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FB:slpr
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | slpr ( synonyms: CG2272, D-MLK, JNKKK, MLK, MLK2, Mixed lineage protein kinase 2, Mlk2, Slipper, Slpr, dMLK, dMLK2 ) | |
| Protein Name(s) | slipper, | |
| External Links | ||
| FB | FBgn0030018 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004672 |
protein kinase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004672 |
protein kinase activity |
FB:FBrf0158743 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004706 |
JUN kinase kinase kinase activity |
FB:FBrf0142861 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004706 |
JUN kinase kinase kinase activity |
FB:FBrf0144880 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:6849 |
F |
From FB |
||
| GO:0004706 |
JUN kinase kinase kinase activity |
FB:FBrf0144880 |
ISS: Inferred from Sequence or Structural Similarity |
HGNC:6850 |
F |
From FB |
||
| GO:0004706 |
JUN kinase kinase kinase activity |
FB:FBrf0155945 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004706 |
JUN kinase kinase kinase activity |
FB:FBrf0158743 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004712 |
protein serine/threonine/tyrosine kinase activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
NCBI_gi:4505263 |
F |
From FB |
||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005575 |
cellular component |
FB:FBrf0159398 |
ND: No biological Data available |
C |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0158743 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007254 |
JNK cascade |
FB:FBrf0144880 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0001291 |
P |
From FB |
||
| GO:0007254 |
JNK cascade |
FB:FBrf0144880 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010333 |
P |
From FB |
||
| GO:0007254 |
JNK cascade |
FB:FBrf0144880 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0243512 |
P |
From FB |
||
| GO:0007254 |
JNK cascade |
FB:FBrf0158743 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007256 |
activation of JNKK activity |
FB:FBrf0149002 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007257 |
activation of JUN kinase activity |
FB:FBrf0151872 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007257 |
activation of JUN kinase activity |
FB:FBrf0155945 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0144880 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0149002 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0151280 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0151872 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0193269 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007394 |
dorsal closure, elongation of leading edge cells |
FB:FBrf0144880 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042803 |
protein homodimerization activity |
FB:FBrf0144880 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0046330 |
positive regulation of JNK cascade |
FB:FBrf0189754 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046330 |
positive regulation of JNK cascade |
FB:FBrf0193269 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046529 |
imaginal disc fusion, thorax closure |
FB:FBrf0193269 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046777 |
protein autophosphorylation |
FB:FBrf0144880 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0046843 |
dorsal appendage formation |
FB:FBrf0193269 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048803 |
imaginal disc-derived male genitalia morphogenesis |
FB:FBrf0193269 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048804 |
imaginal disc-derived female genitalia morphogenesis |
FB:FBrf0193269 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0071361 |
cellular response to ethanol |
FB:FBrf0189754 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Sathyanarayana P et al. (2003) Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling. Biochim Biophys Acta 1640: 77-84 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Stronach B & Perrimon N (2002) Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev 16: 377-87 PubMed GONUTS page
- ↑ 4.0 4.1 Sathyanarayana P et al. (2002) Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3. Mol Cell 10: 1527-33 PubMed GONUTS page
- ↑ 5.0 5.1 Van Aelst L & Symons M (2002) Role of Rho family GTPases in epithelial morphogenesis. Genes Dev 16: 1032-54 PubMed GONUTS page
- ↑ 6.0 6.1 Martin P & Wood W (2002) Epithelial fusions in the embryo. Curr Opin Cell Biol 14: 569-74 PubMed GONUTS page
- ↑ Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Polaski S et al. (2006) Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development. Genetics 174: 719-33 PubMed GONUTS page
- ↑ 9.0 9.1 Ryabinina OP et al. (2006) D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol 7: 7 PubMed GONUTS page
