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FB:sti

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) sti ( synonyms: CG10522, CIT-K, CITRON, Citron, Citron K, Citron Kinase, Citron kinase, DCK, Drosophila citron kinase, STI, Sticky, anon-WO0118547.388, cit, citron, citron kinase, dck, l(3)7m-62, l(3)7m62, l(3)SG21 )
Protein Name(s) sticky,
External Links
FB FBgn0002466

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000281

cytokinesis after mitosis

FB:FBrf0180157
PMID:15459099[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0000910

cytokinesis

FB:FBrf0162189
PMID:12975351[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0000910

cytokinesis

FB:FBrf0167741
PMID:14527345[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0000910

cytokinesis

FB:FBrf0180064
PMID:15380073[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0000910

cytokinesis

FB:FBrf0180476
PMID:15547975[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0000910

cytokinesis

FB:FBrf0205282
PMID:18245345[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0000915

cytokinesis, actomyosin contractile ring assembly

FB:FBrf0179178
PMID:15240570[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0004674

protein serine/threonine kinase activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

EMBL:AF086824

F

From FB

GO:0004674

protein serine/threonine kinase activity

FB:FBrf0132098
PMID:10908587[8]

NAS: Non-traceable Author Statement

F

From FB

GO:0005083

small GTPase regulator activity

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001180

F

From FB

GO:0005524

ATP binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR017441
InterPro:IPR017892

F

From FB

GO:0005826

actomyosin contractile ring

FB:FBrf0180157
PMID:15459099[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0006325

chromatin organization

FB:FBrf0205282
PMID:18245345[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006468

protein phosphorylation

FB:FBrf0132098
PMID:10908587[8]

NAS: Non-traceable Author Statement

P

From FB

GO:0006468

protein phosphorylation

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR008271
InterPro:IPR017892

P

From FB

GO:0007109

cytokinesis, completion of separation

FB:FBrf0180505
PMID:15371536[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0019992

diacylglycerol binding

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

InterPro:IPR002219

F

From FB

GO:0032956

regulation of actin cytoskeleton organization

FB:FBrf0202814
PMID:18207738[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035556

intracellular signal transduction

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR002219

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Shandala T et al. (2004) Citron kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster. Development 131: 5053-63 PubMed GONUTS page
  2. Rogers SL et al. (2003) Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J Cell Biol 162: 1079-88 PubMed GONUTS page
  3. Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
  4. Echard A et al. (2004) Terminal cytokinesis events uncovered after an RNAi screen. Curr Biol 14: 1685-93 PubMed GONUTS page
  5. Eggert US et al. (2004) Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol 2: e379 PubMed GONUTS page
  6. 6.0 6.1 Sweeney SJ et al. (2008) Drosophila sticky/citron kinase is a regulator of cell-cycle progression, genetically interacts with Argonaute 1 and modulates epigenetic gene silencing. Genetics 178: 1311-25 PubMed GONUTS page
  7. D'Avino PP et al. (2004) Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. J Cell Biol 166: 61-71 PubMed GONUTS page
  8. 8.0 8.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
  9. Naim V et al. (2004) Drosophila citron kinase is required for the final steps of cytokinesis. Mol Biol Cell 15: 5053-63 PubMed GONUTS page
  10. Kunda P et al. (2008) Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis. Curr Biol 18: 91-101 PubMed GONUTS page
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