HUMAN:ABEC1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	APOBEC1
Protein Name(s)	C->U-editing enzyme APOBEC-1 Apolipoprotein B mRNA-editing enzyme 1 HEPR
External Links
UniProt Identifier	ABEC1_HUMAN
UniProt Accessions	P41238, Q9UE64, Q9UM71,
EMBL	L25877, L26234, U72891, AB009426, U78720,
PIR	I59323,
RefSeq	NP_001635.2,
Ensembl	ENST00000229304,
Pfam	PF05240, PF08210,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007904	F
	GO:0004126	cytidine deaminase activity	PMID:7736571^[1]	TAS: Traceable Author Statement		F
	GO:0051592	response to calcium ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0016554	cytidine to uridine editing	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0010332	response to gamma radiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0017091	AU-rich element binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	F
	GO:0016556	mRNA modification	Reactome:REACT_1757	TAS: Traceable Author Statement		P
	GO:0005654	nucleoplasm	Reactome:REACT_869	TAS: Traceable Author Statement		C
	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013158	F
	GO:0042953	lipoprotein transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0006970	response to osmotic stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0045471	response to ethanol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0010043	response to zinc ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0006396	RNA processing	PMID:7736571^[1]	TAS: Traceable Author Statement		P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007904	F
	GO:0005654	nucleoplasm	Reactome:REACT_99	TAS: Traceable Author Statement		C
	GO:0016787	hydrolase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016192	F
	GO:0016554	cytidine to uridine editing	Reactome:REACT_167	TAS: Traceable Author Statement		P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016192	F
	GO:0008270	zinc ion binding	PMID:7736571^[1]	TAS: Traceable Author Statement		F
	GO:0004126	cytidine deaminase activity	Reactome:REACT_869	TAS: Traceable Author Statement		F
	GO:0016556	mRNA modification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0042158	lipoprotein biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0009972	cytidine deamination	PMID:7736571^[1]	TAS: Traceable Author Statement		P
	GO:0003723	RNA binding	PMID:7736571^[1]	TAS: Traceable Author Statement		F
	GO:0051607	defense response to virus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0048255	mRNA stabilization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0009972	cytidine deamination	Reactome:REACT_869	TAS: Traceable Author Statement		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0004126	cytidine deaminase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	F
	GO:0009972	cytidine deamination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0006629	lipid metabolic process	PMID:8078915^[2]	TAS: Traceable Author Statement		P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0042157	lipoprotein metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0016554	cytidine to uridine editing	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013158	F
	GO:0032869	cellular response to insulin stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0016556	mRNA modification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0006397	mRNA processing	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0507	P
	GO:0003723	RNA binding	PMID:7736571^[1]	TAS: Traceable Author Statement		F
	GO:0004126	cytidine deaminase activity	PMID:7736571^[1]	TAS: Traceable Author Statement		F
	GO:0005654	nucleoplasm	Reactome:REACT_869	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_99	TAS: Traceable Author Statement		C
	GO:0006396	RNA processing	PMID:7736571^[1]	TAS: Traceable Author Statement		P
	GO:0006397	mRNA processing	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0507	P
	GO:0006629	lipid metabolic process	PMID:8078915^[2]	TAS: Traceable Author Statement		P
	GO:0006970	response to osmotic stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007904	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013158	F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016192	F
	GO:0008270	zinc ion binding	PMID:7736571^[1]	TAS: Traceable Author Statement		F
	GO:0009972	cytidine deamination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0009972	cytidine deamination	PMID:7736571^[1]	TAS: Traceable Author Statement		P
	GO:0010043	response to zinc ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0010332	response to gamma radiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0016554	cytidine to uridine editing	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0016554	cytidine to uridine editing	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0016554	cytidine to uridine editing	Reactome:REACT_167	TAS: Traceable Author Statement		P
	GO:0016556	mRNA modification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0016556	mRNA modification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0016556	mRNA modification	Reactome:REACT_1757	TAS: Traceable Author Statement		P
	GO:0016787	hydrolase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016192	F
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007904	F
	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013158	F
	GO:0017091	AU-rich element binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	F
	GO:0032869	cellular response to insulin stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0042157	lipoprotein metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0042158	lipoprotein biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0042953	lipoprotein transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0045471	response to ethanol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048255	mRNA stabilization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000108205	P
	GO:0051592	response to calcium ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0051607	defense response to virus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020735	P
	GO:0080111	DNA demethylation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P51908	P
	GO:0090310	negative regulation of methylation-dependent chromatin silencing	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P51908	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Navaratnam N et al. (1995) Evolutionary origins of apoB mRNA editing: catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site. Cell 81: 187-95 PubMed GONUTS page
↑ ^2.0 ^2.1 Lau PP et al. (1994) Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. Proc Natl Acad Sci U S A 91: 8522-6 PubMed GONUTS page

[PMID:7736571-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Navaratnam N et al. (1995) Evolutionary origins of apoB mRNA editing: catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site. Cell 81: 187-95 PubMed GONUTS page

[PMID:8078915-1] 2.0 ^2.1 Lau PP et al. (1994) Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. Proc Natl Acad Sci U S A 91: 8522-6 PubMed GONUTS page

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HUMAN:ABEC1

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