HUMAN:5HT1A

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	HTR1A ( synonyms: ADRB2RL1, ADRBRL1 )
Protein Name(s)	5-hydroxytryptamine receptor 1A 5-HT-1A 5-HT1A G-21 Serotonin receptor 1A
External Links
UniProt Identifier	5HT1A_HUMAN
UniProt Accessions	P08908, Q6LAE7,
EMBL	M28269, X13556, X57829, M83181, AB041403, AF498978, BC069159, Z11168,
PIR	I38209,
RefSeq	NP_000515.2,
Ensembl	ENST00000323865,
Pfam	PF00001,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005887	integral to plasma membrane		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0004993	serotonin receptor activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0007610	behavior		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0008284	positive regulation of cell proliferation		TAS: Traceable Author Statement		P	Source: ProtInc
NOT	GO:0007616	long-term memory	PMID:12562581^[1]	EXP: Inferred from Experiment		P	Figure 1 Discussion: "It appears evident that the activity of postsynaptic 5-HT1A receptors in the hippocampus has an inhibitory influence on human explicit memory function." (Paragraph 3)	complete
	GO:0004871	signal transducer activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0807	F
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0297	F
	GO:0004993	serotonin receptor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013618	F
	GO:0004993	serotonin receptor activity	PMID:9736659^[2]	TAS: Traceable Author Statement		F
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	Reactome:REACT_15538	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_16978	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_22239	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_22289	TAS: Traceable Author Statement		C
	GO:0005887	integral to plasma membrane	PMID:3138543^[3]	TAS: Traceable Author Statement		C
	GO:0007165	signal transduction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0807	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000276	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000610	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002231	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0297	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	PMID:1330092^[4]	TAS: Traceable Author Statement		P
	GO:0007198	inhibition of adenylate cyclase activity by serotonin receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013618	P
	GO:0007210	serotonin receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013618	P
	GO:0007210	serotonin receptor signaling pathway	PMID:9736659^[2]	TAS: Traceable Author Statement		P
	GO:0007610	behavior	PMID:9736659^[2]	TAS: Traceable Author Statement		P
	GO:0008144	drug binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013618	F
	GO:0008284	positive regulation of cell proliferation	PMID:1330092^[4]	TAS: Traceable Author Statement		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013618	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000276	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000610	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002231	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0043025	neuronal cell body	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013618	C
	GO:0043203	axon hillock	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013618	C
	GO:0051378	serotonin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013618	F
	GO:0060259	regulation of feeding behavior	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000013618	P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yasuno F et al. (2003) Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory. Am J Psychiatry 160: 334-40 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Stockmeier CA et al. (1998) Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J Neurosci 18: 7394-401 PubMed GONUTS page
↑ Fargin A et al. (1988) The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature 335: 358-60 PubMed GONUTS page
↑ ^4.0 ^4.1 Varrault A et al. (1992) Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis. Mol Biol Cell 3: 961-9 PubMed GONUTS page

[PMID:12562581-0] Yasuno F et al. (2003) Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory. Am J Psychiatry 160: 334-40 PubMed GONUTS page

[PMID:9736659-1] 2.0 ^2.1 ^2.2 Stockmeier CA et al. (1998) Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J Neurosci 18: 7394-401 PubMed GONUTS page

[PMID:3138543-2] Fargin A et al. (1988) The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature 335: 358-60 PubMed GONUTS page

[PMID:1330092-3] 4.0 ^4.1 Varrault A et al. (1992) Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis. Mol Biol Cell 3: 961-9 PubMed GONUTS page

[1]

[2]

[3]

[4]

HUMAN:5HT1A

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

l

m

n

p

p cont.

r

s

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox