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FB:twi

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) twi ( synonyms: CG2956, DTwist, EC9, TWI, Tw, Twi, Twist, bHLHb17, dip5 )
Protein Name(s) twist,
External Links
FB FBgn0003900

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001710

mesodermal cell fate commitment

FB:FBrf0075064

TAS: Traceable Author Statement

P

From FB

GO:0001710

mesodermal cell fate commitment

FB:FBrf0138533
PMID:11486054[1]

TAS: Traceable Author Statement

P

From FB

GO:0001710

mesodermal cell fate commitment

FB:FBrf0138569
PMID:11688563[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0003677

DNA binding

FB:FBrf0123517

NAS: Non-traceable Author Statement

F

From FB

GO:0003677

DNA binding

FB:FBrf0138569
PMID:11688563[2]

IDA: Inferred from Direct Assay

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q8WVJ9

F

From FB

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0100308
PMID:9362473[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0005634

nucleus

FB:FBrf0047934
PMID:3416836[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q8WVJ9

C

From FB

GO:0005634

nucleus

FB:FBrf0123517

NAS: Non-traceable Author Statement

C

From FB

GO:0005737

cytoplasm

FB:FBrf0211995
PMID:20802461[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0006357

regulation of transcription from RNA polymerase II promoter

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q8WVJ9

P

From FB

GO:0007369

gastrulation

FB:FBrf0110176
PMID:10369659[6]

NAS: Non-traceable Author Statement

P

From FB

GO:0007370

ventral furrow formation

FB:FBrf0075064

TAS: Traceable Author Statement

P

From FB

GO:0007375

anterior midgut invagination

FB:FBrf0075064

NAS: Non-traceable Author Statement

P

From FB

GO:0007435

salivary gland morphogenesis

FB:FBrf0190174
PMID:16171793[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007443

Malpighian tubule morphogenesis

FB:FBrf0111391
PMID:10502111[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007498

mesoderm development

FB:FBrf0123517

NAS: Non-traceable Author Statement

P

From FB

GO:0007498

mesoderm development

FB:FBrf0130167
PMID:11128983[9]

TAS: Traceable Author Statement

P

From FB

GO:0007498

mesoderm development

FB:FBrf0138533
PMID:11486054[1]

IEP: Inferred from Expression Pattern

P

From FB

GO:0007498

mesoderm development

FB:FBrf0144780
PMID:11839291[10]

NAS: Non-traceable Author Statement

P

From FB

GO:0007498

mesoderm development

FB:FBrf0151249
PMID:12027431[11]

TAS: Traceable Author Statement

P

From FB

GO:0007499

ectoderm and mesoderm interaction

FB:FBrf0147042
PMID:11959838[12]

NAS: Non-traceable Author Statement

P

From FB

GO:0007500

mesodermal cell fate determination

FB:FBrf0108595
PMID:10218153[13]

TAS: Traceable Author Statement

P

From FB

GO:0007501

mesodermal cell fate specification

FB:FBrf0141281
PMID:11700289[14]

TAS: Traceable Author Statement

P

From FB

GO:0007501

mesodermal cell fate specification

FB:FBrf0148941
PMID:12027434[15]

TAS: Traceable Author Statement

P

From FB

GO:0007507

heart development

FB:FBrf0151249
PMID:12027431[11]

TAS: Traceable Author Statement

P

From FB

GO:0009950

dorsal/ventral axis specification

FB:FBrf0141281
PMID:11700289[14]

TAS: Traceable Author Statement

P

From FB

GO:0010004

gastrulation involving germ band extension

FB:FBrf0179905
PMID:15380237[16]

TAS: Traceable Author Statement

P

From FB

GO:0010629

negative regulation of gene expression

FB:FBrf0193889
PMID:16780828[17]

IDA: Inferred from Direct Assay

P

From FB

GO:0016202

regulation of striated muscle tissue development

FB:FBrf0138569
PMID:11688563[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0031032

actomyosin structure organization

FB:FBrf0210158
PMID:20194639[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042803

protein homodimerization activity

FB:FBrf0138569
PMID:11688563[2]

IPI: Inferred from Physical Interaction

UniProtKB:P10627

F

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0100308
PMID:9362473[3]

IDA: Inferred from Direct Assay

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0110176
PMID:10369659[6]

NAS: Non-traceable Author Statement

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0111461
PMID:10490660[19]

IDA: Inferred from Direct Assay

P

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0138569
PMID:11688563[2]

IPI: Inferred from Physical Interaction

UniProtKB:P11420

F

From FB

GO:0048747

muscle fiber development

FB:FBrf0190139
PMID:16325168[20]

IMP: Inferred from Mutant Phenotype

P

From FB

contributes_to

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0155780
PMID:12459265[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0260632

F

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Furlong EE et al. (2001) Patterns of gene expression during Drosophila mesoderm development. Science 293: 1629-33 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Castanon I et al. (2001) Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development. Development 128: 3145-59 PubMed GONUTS page
  3. 3.0 3.1 Yin Z et al. (1997) Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development 124: 4971-82 PubMed GONUTS page
  4. Thisse B et al. (1988) Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos. EMBO J 7: 2175-83 PubMed GONUTS page
  5. Tipping M et al. (2010) β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development. EMBO J 29: 3222-35 PubMed GONUTS page
  6. 6.0 6.1 Leptin M (1999) Gastrulation in Drosophila: the logic and the cellular mechanisms. EMBO J 18: 3187-92 PubMed GONUTS page
  7. Vining MS et al. (2005) Organ positioning in Drosophila requires complex tissue-tissue interactions. Dev Biol 287: 19-34 PubMed GONUTS page
  8. Jack J & Myette G (1999) Mutations that alter the morphology of the malpighian tubules in Drosophila. Dev Genes Evol 209: 546-54 PubMed GONUTS page
  9. Wilson R & Leptin M (2000) Fibroblast growth factor receptor-dependent morphogenesis of the Drosophila mesoderm. Philos Trans R Soc Lond B Biol Sci 355: 891-5 PubMed GONUTS page
  10. Taylor MV (2002) Drosophila development: novel signal elicits visceral response. Curr Biol 12: R102-4 PubMed GONUTS page
  11. 11.0 11.1 Cripps RM & Olson EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 246: 14-28 PubMed GONUTS page
  12. Stainier DY (2002) A glimpse into the molecular entrails of endoderm formation. Genes Dev 16: 893-907 PubMed GONUTS page
  13. Bate M et al. (1999) Development of larval body wall muscles. Int Rev Neurobiol 43: 25-44 PubMed GONUTS page
  14. 14.0 14.1 Lall S & Patel NH (2001) Conservation and divergence in molecular mechanisms of axis formation. Annu Rev Genet 35: 407-37 PubMed GONUTS page
  15. Stathopoulos A & Levine M (2002) Dorsal gradient networks in the Drosophila embryo. Dev Biol 246: 57-67 PubMed GONUTS page
  16. Stathopoulos A & Levine M (2004) Whole-genome analysis of Drosophila gastrulation. Curr Opin Genet Dev 14: 477-84 PubMed GONUTS page
  17. Anderson J et al. (2006) Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. Dev Biol 297: 536-49 PubMed GONUTS page
  18. Martin AC et al. (2010) Integration of contractile forces during tissue invagination. J Cell Biol 188: 735-49 PubMed GONUTS page
  19. Postigo AA et al. (1999) zfh-1, the Drosophila homologue of ZEB, is a transcriptional repressor that regulates somatic myogenesis. Mol Cell Biol 19: 7255-63 PubMed GONUTS page
  20. Lovato TL et al. (2005) Transcription of Myocyte enhancer factor-2 in adult Drosophila myoblasts is induced by the steroid hormone ecdysone. Dev Biol 288: 612-21 PubMed GONUTS page
  21. Bhaskar V & Courey AJ (2002) The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist. Gene 299: 173-84 PubMed GONUTS page
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