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FB:ttk

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) ttk ( synonyms: 0037/17, 0250/25, 0438/31, 0702/07, 1049/07, 1119/04, 1184/16, 1209/05, 1209/10, 1260/10, 1281/04, 1325/15, 1372/08, 1396/14, 1418/06, 3540, 5125, 5311, CG11558, CG1856, E(yan)100D, Enhancer of yan at 100D, FTZ-F2, TTK, TTK69, TTK88, TTKA, Tramtrack, Tramtrack69, Tramtrack88, Tramtrak, Ttk, Ttk69, Ttk88, Ttk88 repressor, anon-EST:Liang-2.9, clone 2.9, ftz-f2, ftzf2/ttk, l(3)02667, l(3)j2A1, l(3)j7B8, osn, oss, oversensitive, ovs, schmal, tramtrack-69, tramtrack69, tramtrak, ttk/FTZ-F2, ttk69, ttkp69, twk )
Protein Name(s) tramtrack,
External Links
FB FBgn0003870

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0123660

NAS: Non-traceable Author Statement

P

From FB

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0124021

NAS: Non-traceable Author Statement

P

From FB

GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

FB:FBrf0055940
PMID:1372245[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

FB:FBrf0109169
PMID:10381570[2]

IDA: Inferred from Direct Assay

F

From FB

GO:0001078

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription

FB:FBrf0180423
PMID:15306652[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0001709

cell fate determination

FB:FBrf0174511
PMID:15018932[4]

TAS: Traceable Author Statement

P

From FB

GO:0001964

startle response

FB:FBrf0205756
PMID:18713854[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0002121

inter-male aggressive behavior

FB:FBrf0208496
PMID:19519879[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0003682

chromatin binding

FB:FBrf0180423
PMID:15306652[3]

IDA: Inferred from Direct Assay

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0105495

NAS: Non-traceable Author Statement

F

From FB

GO:0005515

protein binding

FB:FBrf0152286
PMID:12384587[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q08605

F

From FB

GO:0005515

protein binding

FB:FBrf0180423
PMID:15306652[3]

IPI: Inferred from Physical Interaction

FB:FBgn0261573

F

From FB

GO:0005634

nucleus

FB:FBrf0055940
PMID:1372245[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0105495

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0123660

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0124021

NAS: Non-traceable Author Statement

C

From FB

GO:0005634

nucleus

FB:FBrf0180423
PMID:15306652[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0005700

polytene chromosome

FB:FBrf0141519
PMID:11743021[8]

IDA: Inferred from Direct Assay

C

From FB

GO:0005700

polytene chromosome

FB:FBrf0212010
PMID:20733004[9]

IDA: Inferred from Direct Assay

C

From FB

GO:0006357

regulation of transcription from RNA polymerase II promoter

FB:FBrf0105495

NAS: Non-traceable Author Statement

P

From FB

GO:0007422

peripheral nervous system development

FB:FBrf0083410
PMID:8060613[10]

TAS: Traceable Author Statement

P

From FB

GO:0007426

tracheal outgrowth, open tracheal system

FB:FBrf0201143
PMID:17881489[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008270

zinc ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR007087
InterPro:IPR015880

F

From FB

GO:0008360

regulation of cell shape

FB:FBrf0209360
PMID:19934014[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016476

regulation of embryonic cell shape

FB:FBrf0201143
PMID:17881489[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0017053

transcriptional repressor complex

FB:FBrf0180423
PMID:15306652[3]

IPI: Inferred from Physical Interaction

FB:FBgn0261573

C

From FB

GO:0030707

ovarian follicle cell development

FB:FBrf0189756
PMID:16542414[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0031987

locomotion involved in locomotory behavior

FB:FBrf0205756
PMID:18713854[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035001

dorsal trunk growth, open tracheal system

FB:FBrf0201143
PMID:17881489[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035147

branch fusion, open tracheal system

FB:FBrf0201143
PMID:17881489[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035151

regulation of tube size, open tracheal system

FB:FBrf0201143
PMID:17881489[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0040003

chitin-based cuticle development

FB:FBrf0201143
PMID:17881489[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042675

compound eye cone cell differentiation

FB:FBrf0209609
PMID:20003234[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042803

protein homodimerization activity

FB:FBrf0152286
PMID:12384587[7]

IPI: Inferred from Physical Interaction

UniProtKB:P17789

F

From FB

GO:0045467

R7 cell development

FB:FBrf0129916
PMID:10929403[15]

TAS: Traceable Author Statement

P

From FB

GO:0045467

R7 cell development

FB:FBrf0209609
PMID:20003234[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045892

negative regulation of transcription, DNA-dependent

FB:FBrf0180423
PMID:15306652[3]

IDA: Inferred from Direct Assay

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0109169
PMID:10381570[2]

IDA: Inferred from Direct Assay

P

From FB

GO:0046843

dorsal appendage formation

FB:FBrf0155483
PMID:12490195[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046843

dorsal appendage formation

FB:FBrf0209360
PMID:19934014[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048053

R1/R6 development

FB:FBrf0209609
PMID:20003234[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048666

neuron development

FB:FBrf0190556
PMID:16547170[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048750

compound eye corneal lens morphogenesis

FB:FBrf0209609
PMID:20003234[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0190556
PMID:16547170[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048854

brain morphogenesis

FB:FBrf0205756
PMID:18713854[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0060446

branching involved in open tracheal system development

FB:FBrf0201143
PMID:17881489[11]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Read D & Manley JL (1992) Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities. EMBO J 11: 1035-44 PubMed GONUTS page
  2. 2.0 2.1 Yu Y et al. (1999) A double interaction screen identifies positive and negative ftz gene regulators and ftz-interacting proteins. Mech Dev 83: 95-105 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Dallman JE et al. (2004) A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation. J Neurosci 24: 7186-93 PubMed GONUTS page
  4. Bardin AJ et al. (2004) Asymmetric localization and function of cell-fate determinants: a fly's view. Curr Opin Neurobiol 14: 6-14 PubMed GONUTS page
  5. 5.0 5.1 5.2 Yamamoto A et al. (2008) Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Proc Natl Acad Sci U S A 105: 12393-8 PubMed GONUTS page
  6. Edwards AC et al. (2009) Mutations in many genes affect aggressive behavior in Drosophila melanogaster. BMC Biol 7: 29 PubMed GONUTS page
  7. 7.0 7.1 Pagans S et al. (2002) The Drosophila transcription factor tramtrack (TTK) interacts with Trithorax-like (GAGA) and represses GAGA-mediated activation. Nucleic Acids Res 30: 4406-13 PubMed GONUTS page
  8. Murawsky CM et al. (2001) Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex. EMBO Rep 2: 1089-94 PubMed GONUTS page
  9. Reddy BA et al. (2010) Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol Cell Biol 30: 5234-44 PubMed GONUTS page
  10. Salzberg A et al. (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13: 269-87 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 11.6 Araújo SJ et al. (2007) Tramtrack regulates different morphogenetic events during Drosophila tracheal development. Development 134: 3665-76 PubMed GONUTS page
  12. 12.0 12.1 Boyle MJ & Berg CA (2009) Control in time and space: Tramtrack69 cooperates with Notch and Ecdysone to repress ectopic fate and shape changes during Drosophila egg chamber maturation. Development 136: 4187-97 PubMed GONUTS page
  13. Jordan KC et al. (2006) Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. BMC Dev Biol 6: 16 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 Siddall NA et al. (2009) Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc. BMC Dev Biol 9: 64 PubMed GONUTS page
  15. Kumar JP & Moses K (2000) Cell fate specification in the Drosophila retina. Results Probl Cell Differ 31: 93-114 PubMed GONUTS page
  16. French RL et al. (2003) The Drosophila female sterile mutation twin peaks is a novel allele of tramtrack and reveals a requirement for Ttk69 in epithelial morphogenesis. Dev Biol 253: 18-35 PubMed GONUTS page
  17. 17.0 17.1 Parrish JZ et al. (2006) Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev 20: 820-35 PubMed GONUTS page
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