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FB:slmb
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | slmb ( synonyms: BcDNA:GM02031, CG3412, SLIMB, Slimb, Slimb/Beta-TRCP1, Slimb/beta-TRCP, Slmb, Supernumerary limbs, centrosome replication defective, crd, ica, icare, l(3)00295, pingiel, shiva, shv, slimb ) | |
| Protein Name(s) | supernumerary limbs, | |
| External Links | ||
| FB | FBgn0023423 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000151 |
ubiquitin ligase complex |
FB:FBrf0107871 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
FB:FBrf0108003 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0006508 |
proteolysis |
FB:FBrf0148948 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007088 |
regulation of mitosis |
FB:FBrf0187475 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007293 |
germarium-derived egg chamber formation |
FB:FBrf0187475 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0201428 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007304 |
chorion-containing eggshell formation |
FB:FBrf0187475 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007611 |
learning or memory |
FB:FBrf0159552 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0152243 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007623 |
circadian rhythm |
FB:FBrf0152243 |
IPI: Inferred from Physical Interaction |
FB:FBgn0002413 |
P |
From FB |
||
| GO:0007623 |
circadian rhythm |
FB:FBrf0152243 |
IPI: Inferred from Physical Interaction |
FB:FBgn0003068 |
P |
From FB |
||
| GO:0008355 |
olfactory learning |
FB:FBrf0159552 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008588 |
release of cytoplasmic sequestered NF-kappaB |
FB:FBrf0107871 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008588 |
release of cytoplasmic sequestered NF-kappaB |
FB:FBrf0108003 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008589 |
regulation of smoothened signaling pathway |
FB:FBrf0107871 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0019005 |
SCF ubiquitin ligase complex |
FB:FBrf0148948 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0019005 |
SCF ubiquitin ligase complex |
FB:FBrf0160832 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0030111 |
regulation of Wnt receptor signaling pathway |
FB:FBrf0100581 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030111 |
regulation of Wnt receptor signaling pathway |
FB:FBrf0107871 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030162 |
regulation of proteolysis |
FB:FBrf0160832 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030162 |
regulation of proteolysis |
FB:FBrf0167269 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030178 |
negative regulation of Wnt receptor signaling pathway |
FB:FBrf0136845 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
FB:FBrf0136845 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0030707 |
ovarian follicle cell development |
FB:FBrf0187475 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030708 |
germarium-derived female germ-line cyst encapsulation |
FB:FBrf0187475 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030713 |
ovarian follicle cell stalk formation |
FB:FBrf0187475 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030720 |
oocyte localization involved in germarium-derived egg chamber formation |
FB:FBrf0187475 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030727 |
germarium-derived female germ-line cyst formation |
FB:FBrf0187475 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045475 |
locomotor rhythm |
FB:FBrf0152243 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045849 |
negative regulation of nurse cell apoptotic process |
FB:FBrf0187475 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045879 |
negative regulation of smoothened signaling pathway |
FB:FBrf0100581 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046599 |
regulation of centriole replication |
FB:FBrf0206754 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0046843 |
dorsal appendage formation |
FB:FBrf0187475 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046983 |
protein dimerization activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0051219 |
phosphoprotein binding |
FB:FBrf0190207 |
IPI: Inferred from Physical Interaction |
FB:FBgn0004859 |
F |
From FB |
||
| GO:0060253 |
negative regulation of glial cell proliferation |
FB:FBrf0208044 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0041171 |
P |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Maniatis T (1999) A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways. Genes Dev 13: 505-10 PubMed GONUTS page
- ↑ 2.0 2.1 Spencer E et al. (1999) Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. Genes Dev 13: 284-94 PubMed GONUTS page
- ↑ 3.0 3.1 Noureddine MA et al. (2002) Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase. Dev Cell 2: 757-70 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Muzzopappa M & Wappner P (2005) Multiple roles of the F-box protein Slimb in Drosophila egg chamber development. Development 132: 2561-71 PubMed GONUTS page
- ↑ Mathieu J et al. (2007) A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics 176: 1579-90 PubMed GONUTS page
- ↑ 6.0 6.1 Dubnau J et al. (2003) The staufen/pumilio pathway is involved in Drosophila long-term memory. Curr Biol 13: 286-96 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Grima B et al. (2002) The F-box protein slimb controls the levels of clock proteins period and timeless. Nature 420: 178-82 PubMed GONUTS page
- ↑ 8.0 8.1 Ou CY et al. (2003) Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. Trends Genet 19: 382-9 PubMed GONUTS page
- ↑ 9.0 9.1 Jiang J & Struhl G (1998) Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391: 493-6 PubMed GONUTS page
- ↑ Lee LA & Orr-Weaver TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu Rev Genet 37: 545-78 PubMed GONUTS page
- ↑ 11.0 11.1 Potter CJ & Xu T (2001) Mechanisms of size control. Curr Opin Genet Dev 11: 279-86 PubMed GONUTS page
- ↑ Rogers GC et al. (2009) The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. J Cell Biol 184: 225-39 PubMed GONUTS page
- ↑ Jia J et al. (2005) Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell 9: 819-30 PubMed GONUTS page
- ↑ Ho MS et al. (2009) Gcm protein degradation suppresses proliferation of glial progenitors. Proc Natl Acad Sci U S A 106: 6778-83 PubMed GONUTS page
