HUMAN:ABL1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	ABL1 ( synonyms: ABL, JTK7 )
Protein Name(s)	Tyrosine-protein kinase ABL1 Abelson murine leukemia viral oncogene homolog 1 Proto-oncogene c-Abl p150
External Links
UniProt Identifier	ABL1_HUMAN
UniProt Accessions	P00519, A3KFJ3, Q13869, Q13870, Q16133, Q17R61, Q45F09,
EMBL	M14752, X16416, U07563, U07563, U07561, DQ145721, AL359092, AL161733, AL161733, AL161733, AL359092, CH471090, BC117451, S69223,
PIR	S08519,
RefSeq	NP_005148.2, NP_009297.2,
PDB	1AB2, 1ABL, 1AWO, 1BBZ, 1JU5, 1OPL, 1ZZP, 2ABL, 2E2B, 2F4J, 2FO0, 2G1T, 2G2F, 2G2H, 2G2I, 2GQG, 2HIW, 2HYY, 2HZ0, 2HZ4, 2HZI, 2O88, 2V7A, 3CS9, 3EG0, 3EG1, 3EG2, 3EG3, 3EGU, 3K2M, 3QRI, 3QRJ, 3QRK,
IntAct	P00519,
Ensembl	ENST00000318560,
Pfam	PF08919, PF07714, PF00017, PF00018,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0051019	mitogen-activated protein kinase binding	PMID 11121037	IPI: Inferred from Physical Interaction	UniProtKB:Q13177	F	Figure 1 and Figures 2 b and c	complete
	GO:0005829	cytosol		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0031965	nuclear membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005730	nucleolus		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0048471	perinuclear region of cytoplasm		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005524	ATP binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0003677	DNA binding		NAS: Non-traceable Author Statement		F	Source: UniProtKB
	GO:0000287	magnesium ion binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0030145	manganese ion binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0004715	non-membrane spanning protein tyrosine kina...		IEA: Inferred from Electronic Annotation		F	Source: EC
	GO:0070064	proline-rich region binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0008022	protein C-terminus binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0017124	SH3 domain binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0030036	actin cytoskeleton organization		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0007155	cell adhesion		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0008630	DNA damage response, signal transduction re...		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0006298	mismatch repair		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0018108	peptidyl-tyrosine phosphorylation		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0051353	positive regulation of oxidoreductase activity		IDA: Inferred from Direct Assay		P	Source: BHF-UCL
	GO:0000115	regulation of transcription involved in S p...		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0005856	cytoskeleton		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0071901	negative regulation of protein serine/threonine kinase activity	PMID 11121037	IDA: Inferred from Direct Assay		P	Figure 4 c and d	complete
	GO:0004713	protein tyrosine kinase activity	PMID 11121037	IDA: Inferred from Direct Assay		F	Figure 5 b lane 3 compared to lane 1	complete
	GO:0000115	regulation of transcription involved in S phase of mitotic cell cycle	PMID:8242749^[1]	TAS: Traceable Author Statement		P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000287	magnesium ion binding	PMID:9144171^[2]	IDA: Inferred from Direct Assay		F
	GO:0003677	DNA binding	PMID:8242749^[1]	NAS: Non-traceable Author Statement		F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020635	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0829	F
	GO:0004713	protein tyrosine kinase activity	PMID:10391249^[3]	TAS: Traceable Author Statement		F
	GO:0004713	protein tyrosine kinase activity	PMID:11121037^[4]	IDA: Inferred from Direct Assay		F
	GO:0004713	protein tyrosine kinase activity	PMID:17888034^[5]	IDA: Inferred from Direct Assay		F
	GO:0004713	protein tyrosine kinase activity	PMID:7590236^[6]	IDA: Inferred from Direct Assay		F
	GO:0004713	protein tyrosine kinase activity	PMID:9144171^[2]	IDA: Inferred from Direct Assay		F
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015015	F
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.10.2	F
	GO:0005515	protein binding	PMID:11374898^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BX66	F
	GO:0005515	protein binding	PMID:11374898^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BX66	F
	GO:0005515	protein binding	PMID:11375976^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P54274-2	F
	GO:0005515	protein binding	PMID:11375976^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P54274-2	F
	GO:0005515	protein binding	PMID:11375976^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q13315	F
	GO:0005515	protein binding	PMID:12893824^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P07203	F
	GO:0005515	protein binding	PMID:15696159^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P31947	F
	GO:0005515	protein binding	PMID:15696159^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P63104	F
	GO:0005515	protein binding	PMID:17129785^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q63767	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O00254	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O14490	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O14513	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O15056	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O15085	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O15117	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O15255	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O15320	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O43281	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O43390	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O43493	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O43708	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O43900	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O43918	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O60244	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O60493	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O60721	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O75326	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O75751	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O76039	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O76081	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O94856	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O95157	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:O95886	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P02765	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P06241	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P06865	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P08047	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P12018	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P12931	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P13671	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P15586	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P16333	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P19174	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P20774	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P20810	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P21333	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P23760	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P26992	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P27986	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P28340	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P29074	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P30260	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P31273	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P32239	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P34820	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P42167	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P42566	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P43699	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P46013	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P46108	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P49450	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P49916	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P50570	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P50851	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P51587	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P52803	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P62993	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P78329	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P78345	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P78357	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P98161	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P98164	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q05193	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q07890	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q08209	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q12947	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q12979	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q13023	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q13087	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q13415	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q13905	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q14008	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q14315	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q14767	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q14999	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q15027	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q15036	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q15427	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q7Z408	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q86SG6	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q86UR5	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IZD9	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NFP9	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TAS1	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TB24	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q8WX92	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q92664	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q92874	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q92918	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q92988	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q96AC6	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q96GP6	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q96NS5	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q96RL7	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q99259	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q99572	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BQ89	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BWW9	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BXM0	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BYB0	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BZM3	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9C0E4	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H0X9	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H1R2	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H2X0	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H5I1	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HCM9	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9HCQ7	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NQ76	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NQC3	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NRJ4	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NUR3	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NYQ7	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NZQ3	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NZV5	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9P1A6	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UBS5	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UHL9	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UIF9	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UJT2	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UJV9	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UK85	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UL51	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9ULD4	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9ULH1	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UM47	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UMN6	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UMY4	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UN72	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UN86	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UQ16	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y2H0	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y2J2	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y3Q4	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y3S1	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y5K6	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y5X2	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y5Y3	F
	GO:0005515	protein binding	PMID:17474147^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y697	F
	GO:0005515	protein binding	PMID:17888034^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O95684	F
	GO:0005515	protein binding	PMID:7590236^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NYB9	F
	GO:0005515	protein binding	PMID:9010225^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q8CBW3	F
	GO:0005515	protein binding	PMID:9144171^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q13671	F
	GO:0005515	protein binding	PMID:9593709^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IZP0	F
	GO:0005515	protein binding	PMID:9632734^[15]	IPI: Inferred from Physical Interaction	UniProtKB:P78524	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015015	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005524	ATP binding	PMID:9144171^[2]	IDA: Inferred from Direct Assay		F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:17888034^[5]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18029348^[16]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:8242749^[1]	NAS: Non-traceable Author Statement		C
	GO:0005730	nucleolus	PMID:12944467^[17]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005829	cytosol	Reactome:REACT_19227	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_19396	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_21288	TAS: Traceable Author Statement		C
	GO:0005856	cytoskeleton	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0206	C
	GO:0005856	cytoskeleton	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0090	C
	GO:0006298	mismatch repair	PMID:10391249^[3]	TAS: Traceable Author Statement		P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:8242749^[1]	TAS: Traceable Author Statement		P
	GO:0006464	protein modification process	PMID:8242749^[1]	NAS: Non-traceable Author Statement		P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015015	P
	GO:0006975	DNA damage induced protein phosphorylation	PMID:18280240^[18]	IDA: Inferred from Direct Assay		P
	GO:0007155	cell adhesion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0130	P
	GO:0007411	axon guidance	Reactome:REACT_18266	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0008022	protein C-terminus binding	PMID:11971963^[19]	IPI: Inferred from Physical Interaction	UniProtKB:Q99638	F
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	PMID:10391249^[3]	TAS: Traceable Author Statement		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0017124	SH3 domain binding	PMID:7590236^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NYB9	F
	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:11121037^[4]	IDA: Inferred from Direct Assay		P
	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:7590236^[6]	IDA: Inferred from Direct Assay		P
	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:9144171^[2]	IDA: Inferred from Direct Assay		P
	GO:0030036	actin cytoskeleton organization	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P00520	P
	GO:0030145	manganese ion binding	PMID:9144171^[2]	IDA: Inferred from Direct Assay		F
	GO:0031965	nuclear membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0182	C
	GO:0042692	muscle cell differentiation	Reactome:REACT_21303	TAS: Traceable Author Statement		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048471	perinuclear region of cytoplasm	PMID:17888034^[5]	IDA: Inferred from Direct Assay		C
	GO:0051019	mitogen-activated protein kinase binding	PMID:11121037^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q13177	F
	GO:0051149	positive regulation of muscle cell differentiation	Reactome:REACT_21402	TAS: Traceable Author Statement		P
	GO:0051353	positive regulation of oxidoreductase activity	PMID:12893824^[9]	IDA: Inferred from Direct Assay		P
	GO:0070064	proline-rich region binding	PMID:7590236^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NYB9	F
	GO:0071901	negative regulation of protein serine/threonine kinase activity	PMID:11121037^[4]	IDA: Inferred from Direct Assay		P
NOT	GO:0005730	nucleolus	PMID:18029348^[16]	IDA: Inferred from Direct Assay		C
	GO:0043065	positive regulation of apoptosis	PMID:9037071^[20]	IDA: Inferred from Direct Assay		P	Figures 1,3,4: Activation of c-Abl protein tyrosine kinase regulates DNA damage-induced apoptosis; an overexpression shows a significant difference in number of dead cells.	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Welch PJ & Wang JY (1993) A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 75: 779-90 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Han L et al. (1997) Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc Natl Acad Sci U S A 94: 4954-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Gong JG et al. (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Roig J et al. (2000) Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc Natl Acad Sci U S A 97: 14346-51 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Mano Y et al. (2007) Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. Cancer Sci 98: 1902-13 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Dai Z & Pendergast AM (1995) Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Genes Dev 9: 2569-82 PubMed GONUTS page
↑ ^7.0 ^7.1 Lin WH et al. (2001) Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B. Genomics 74: 12-20 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Kishi S et al. (2001) Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem 276: 29282-91 PubMed GONUTS page
↑ ^9.0 ^9.1 Cao C et al. (2003) Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J Biol Chem 278: 39609-14 PubMed GONUTS page
↑ ^10.0 ^10.1 Yoshida K et al. (2005) JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol 7: 278-85 PubMed GONUTS page
↑ Sawada Y et al. (2006) Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell 127: 1015-26 PubMed GONUTS page
↑ ^12.000 ^12.001 ^12.002 ^12.003 ^12.004 ^12.005 ^12.006 ^12.007 ^12.008 ^12.009 ^12.010 ^12.011 ^12.012 ^12.013 ^12.014 ^12.015 ^12.016 ^12.017 ^12.018 ^12.019 ^12.020 ^12.021 ^12.022 ^12.023 ^12.024 ^12.025 ^12.026 ^12.027 ^12.028 ^12.029 ^12.030 ^12.031 ^12.032 ^12.033 ^12.034 ^12.035 ^12.036 ^12.037 ^12.038 ^12.039 ^12.040 ^12.041 ^12.042 ^12.043 ^12.044 ^12.045 ^12.046 ^12.047 ^12.048 ^12.049 ^12.050 ^12.051 ^12.052 ^12.053 ^12.054 ^12.055 ^12.056 ^12.057 ^12.058 ^12.059 ^12.060 ^12.061 ^12.062 ^12.063 ^12.064 ^12.065 ^12.066 ^12.067 ^12.068 ^12.069 ^12.070 ^12.071 ^12.072 ^12.073 ^12.074 ^12.075 ^12.076 ^12.077 ^12.078 ^12.079 ^12.080 ^12.081 ^12.082 ^12.083 ^12.084 ^12.085 ^12.086 ^12.087 ^12.088 ^12.089 ^12.090 ^12.091 ^12.092 ^12.093 ^12.094 ^12.095 ^12.096 ^12.097 ^12.098 ^12.099 ^12.100 ^12.101 ^12.102 ^12.103 ^12.104 ^12.105 ^12.106 ^12.107 ^12.108 ^12.109 ^12.110 ^12.111 ^12.112 ^12.113 ^12.114 ^12.115 ^12.116 ^12.117 ^12.118 ^12.119 ^12.120 ^12.121 ^12.122 ^12.123 ^12.124 ^12.125 ^12.126 ^12.127 ^12.128 ^12.129 ^12.130 ^12.131 ^12.132 ^12.133 ^12.134 ^12.135 ^12.136 ^12.137 ^12.138 ^12.139 Wu C et al. (2007) Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Proteomics 7: 1775-85 PubMed GONUTS page
↑ Biesova Z et al. (1997) Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth. Oncogene 14: 233-41 PubMed GONUTS page
↑ Ziemnicka-Kotula D et al. (1998) Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton. J Biol Chem 273: 13681-92 PubMed GONUTS page
↑ Majidi M et al. (1998) Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5. J Biol Chem 273: 16608-14 PubMed GONUTS page
↑ ^16.0 ^16.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ Cheng WH et al. (2003) Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol Cell Biol 23: 6385-95 PubMed GONUTS page
↑ Levy D et al. (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell 29: 350-61 PubMed GONUTS page
↑ Yoshida K et al. (2002) c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Mol Cell Biol 22: 3292-300 PubMed GONUTS page
↑ Yuan ZM et al. (1997) Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc Natl Acad Sci U S A 94: 1437-40 PubMed GONUTS page

[PMID:8242749-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Welch PJ & Wang JY (1993) A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 75: 779-90 PubMed GONUTS page

[PMID:9144171-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Han L et al. (1997) Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc Natl Acad Sci U S A 94: 4954-9 PubMed GONUTS page

[PMID:10391249-2] 3.0 ^3.1 ^3.2 Gong JG et al. (1999) The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 399: 806-9 PubMed GONUTS page

[PMID:11121037-3] 4.0 ^4.1 ^4.2 ^4.3 Roig J et al. (2000) Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. Proc Natl Acad Sci U S A 97: 14346-51 PubMed GONUTS page

[PMID:17888034-4] 5.0 ^5.1 ^5.2 ^5.3 Mano Y et al. (2007) Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. Cancer Sci 98: 1902-13 PubMed GONUTS page

[PMID:7590236-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Dai Z & Pendergast AM (1995) Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. Genes Dev 9: 2569-82 PubMed GONUTS page

[PMID:11374898-6] 7.0 ^7.1 Lin WH et al. (2001) Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B. Genomics 74: 12-20 PubMed GONUTS page

[PMID:11375976-7] 8.0 ^8.1 ^8.2 Kishi S et al. (2001) Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem 276: 29282-91 PubMed GONUTS page

[PMID:12893824-8] 9.0 ^9.1 Cao C et al. (2003) Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. J Biol Chem 278: 39609-14 PubMed GONUTS page

[PMID:15696159-9] 10.0 ^10.1 Yoshida K et al. (2005) JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol 7: 278-85 PubMed GONUTS page

[PMID:17129785-10] Sawada Y et al. (2006) Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Cell 127: 1015-26 PubMed GONUTS page

[PMID:17474147-11] 12.000 ^12.001 ^12.002 ^12.003 ^12.004 ^12.005 ^12.006 ^12.007 ^12.008 ^12.009 ^12.010 ^12.011 ^12.012 ^12.013 ^12.014 ^12.015 ^12.016 ^12.017 ^12.018 ^12.019 ^12.020 ^12.021 ^12.022 ^12.023 ^12.024 ^12.025 ^12.026 ^12.027 ^12.028 ^12.029 ^12.030 ^12.031 ^12.032 ^12.033 ^12.034 ^12.035 ^12.036 ^12.037 ^12.038 ^12.039 ^12.040 ^12.041 ^12.042 ^12.043 ^12.044 ^12.045 ^12.046 ^12.047 ^12.048 ^12.049 ^12.050 ^12.051 ^12.052 ^12.053 ^12.054 ^12.055 ^12.056 ^12.057 ^12.058 ^12.059 ^12.060 ^12.061 ^12.062 ^12.063 ^12.064 ^12.065 ^12.066 ^12.067 ^12.068 ^12.069 ^12.070 ^12.071 ^12.072 ^12.073 ^12.074 ^12.075 ^12.076 ^12.077 ^12.078 ^12.079 ^12.080 ^12.081 ^12.082 ^12.083 ^12.084 ^12.085 ^12.086 ^12.087 ^12.088 ^12.089 ^12.090 ^12.091 ^12.092 ^12.093 ^12.094 ^12.095 ^12.096 ^12.097 ^12.098 ^12.099 ^12.100 ^12.101 ^12.102 ^12.103 ^12.104 ^12.105 ^12.106 ^12.107 ^12.108 ^12.109 ^12.110 ^12.111 ^12.112 ^12.113 ^12.114 ^12.115 ^12.116 ^12.117 ^12.118 ^12.119 ^12.120 ^12.121 ^12.122 ^12.123 ^12.124 ^12.125 ^12.126 ^12.127 ^12.128 ^12.129 ^12.130 ^12.131 ^12.132 ^12.133 ^12.134 ^12.135 ^12.136 ^12.137 ^12.138 ^12.139 Wu C et al. (2007) Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Proteomics 7: 1775-85 PubMed GONUTS page

[PMID:9010225-12] Biesova Z et al. (1997) Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth. Oncogene 14: 233-41 PubMed GONUTS page

[PMID:9593709-13] Ziemnicka-Kotula D et al. (1998) Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton. J Biol Chem 273: 13681-92 PubMed GONUTS page

[PMID:9632734-14] Majidi M et al. (1998) Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5. J Biol Chem 273: 16608-14 PubMed GONUTS page

[PMID:18029348-15] 16.0 ^16.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:12944467-16] Cheng WH et al. (2003) Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. Mol Cell Biol 23: 6385-95 PubMed GONUTS page

[PMID:18280240-17] Levy D et al. (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell 29: 350-61 PubMed GONUTS page

[PMID:11971963-18] Yoshida K et al. (2002) c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Mol Cell Biol 22: 3292-300 PubMed GONUTS page

[PMID:9037071-19] Yuan ZM et al. (1997) Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc Natl Acad Sci U S A 94: 1437-40 PubMed GONUTS page

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HUMAN:ABL1

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