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FB:syt

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Drosophila melanogaster (fruit fly)

syt:synaptotagmin
Synonyms:CG3139, D. Syt I, DSYT, DSYT2, Dsyt2, SYT, SYT I, SYT1, Synaptotagmin, Synaptotagmin 1, Synaptotagmin I, SynaptotagminI, Syt, Syt I, Syt-1, Syt1, SytI, dSYT, dsyt1, dsytI, l(2)23AB1, l(2)23Ba, l(2)k05909, synaptotagmin 1, synaptotagmin I, syt I, syt-1, syt1, sytI
syt on FlyBase

GO terms

GO:0005215_!_transporter_activity (F) IEA with/from InterPro:IPR001565 [1]
GO:0005509_!_calcium_ion_binding (F) ISS [2]
GO:0005515_!_protein_binding (F) IPI with/from FB:FBgn0016975 [3]
GO:0005515_!_protein_binding (F) IPI with/from FB:FBgn0016976 [3]
GO:0005544_!_calcium-dependent_phospholipid_binding (F) TAS [4]
GO:0006887_!_exocytosis (P) NAS [5]
GO:0007269_!_neurotransmitter_secretion (P) IMP [6]
GO:0007269_!_neurotransmitter_secretion (P) IMP [2]
GO:0007269_!_neurotransmitter_secretion (P) NAS [4]
GO:0007317_!_regulation_of_pole_plasm_oskar_mRNA_localization (P) IMP [7]
GO:0008021_!_synaptic_vesicle (C) NAS [8]
GO:0008021_!_synaptic_vesicle (C) ISS [9]
GO:0008021_!_synaptic_vesicle (C) IDA [10]
GO:0008345_!_larval_locomotory_behavior (P) IMP [2]
GO:0016020_!_membrane (C) NAS [8]
GO:0016020_!_membrane (C) IEA with/from InterPro:IPR001565 [1]
GO:0016079_!_synaptic_vesicle_exocytosis (P) ISS [9]
GO:0016192_!_vesicle-mediated_transport (P) IMP [11]
GO:0016192_!_vesicle-mediated_transport (P) TAS [12]
GO:0016192_!_vesicle-mediated_transport (P) TAS [4]
GO:0016192_!_vesicle-mediated_transport (P) TAS [7]
GO:0030285_!_integral_to_synaptic_vesicle_membrane (C) NAS [2]
GO:0031594_!_neuromuscular_junction (C) IDA [13]
GO:0048488_!_synaptic_vesicle_endocytosis (P) IMP [14]
GO:0048489_!_synaptic_vesicle_transport (P) NAS [8]
GO:0048791_!_calcium_ion-dependent_exocytosis_of_neurotransmitter (P) IMP [15]
GO:0050803_!_regulation_of_synapse_structure_and_activity (P) IMP [16]

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Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 FB:FBrf0174215 FBrf0174215
  2. 2.0 2.1 2.2 2.3 Littleton JT et al. (1994) Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants. Proc Natl Acad Sci U S A 91: 10888-92 PubMed GONUTS page
  3. 3.0 3.1 Phillips AM et al. (2000) The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin. J Neurosci 20: 8254-61 PubMed GONUTS page
  4. 4.0 4.1 4.2 Littleton JT et al. (1999) Mechanisms of neurotransmitter release. Int Rev Neurobiol 43: 139-61 PubMed GONUTS page
  5. FB:FBrf0078115 FBrf0078115
  6. Littleton JT et al. (1993) Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca(2+)-activated neurotransmitter release. Cell 74: 1125-34 PubMed GONUTS page
  7. 7.0 7.1 Ruden DM et al. (2000) Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber. Dev Biol 218: 314-25 PubMed GONUTS page
  8. 8.0 8.1 8.2 FB:FBrf0123757 FBrf0123757
  9. 9.0 9.1 Littleton JT (2000) A genomic analysis of membrane trafficking and neurotransmitter release in Drosophila. J Cell Biol 150: F77-82 PubMed GONUTS page
  10. Narayanan R et al. (2005) An internal GAP domain negatively regulates presynaptic dynamin in vivo: a two-step model for dynamin function. J Cell Biol 169: 117-26 PubMed GONUTS page
  11. Broadie K et al. (1994) Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission. Proc Natl Acad Sci U S A 91: 10727-31 PubMed GONUTS page
  12. Stimson DT & Ramaswami M (1999) Vesicle recycling at the Drosophila neuromuscular junction. Int Rev Neurobiol 43: 163-89 PubMed GONUTS page
  13. Loewen CA et al. (2001) Drosophila synaptotagmin I null mutants survive to early adulthood. Genesis 31: 30-6 PubMed GONUTS page
  14. Poskanzer KE et al. (2003) Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo. Nature 426: 559-63 PubMed GONUTS page
  15. Saraswati S et al. (2007) Characterization of the role of the Synaptotagmin family as calcium sensors in facilitation and asynchronous neurotransmitter release. Proc Natl Acad Sci U S A 104: 14122-7 PubMed GONUTS page
  16. Dickman DK et al. (2006) Altered synaptic development and active zone spacing in endocytosis mutants. Curr Biol 16: 591-8 PubMed GONUTS page
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