HUMAN:ACES

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ACHE
Protein Name(s)	Acetylcholinesterase AChE
External Links
UniProt	P22303
EMBL	M55040 S71129 AF334270 AK291321 AK223443 AY750146 AC011895 AC011895 CH236956 CH236956 CH471091 CH471091 CH471091 BC036813 BC105060 BC105062 BC143469 AF312032
IPI	IPI00220026 IPI00552259 IPI00844209 IPI00913969
PIR	A39256
RefSeq	NP_000656.1 NP_056646.1
UniGene	Hs.154495
PDB	1B41 1F8U 1PUV 1PUW 1VZJ 2CLJ 2X8B 3LII
PDBsum	1B41 1F8U 1PUV 1PUW 1VZJ 2CLJ 2X8B 3LII
ProteinModelPortal	P22303
SMR	P22303
DIP	DIP-1119N
IntAct	P22303
MINT	MINT-149019
STRING	P22303
MEROPS	S09.979
PhosphoSite	P22303
DMDM	113037
SWISS-2DPAGE	P22303
PRIDE	P22303
Ensembl	ENST00000241069 ENST00000302913 ENST00000411582 ENST00000412389 ENST00000428317
GeneID	43
KEGG	hsa:43
UCSC	uc003uxd.1
CTD	43
GeneCards	GC07M100487
HGNC	HGNC:108
HPA	HPA019704
MIM	100740 112100
neXtProt	NX_P22303
PharmGKB	PA20
eggNOG	prNOG15352
GeneTree	ENSGT00600000084311
HOVERGEN	HBG008839
OrthoDB	EOG46WZ86
Reactome	REACT_13685
DrugBank	DB01122 DB00572 DB00122 DB01245 DB00944 DB00843 DB01010 DB01364 DB00674 DB00483 DB00677 DB01400 DB00981 DB00545 DB00989 DB00382 DB01199
NextBio	173
ArrayExpress	P22303
Bgee	P22303
Genevestigator	P22303
GermOnline	ENSG00000087085
GO	GO:0031225 GO:0030424 GO:0005605 GO:0030054 GO:0009986 GO:0030425 GO:0005788 GO:0005615 GO:0005794 GO:0031594 GO:0005634 GO:0048471 GO:0005886 GO:0045211 GO:0042734 GO:0043083 GO:0042166 GO:0003990 GO:0001540 GO:0004091 GO:0005518 GO:0043237 GO:0042803 GO:0017171 GO:0001507 GO:0042982 GO:0007155 GO:0008283 GO:0019695 GO:0006260 GO:0007517 GO:0032223 GO:0042136 GO:0002076 GO:0050714 GO:0050770 GO:0048814 GO:0009611 GO:0007416
InterPro	IPR014788 IPR002018 IPR019826 IPR019819 IPR000997
KO	K01049
Pfam	PF08674 PF00135
PRINTS	PR00878
ProDom	PD415333
PROSITE	PS00122 PS00941

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001507	acetylcholine catabolic process in synaptic cleft	PMID:1517212^[1]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0001540	beta-amyloid binding	PMID:11283752^[2]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0001919	regulation of receptor recycling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	P	Seeded From UniProt
	GO:0002076	osteoblast development	PMID:15454088^[3]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0003990	acetylcholinesterase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.1.1.7	F	Seeded From UniProt
	GO:0003990	acetylcholinesterase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	F	Seeded From UniProt
	GO:0003990	acetylcholinesterase activity	PMID:1517212^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0003990	acetylcholinesterase activity	PMID:1517212^[1]	IMP: Inferred from Mutant Phenotype		F	Seeded From UniProt
	GO:0004091	carboxylesterase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014788	F	Seeded From UniProt
	GO:0004091	carboxylesterase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0719	F	Seeded From UniProt
	GO:0004091	carboxylesterase activity	GO_REF:0000033		PANTHER:PTHR11559_AN0	F	Seeded From UniProt
	GO:0004104	cholinesterase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000997	F	Seeded From UniProt
	GO:0004104	cholinesterase activity	PMID:1517212^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005515	protein binding	PMID:10800960^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O60888	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15526038^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y215	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18194455^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P06733	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18194455^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P63244	F	Seeded From UniProt
	GO:0005518	collagen binding	PMID:12524166^[7]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C	Seeded From UniProt
	GO:0005576	extracellular region	PMID:11283752^[2]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	PMID:1517212^[1]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005605	basal lamina	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	C	Seeded From UniProt
	GO:0005605	basal lamina	PMID:16289501^[8]	NAS: Non-traceable Author Statement		C	Seeded From UniProt
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	C	Seeded From UniProt
	GO:0005615	extracellular space	GO_REF:0000033		PANTHER:PTHR11559_AN47	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C	Seeded From UniProt
	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000033		PANTHER:PTHR11559_AN47	C	Seeded From UniProt
	GO:0005794	Golgi apparatus	PMID:15454088^[3]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_14816	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0006260	DNA replication	PMID:11283752^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006581	acetylcholine catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	P	Seeded From UniProt
	GO:0006581	acetylcholine catabolic process	PMID:1517212^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0007155	cell adhesion	PMID:11283752^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007155	cell adhesion	PMID:15454088^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0007268	synaptic transmission	Reactome:REACT_13477	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007268	synaptic transmission	Reactome:REACT_13685	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007271	synaptic transmission, cholinergic	GO_REF:0000033		PANTHER:PTHR11559_AN1	P	Seeded From UniProt
	GO:0007399	nervous system development	PMID:11283752^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007416	synapse assembly	GO_REF:0000033		PANTHER:PTHR11559_AN72	P	Seeded From UniProt
	GO:0007416	synapse assembly	PMID:11283752^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007517	muscle organ development	PMID:11283752^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008283	cell proliferation	PMID:11283752^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0009611	response to wounding	PMID:11283752^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	C	Seeded From UniProt
	GO:0009986	cell surface	GO_REF:0000033		PANTHER:PTHR11559_AN72	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014788	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016020	membrane	PMID:16262697^[9]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded From UniProt
	GO:0016787	hydrolase activity	PMID:1517212^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0017171	serine hydrolase activity	PMID:3954986^[10]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0019695	choline metabolic process	GO_REF:0000033		PANTHER:PTHR11559_AN1	P	Seeded From UniProt
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C	Seeded From UniProt
	GO:0030424	axon	GO_REF:0000033		PANTHER:PTHR11559_AN72	C	Seeded From UniProt
	GO:0030425	dendrite	GO_REF:0000033		PANTHER:PTHR11559_AN72	C	Seeded From UniProt
	GO:0031225	anchored to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0336	C	Seeded From UniProt
	GO:0031594	neuromuscular junction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	C	Seeded From UniProt
	GO:0031594	neuromuscular junction	GO_REF:0000033		PANTHER:PTHR11559_AN72	C	Seeded From UniProt
	GO:0031623	receptor internalization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	P	Seeded From UniProt
	GO:0032223	negative regulation of synaptic transmission, cholinergic	PMID:1517212^[1]	IC: Inferred by Curator	GO:0006581	P	Seeded From UniProt
	GO:0042135	neurotransmitter catabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0531	P	Seeded From UniProt
	GO:0042136	neurotransmitter biosynthetic process	Reactome:REACT_13583	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0042166	acetylcholine binding	PMID:1517212^[1]	NAS: Non-traceable Author Statement		F	Seeded From UniProt
	GO:0042166	acetylcholine binding	PMID:8349597^[11]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0042734	presynaptic membrane	GO_REF:0000033		PANTHER:PTHR11559_AN72	C	Seeded From UniProt
	GO:0042803	protein homodimerization activity	PMID:12524166^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P22303	F	Seeded From UniProt
	GO:0042803	protein homodimerization activity	PMID:1517212^[1]	NAS: Non-traceable Author Statement		F	Seeded From UniProt
	GO:0042982	amyloid precursor protein metabolic process	PMID:12769797^[12]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0043083	synaptic cleft	PMID:1517212^[1]	NAS: Non-traceable Author Statement		C	Seeded From UniProt
	GO:0043236	laminin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	F	Seeded From UniProt
	GO:0043236	laminin binding	PMID:12524166^[7]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0043621	protein self-association	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	F	Seeded From UniProt
	GO:0045202	synapse	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0770	C	Seeded From UniProt
	GO:0045202	synapse	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	C	Seeded From UniProt
	GO:0045202	synapse	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0258	C	Seeded From UniProt
	GO:0045202	synapse	PMID:8460160^[13]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0045211	postsynaptic membrane	GO_REF:0000033		PANTHER:PTHR11559_AN72	C	Seeded From UniProt
	GO:0045212	neurotransmitter receptor biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	P	Seeded From UniProt
	GO:0048471	perinuclear region of cytoplasm	PMID:14766237^[14]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0048814	regulation of dendrite morphogenesis	GO_REF:0000033		PANTHER:PTHR11559_AN72	P	Seeded From UniProt
	GO:0050714	positive regulation of protein secretion	PMID:11283752^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0050770	regulation of axonogenesis	GO_REF:0000033		PANTHER:PTHR11559_AN72	P	Seeded From UniProt
	GO:0051262	protein tetramerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	P	Seeded From UniProt
	GO:0060041	retina development in camera-type eye	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024099	P	Seeded From UniProt
	GO:0050435	beta-amyloid metabolic process	PMID:17140265^[15]	IDA: Inferred from Direct Assay		P	THC is an inhibitor of AChE which leads to a decrease of beta-amyloid accumulation.	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Shafferman A et al. (1992) Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. J Biol Chem 267: 17640-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Soreq H & Seidman S (2001) Acetylcholinesterase--new roles for an old actor. Nat Rev Neurosci 2: 294-302 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Inkson CA et al. (2004) Characterization of acetylcholinesterase expression and secretion during osteoblast differentiation. Bone 35: 819-27 PubMed GONUTS page
↑ Navaratnam DS et al. (2000) Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization. J Neurochem 74: 2146-53 PubMed GONUTS page
↑ Dvir H et al. (2004) The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. EMBO J 23: 4394-405 PubMed GONUTS page
↑ ^6.0 ^6.1 Mor I et al. (2008) Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility. J Cell Mol Med 12: 479-95 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Johnson G & Moore SW (2003) Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site. Neurosci Lett 337: 37-40 PubMed GONUTS page
↑ Guerra M et al. (2005) Acetylcholinesterase and molecular interactions at the neuromuscular junction. Chem Biol Interact 157-158: 57-61 PubMed GONUTS page
↑ Carvalho FA et al. (2005) Biochemical characterization of human umbilical vein endothelial cell membrane bound acetylcholinesterase. FEBS J 272: 5584-94 PubMed GONUTS page
↑ Bazelyansky M et al. (1986) Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase. Biochemistry 25: 125-30 PubMed GONUTS page
↑ Ordentlich A et al. (1993) Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket. J Biol Chem 268: 17083-95 PubMed GONUTS page
↑ Pakaski M & Kasa P (2003) Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein. Curr Drug Targets CNS Neurol Disord 2: 163-71 PubMed GONUTS page
↑ Ben Aziz-Aloya R et al. (1993) Expression of a human acetylcholinesterase promoter-reporter construct in developing neuromuscular junctions of Xenopus embryos. Proc Natl Acad Sci U S A 90: 2471-5 PubMed GONUTS page
↑ Schallreuter KU et al. (2004) Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun 315: 502-8 PubMed GONUTS page
↑ Eubanks LM et al. (2006) A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol Pharm 3: 773-7 PubMed GONUTS page

[PMID:1517212-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Shafferman A et al. (1992) Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. J Biol Chem 267: 17640-8 PubMed GONUTS page

[PMID:11283752-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Soreq H & Seidman S (2001) Acetylcholinesterase--new roles for an old actor. Nat Rev Neurosci 2: 294-302 PubMed GONUTS page

[PMID:15454088-2] 3.0 ^3.1 ^3.2 Inkson CA et al. (2004) Characterization of acetylcholinesterase expression and secretion during osteoblast differentiation. Bone 35: 819-27 PubMed GONUTS page

[PMID:10800960-3] Navaratnam DS et al. (2000) Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization. J Neurochem 74: 2146-53 PubMed GONUTS page

[PMID:15526038-4] Dvir H et al. (2004) The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. EMBO J 23: 4394-405 PubMed GONUTS page

[PMID:18194455-5] 6.0 ^6.1 Mor I et al. (2008) Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility. J Cell Mol Med 12: 479-95 PubMed GONUTS page

[PMID:12524166-6] 7.0 ^7.1 ^7.2 Johnson G & Moore SW (2003) Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site. Neurosci Lett 337: 37-40 PubMed GONUTS page

[PMID:16289501-7] Guerra M et al. (2005) Acetylcholinesterase and molecular interactions at the neuromuscular junction. Chem Biol Interact 157-158: 57-61 PubMed GONUTS page

[PMID:16262697-8] Carvalho FA et al. (2005) Biochemical characterization of human umbilical vein endothelial cell membrane bound acetylcholinesterase. FEBS J 272: 5584-94 PubMed GONUTS page

[PMID:3954986-9] Bazelyansky M et al. (1986) Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase. Biochemistry 25: 125-30 PubMed GONUTS page

[PMID:8349597-10] Ordentlich A et al. (1993) Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket. J Biol Chem 268: 17083-95 PubMed GONUTS page

[PMID:12769797-11] Pakaski M & Kasa P (2003) Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein. Curr Drug Targets CNS Neurol Disord 2: 163-71 PubMed GONUTS page

[PMID:8460160-12] Ben Aziz-Aloya R et al. (1993) Expression of a human acetylcholinesterase promoter-reporter construct in developing neuromuscular junctions of Xenopus embryos. Proc Natl Acad Sci U S A 90: 2471-5 PubMed GONUTS page

[PMID:14766237-13] Schallreuter KU et al. (2004) Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun 315: 502-8 PubMed GONUTS page

[PMID:17140265-14] Eubanks LM et al. (2006) A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol Pharm 3: 773-7 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

HUMAN:ACES

Contents

Annotations

Notes

References

a

b

c

d

d cont.

e

g

h

l

m

n

o

p

p cont.

r

s

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox