (2007) Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. J Lipid Res 48: 2736-50 PubMed GONUTS page
  3. Witkowski A et al. (2011) Mammalian ACSF3 protein is a malonyl-CoA synthetase that supplies the chain extender units for mitochondrial fatty acid synthesis. J Biol Chem 286: 33729-36 PubMed GONUTS page
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