HPV31:VE2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012677	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000427	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001866	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009021	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000427	F
	GO:0006260	DNA replication	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0235	P
	GO:0006275	regulation of DNA replication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000427	P
	GO:0006275	regulation of DNA replication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001866	P
	GO:0006275	regulation of DNA replication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009021	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:19211738^[1] GO_REF:0000002	IEP: Inferred from Expression Pattern		P	The E2 protein of human papillomavirus (HPV) binds to specific sites in the viral genome to regulate its transcription, replication, and maintenance in infected cells.Using this assay, the E2 proteins from a low-risk (HPV11) and a high-risk (HPV31) human papillomavirus (HPV) type were found to have short half-lives of 60 min in C33A cervical carcinoma cells and to be ubiquitinated and degraded by the proteasome. Analysis of mutant proteins showed that the instability of E2 is independent of its DNA-binding and transcriptional activities but is encoded within its transactivation domain, the region that binds to the cellular chromatin factor bromodomain-containing protein 4 (Brd4) to regulate viral gene transcription. Figure 1. Figure 3.	complete
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001866	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0016032	viral reproduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001866	P
	GO:0042025	host cell nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000427	C
	GO:0042025	host cell nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1048	C
	GO:0042025	host cell nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0414	C
	GO:0000166	nucleotide binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012677	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000427	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001866	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009021	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000427	F
	GO:0006260	DNA replication	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0235	P
	GO:0006275	regulation of DNA replication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000427	P
	GO:0006275	regulation of DNA replication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001866	P
	GO:0006275	regulation of DNA replication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009021	P
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000427	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001866	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0016032	viral reproduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001866	P
	GO:0042025	host cell nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000427	C
	GO:0042025	host cell nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1048	C
	GO:0042025	host cell nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0414	C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gagnon D et al. (2009) Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4. J Virol 83: 4127-39 PubMed GONUTS page

[PMID:19211738-0] Gagnon D et al. (2009) Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4. J Virol 83: 4127-39 PubMed GONUTS page

[1]

Species (Taxon ID)	Human papillomavirus type 31. (taxon:10585)
Gene Name(s)	E2
Protein Name(s)	Regulatory protein E2
External Links
UniProt Identifier	VE2_HPV31
UniProt Accessions	P17383,
EMBL	J04353,
PIR	D32444,
PDB	1A7G, 1DHM,
Pfam	PF00511, PF00508,

HPV31:VE2

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