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FB:th
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | th ( synonyms: 0736/01, 1065/03, CG12284, D-IAP1, D-iap1, DIAP, DIAP I, DIAP-1, DIAP1, DIAPI, Diap, Diap-1, Diap-1/Th, Diap1, Drosophila IAP1, Drosophila Inhibitor of Apoptosis, Drosophila Inhibitor of Apoptosis 1, Drosophila Inhibitor of Apoptosis Protein, Drosophila Inhibitor of Apoptosis Protein 1, Drosophila Inhibitor of Apoptosis Protein-1, Drosophila Inhibitor of apoptosis protein 1, Drosophila inhibitor of apoptosis, Drosophila inhibitor of apoptosis 1, Drosophila inhibitor of apoptosis protein, Drosophila inhibitor of apoptosis protein 1, Drosophila inhibitor-of-apoptosis protein 1, Drosophila thread/inhibitor of apoptosis protein-1, E(rpr)3-1, IAP, IAP1, Iap1, Inhibitor of Apoptosis 1, Inhibitor of Apoptosis Protein 1, Inhibitor of apoptosis 1, Inhibitors of Apoptosis protein, S048915, Thread, dIAP, dIAP-1, dIAP1, dIap1, degradation of inhibitors of apoptosis, diap, diap 1, diap-1, diap1, diap1/thread, inhibitor of apoptosis, inhibitor of apoptosis protein 1, inhibitor of apoptosis-1, l(3)72CDe, l(3)72Dc, l(3)S030605, l(3)S030605b, l(3)S106503, l(3)j5C8, lethal (3) 72CDe, rosophila inhibitor of apoptosis protein ) | |
| Protein Name(s) | thread, | |
| External Links | ||
| FB | FBgn0260635 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004842 |
ubiquitin-protein ligase activity |
FB:FBrf0156082 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0194448 |
IPI: Inferred from Physical Interaction |
FB:FBgn0086657 |
F |
From FB |
||
| GO:0005622 |
intracellular |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
C |
From FB |
|||
| GO:0006513 |
protein monoubiquitination |
FB:FBrf0156082 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0125392 |
IPI: Inferred from Physical Interaction |
FB:FBgn0003997 |
P |
From FB |
||
| GO:0006915 |
apoptotic process |
FB:FBrf0125392 |
IPI: Inferred from Physical Interaction |
FB:FBgn0011706 |
P |
From FB |
||
| GO:0006915 |
apoptotic process |
FB:FBrf0149068 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0173268 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0104543 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0111320 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0124290 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0125392 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003997 |
P |
From FB |
||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0125392 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0011706 |
P |
From FB |
||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0132215 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0134786 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0147184 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0156082 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0161621 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006916 |
anti-apoptosis |
FB:FBrf0167429 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007275 |
multicellular organismal development |
FB:FBrf0132215 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007289 |
spermatid nucleus differentiation |
FB:FBrf0167989 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0179220 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010333 |
P |
From FB |
||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0179220 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0201428 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007423 |
sensory organ development |
FB:FBrf0190361 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008270 |
zinc ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0008354 |
germ cell migration |
FB:FBrf0160454 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008407 |
chaeta morphogenesis |
FB:FBrf0209002 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009987 |
cellular process |
FB:FBrf0175143 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0019788 |
NEDD8 ligase activity |
FB:FBrf0212528 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0019899 |
enzyme binding |
FB:FBrf0212528 |
IPI: Inferred from Physical Interaction |
FB:FBgn0035853 |
F |
From FB |
||
| GO:0031398 |
positive regulation of protein ubiquitination |
FB:FBrf0206305 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0042787 |
protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
FB:FBrf0160832 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0042787 |
protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
FB:FBrf0167429 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0043066 |
negative regulation of apoptotic process |
FB:FBrf0085197 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043066 |
negative regulation of apoptotic process |
FB:FBrf0085197 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0043066 |
negative regulation of apoptotic process |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0043066 |
negative regulation of apoptotic process |
FB:FBrf0111320 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0043066 |
negative regulation of apoptotic process |
FB:FBrf0156082 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0134503 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0149068 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0167429 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0192581 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0019972 |
P |
From FB |
||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0192581 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0024252 |
P |
From FB |
||
| GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0192581 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0026404 |
P |
From FB |
||
| GO:0045035 |
sensory organ precursor cell division |
FB:FBrf0209002 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0086657 |
P |
From FB |
||
| GO:0046673 |
negative regulation of compound eye retinal cell programmed cell death |
FB:FBrf0192581 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048800 |
antennal morphogenesis |
FB:FBrf0179745 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Ditzel M & Meier P (2002) IAP degradation: decisive blow or altruistic sacrifice? Trends Cell Biol 12: 449-52 PubMed GONUTS page
- ↑ Kuranaga E et al. (2006) Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell 126: 583-96 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Goyal L et al. (2000) Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J 19: 589-97 PubMed GONUTS page
- ↑ 4.0 4.1 Richardson H & Kumar S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J Immunol Methods 265: 21-38 PubMed GONUTS page
- ↑ Lawen A (2003) Apoptosis-an introduction. Bioessays 25: 888-96 PubMed GONUTS page
- ↑ Hawkins CJ et al. (1998) Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells. Cell Death Differ 5: 569-76 PubMed GONUTS page
- ↑ 7.0 7.1 Abrams JM (1999) An emerging blueprint for apoptosis in Drosophila. Trends Cell Biol 9: 435-40 PubMed GONUTS page
- ↑ 8.0 8.1 Tittel JN & Steller H (2000) A comparison of programmed cell death between species. Genome Biol 1: REVIEWS0003 PubMed GONUTS page
- ↑ Meier P et al. (2000) Apoptosis in development. Nature 407: 796-801 PubMed GONUTS page
- ↑ Gorski S & Marra M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol Genomics 9: 59-69 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Bergmann A et al. (2003) Regulators of IAP function: coming to grips with the grim reaper. Curr Opin Cell Biol 15: 717-24 PubMed GONUTS page
- ↑ Huh JR et al. (2004) Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol 2: E15 PubMed GONUTS page
- ↑ 13.0 13.1 Geisbrecht ER & Montell DJ (2004) A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration. Cell 118: 111-25 PubMed GONUTS page
- ↑ Mathieu J et al. (2007) A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics 176: 1579-90 PubMed GONUTS page
- ↑ Kanuka H et al. (2005) Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J 24: 3793-806 PubMed GONUTS page
- ↑ Coffman CR (2003) Cell migration and programmed cell death of Drosophila germ cells. Ann N Y Acad Sci 995: 117-26 PubMed GONUTS page
- ↑ 17.0 17.1 Koto A et al. (2009) Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development. J Cell Biol 187: 219-31 PubMed GONUTS page
- ↑ Boutros M et al. (2004) Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303: 832-5 PubMed GONUTS page
- ↑ 19.0 19.1 Broemer M et al. (2010) Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases. Mol Cell 40: 810-22 PubMed GONUTS page
- ↑ Ditzel M et al. (2008) Inactivation of effector caspases through nondegradative polyubiquitylation. Mol Cell 32: 540-53 PubMed GONUTS page
- ↑ Ou CY et al. (2003) Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. Trends Genet 19: 382-9 PubMed GONUTS page
- ↑ Kumar S & Doumanis J (2000) The fly caspases. Cell Death Differ 7: 1039-44 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 23.3 Leulier F et al. (2006) Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ 13: 1663-74 PubMed GONUTS page
- ↑ Cullen K & McCall K (2004) Role of programmed cell death in patterning the Drosophila antennal arista. Dev Biol 275: 82-92 PubMed GONUTS page
