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FB:spz
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | spz ( synonyms: CG6134, CT19282, Protein spaetzle precursor, SPZ, Spaetzle, Spatzle, Spz, Spz1, mel(3)7, spaetzle, spazle, spaztle ) | |
| Protein Name(s) | spatzle, | |
| External Links | ||
| FB | FBgn0003495 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000578 |
embryonic axis specification |
FB:FBrf0159233 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0005121 |
Toll binding |
FB:FBrf0074384 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0262473 |
F |
From FB |
||
| GO:0005121 |
Toll binding |
FB:FBrf0110978 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005121 |
Toll binding |
FB:FBrf0124085 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005121 |
Toll binding |
FB:FBrf0141086 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005121 |
Toll binding |
FB:FBrf0141281 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005121 |
Toll binding |
FB:FBrf0161598 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005121 |
Toll binding |
FB:FBrf0167392 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005121 |
Toll binding |
FB:FBrf0179043 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005121 |
Toll binding |
FB:FBrf0205200 |
IPI: Inferred from Physical Interaction |
FB:FBgn0262473 |
F |
From FB |
||
| GO:0005125 |
cytokine activity |
FB:FBrf0161598 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005576 |
extracellular region |
FB:FBrf0068603 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005576 |
extracellular region |
FB:FBrf0074384 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005576 |
extracellular region |
FB:FBrf0118157 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005576 |
extracellular region |
FB:FBrf0174342 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0006952 |
defense response |
FB:FBrf0127230 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006952 |
defense response |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006952 |
defense response |
FB:FBrf0207060 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006955 |
immune response |
FB:FBrf0179043 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006967 |
positive regulation of antifungal peptide biosynthetic process |
FB:FBrf0110270 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007310 |
oocyte dorsal/ventral axis specification |
FB:FBrf0068603 |
IEP: Inferred from Expression Pattern |
P |
From FB |
|||
| GO:0007311 |
maternal specification of dorsal/ventral axis, oocyte, germ-line encoded |
FB:FBrf0055883 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008045 |
motor axon guidance |
FB:FBrf0206302 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0055883 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0068603 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0110978 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0133282 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0141068 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0141086 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0141281 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0148941 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0161045 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0008063 |
Toll signaling pathway |
FB:FBrf0167392 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008083 |
growth factor activity |
FB:FBrf0206302 |
IMP: Inferred from Mutant Phenotype |
F |
From FB |
|||
| GO:0008592 |
regulation of Toll signaling pathway |
FB:FBrf0201111 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009620 |
response to fungus |
FB:FBrf0132053 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0009950 |
dorsal/ventral axis specification |
FB:FBrf0074384 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003089 |
P |
From FB |
||
| GO:0009950 |
dorsal/ventral axis specification |
FB:FBrf0118157 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0009950 |
dorsal/ventral axis specification |
FB:FBrf0127230 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0009950 |
dorsal/ventral axis specification |
FB:FBrf0141281 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0009950 |
dorsal/ventral axis specification |
FB:FBrf0159233 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0009953 |
dorsal/ventral pattern formation |
FB:FBrf0206922 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0016015 |
morphogen activity |
FB:FBrf0159233 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0019732 |
antifungal humoral response |
FB:FBrf0090665 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0031334 |
positive regulation of protein complex assembly |
FB:FBrf0205200 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0042803 |
protein homodimerization activity |
FB:FBrf0206922 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0043234 |
protein complex |
FB:FBrf0205200 |
IPI: Inferred from Physical Interaction |
FB:FBgn0262473 |
C |
From FB |
||
| GO:0045087 |
innate immune response |
FB:FBrf0141086 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045087 |
innate immune response |
FB:FBrf0198620 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0045087 |
innate immune response |
FB:FBrf0208605 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0050830 |
defense response to Gram-positive bacterium |
FB:FBrf0174342 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0050830 |
defense response to Gram-positive bacterium |
FB:FBrf0192381 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050832 |
defense response to fungus |
FB:FBrf0192381 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Martinez Arias A (2003) Wnts as morphogens? The view from the wing of Drosophila. Nat Rev Mol Cell Biol 4: 321-5 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Schneider DS et al. (1994) A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo. Development 120: 1243-50 PubMed GONUTS page
- ↑ 3.0 3.1 van Eeden F & St Johnston D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr Opin Genet Dev 9: 396-404 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Beutler B & Poltorak A (2001) Toll we meet again.... Nat Immunol 2: 9-10 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Lall S & Patel NH (2001) Conservation and divergence in molecular mechanisms of axis formation. Annu Rev Genet 35: 407-37 PubMed GONUTS page
- ↑ 6.0 6.1 Underhill D (2003) Toll gets tied in a knot. Nat Immunol 4: 723-4 PubMed GONUTS page
- ↑ 7.0 7.1 Janssens S & Beyaert R (2003) Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 16: 637-46 PubMed GONUTS page
- ↑ 8.0 8.1 Leclerc V & Reichhart JM (2004) The immune response of Drosophila melanogaster. Immunol Rev 198: 59-71 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Gangloff M et al. (2008) Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Spätzle. J Biol Chem 283: 14629-35 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Morisato D & Anderson KV (1994) The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo. Cell 76: 677-88 PubMed GONUTS page
- ↑ 11.0 11.1 Brennan CA & Anderson KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu Rev Immunol 22: 457-83 PubMed GONUTS page
- ↑ 12.0 12.1 Meister M et al. (2000) The antimicrobial host defense of Drosophila. Curr Top Microbiol Immunol 248: 17-36 PubMed GONUTS page
- ↑ El Chamy L et al. (2008) Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll. Nat Immunol 9: 1165-70 PubMed GONUTS page
- ↑ Manfruelli P et al. (1999) A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. EMBO J 18: 3380-91 PubMed GONUTS page
- ↑ 15.0 15.1 Chasan R et al. (1992) Activation of the easter zymogen is regulated by five other genes to define dorsal-ventral polarity in the Drosophila embryo. Development 115: 607-16 PubMed GONUTS page
- ↑ 16.0 16.1 Zhu B et al. (2008) Drosophila neurotrophins reveal a common mechanism for nervous system formation. PLoS Biol 6: e284 PubMed GONUTS page
- ↑ Kimbrell DA & Beutler B (2001) The evolution and genetics of innate immunity. Nat Rev Genet 2: 256-67 PubMed GONUTS page
- ↑ Stathopoulos A & Levine M (2002) Dorsal gradient networks in the Drosophila embryo. Dev Biol 246: 57-67 PubMed GONUTS page
- ↑ Weber AN et al. (2003) Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling. Nat Immunol 4: 794-800 PubMed GONUTS page
- ↑ Weber AN et al. (2007) Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand. J Biol Chem 282: 13522-31 PubMed GONUTS page
- ↑ Medzhitov R & Janeway Jr C (2000) Fly immunity: great expectations. Genome Biol 1: REVIEWS106 PubMed GONUTS page
- ↑ 22.0 22.1 Hoffmann A et al. (2008) Biophysical characterization of refolded Drosophila Spätzle, a cystine knot protein, reveals distinct properties of three isoforms. J Biol Chem 283: 32598-609 PubMed GONUTS page
- ↑ Lemaitre B et al. (1996) The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86: 973-83 PubMed GONUTS page
- ↑ Chien Y et al. (2006) RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell 127: 157-70 PubMed GONUTS page
- ↑ Buchon N et al. (2009) A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway. Proc Natl Acad Sci U S A 106: 12442-7 PubMed GONUTS page
- ↑ 26.0 26.1 Leulier F et al. (2006) The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Mol Cell Biol 26: 7821-31 PubMed GONUTS page
