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FB:smo
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | smo ( synonyms: CG11561, SMO, Smo, Smoothened, dSmo, smooth ) | |
| Protein Name(s) | smoothened, | |
| External Links | ||
| FB | FBgn0003444 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001746 |
Bolwig's organ morphogenesis |
FB:FBrf0126773 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0004888 |
transmembrane signaling receptor activity |
FB:FBrf0129744 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004888 |
transmembrane signaling receptor activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0004930 |
G-protein coupled receptor activity |
FB:FBrf0089582 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004930 |
G-protein coupled receptor activity |
FB:FBrf0116197 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004930 |
G-protein coupled receptor activity |
FB:FBrf0141203 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004930 |
G-protein coupled receptor activity |
FB:FBrf0174381 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0167606 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000352 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0179063 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000352 |
F |
From FB |
||
| GO:0005768 |
endosome |
FB:FBrf0174381 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005886 |
plasma membrane |
FB:FBrf0116197 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005886 |
plasma membrane |
FB:FBrf0174381 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0007165 |
signal transduction |
FB:FBrf0129744 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0090495 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0108872 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0141064 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0141203 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007224 |
smoothened signaling pathway |
FB:FBrf0167606 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007346 |
regulation of mitotic cell cycle |
FB:FBrf0135358 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007350 |
blastoderm segmentation |
FB:FBrf0089881 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007455 |
eye-antennal disc morphogenesis |
FB:FBrf0146982 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003892 |
P |
From FB |
||
| GO:0008158 |
hedgehog receptor activity |
FB:FBrf0141064 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0016020 |
membrane |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
C |
From FB |
|||
| GO:0016021 |
integral to membrane |
FB:FBrf0089582 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0016021 |
integral to membrane |
FB:FBrf0111421 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0016021 |
integral to membrane |
FB:FBrf0129744 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0016021 |
integral to membrane |
FB:FBrf0141203 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
FB:FBrf0058095 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030707 |
ovarian follicle cell development |
FB:FBrf0190209 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035019 |
somatic stem cell maintenance |
FB:FBrf0190209 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045749 |
negative regulation of S phase of mitotic cell cycle |
FB:FBrf0187405 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048099 |
anterior/posterior lineage restriction, imaginal disc |
FB:FBrf0123139 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0048100 |
wing disc anterior/posterior pattern formation |
FB:FBrf0141064 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0048592 |
eye morphogenesis |
FB:FBrf0193969 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Suzuki T & Saigo K (2000) Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus. Development 127: 1531-40 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Brody T & Cravchik A (2000) Drosophila melanogaster G protein-coupled receptors. J Cell Biol 150: F83-8 PubMed GONUTS page
- ↑ 3.0 3.1 Alcedo J et al. (1996) The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86: 221-32 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Ogden SK et al. (2004) Regulation of Hedgehog signaling: a complex story. Biochem Pharmacol 67: 805-14 PubMed GONUTS page
- ↑ 5.0 5.1 Jia J et al. (2003) Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev 17: 2709-20 PubMed GONUTS page
- ↑ Ogden SK et al. (2003) Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr Biol 13: 1998-2003 PubMed GONUTS page
- ↑ Chen Y & Struhl G (1996) Dual roles for patched in sequestering and transducing Hedgehog. Cell 87: 553-63 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 McNeill H (2000) Sticking together and sorting things out: adhesion as a force in development. Nat Rev Genet 1: 100-8 PubMed GONUTS page
- ↑ Zhang Y & Kalderon D (2001) Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature 410: 599-604 PubMed GONUTS page
- ↑ van den Heuvel M & Ingham PW (1996) smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 382: 547-51 PubMed GONUTS page
- ↑ Shyamala BV & Bhat KM (2002) A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila. Development 129: 1839-47 PubMed GONUTS page
- ↑ Marsh JL & Theisen H (1999) Regeneration in insects. Semin Cell Dev Biol 10: 365-75 PubMed GONUTS page
- ↑ Sampedro J et al. (1993) A role for wingless in the segmental gradient of Drosophila? Development 117: 677-87 PubMed GONUTS page
- ↑ 14.0 14.1 Kirilly D et al. (2005) BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev Cell 9: 651-62 PubMed GONUTS page
- ↑ Firth LC & Baker NE (2005) Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell 8: 541-51 PubMed GONUTS page
- ↑ Milán M & Cohen SM (2000) Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control? Dev Biol 217: 1-9 PubMed GONUTS page
- ↑ Kent D et al. (2006) Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. Development 133: 2001-10 PubMed GONUTS page
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