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FB:sli
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | sli ( synonyms: CG33464, CG43758, CG8355, CT21700, CT37068, SGP cluster fusion defects 3, Slit, dSlit, fus3, l(2)05248, lethal (2) 05248, wdh ) | |
| Protein Name(s) | slit, | |
| External Links | ||
| FB | FBgn0264089 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0007432 |
salivary gland boundary specification |
FB:FBrf0187388 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0071666 |
Slit-Robo signaling complex |
FB:FBrf0200053 |
IDA: Inferred from Direct Assay |
C |
From FB |
complete | ||
| GO:0048495 |
Roundabout binding |
FB:FBrf0200053 |
IPI: Inferred from Physical Interaction |
FB:FBgn0005631
|
F |
From FB |
complete | |
| GO:0008201 |
heparin binding |
FB:FBrf0200053 |
IDA: Inferred from Direct Assay |
F |
From FB |
complete | ||
| GO:0016199 |
axon midline choice point recognition |
FB:FBrf0202566 PMID:17409115[3] |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
complete | ||
| GO:0001764 |
neuron migration |
FB:FBrf0180051 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0003151 |
outflow tract morphogenesis |
FB:FBrf0204371 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0005509 |
calcium ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0205517 |
IPI: Inferred from Physical Interaction |
FB:FBgn0005631 |
F |
From FB |
||
| GO:0005578 |
proteinaceous extracellular matrix |
FB:FBrf0081993 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0107807 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0136993 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0005631 |
P |
From FB |
||
| GO:0007411 |
axon guidance |
FB:FBrf0136993 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0136993 |
IPI: Inferred from Physical Interaction |
FB:FBgn0005631 |
P |
From FB |
||
| GO:0007411 |
axon guidance |
FB:FBrf0149077 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007427 |
epithelial cell migration, open tracheal system |
FB:FBrf0179216 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007432 |
salivary gland boundary specification |
FB:FBrf0187388 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007502 |
digestive tract mesoderm development |
FB:FBrf0213539 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007509 |
mesoderm migration involved in gastrulation |
FB:FBrf0051847 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007509 |
mesoderm migration involved in gastrulation |
FB:FBrf0135949 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008078 |
mesodermal cell migration |
FB:FBrf0107807 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008201 |
heparin binding |
FB:FBrf0200053 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0008347 |
glial cell migration |
FB:FBrf0051847 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008406 |
gonad development |
FB:FBrf0213539 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010632 |
regulation of epithelial cell migration |
FB:FBrf0151931 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016199 |
axon midline choice point recognition |
FB:FBrf0179366 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016199 |
axon midline choice point recognition |
FB:FBrf0191925 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016199 |
axon midline choice point recognition |
FB:FBrf0193348 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016199 |
axon midline choice point recognition |
FB:FBrf0202566 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0022409 |
positive regulation of cell-cell adhesion |
FB:FBrf0194038 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030182 |
neuron differentiation |
FB:FBrf0139628 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0031012 |
extracellular matrix |
FB:FBrf0051847 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0035050 |
embryonic heart tube development |
FB:FBrf0190040 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035050 |
embryonic heart tube development |
FB:FBrf0190142 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035050 |
embryonic heart tube development |
FB:FBrf0194038 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035385 |
Roundabout signaling pathway |
FB:FBrf0107807 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0005631 |
P |
From FB |
||
| GO:0046331 |
lateral inhibition |
FB:FBrf0214518 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048495 |
Roundabout binding |
FB:FBrf0200053 |
IPI: Inferred from Physical Interaction |
FB:FBgn0005631 |
F |
From FB |
||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0207099 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050919 |
negative chemotaxis |
FB:FBrf0051847 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0071666 |
Slit-Robo signaling complex |
FB:FBrf0200053 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:2000274 |
regulation of epithelial cell migration, open tracheal system |
FB:FBrf0151931 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kolesnikov T & Beckendorf SK (2005) NETRIN and SLIT guide salivary gland migration. Dev Biol 284: 102-11 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Hussain SA et al. (2006) A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. J Biol Chem 281: 39693-8 PubMed GONUTS page
- ↑ Lee S et al. (2007) The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion. Development 134: 1767-77 PubMed GONUTS page
- ↑ Kraut R & Zinn K (2004) Roundabout 2 regulates migration of sensory neurons by signaling in trans. Curr Biol 14: 1319-29 PubMed GONUTS page
- ↑ Zmojdzian M et al. (2008) Cellular components and signals required for the cardiac outflow tract assembly in Drosophila. Proc Natl Acad Sci U S A 105: 2475-80 PubMed GONUTS page
- ↑ Fukuhara N et al. (2008) Structural and functional analysis of slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo. J Biol Chem 283: 16226-34 PubMed GONUTS page
- ↑ Fessler LI et al. (1994) Drosophila extracellular matrix. Methods Enzymol 245: 271-94 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Kidd T et al. (1999) Slit is the midline repellent for the robo receptor in Drosophila. Cell 96: 785-94 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Battye R et al. (2001) Repellent signaling by Slit requires the leucine-rich repeats. J Neurosci 21: 4290-8 PubMed GONUTS page
- ↑ Stevens A & Jacobs JR (2002) Integrins regulate responsiveness to slit repellent signals. J Neurosci 22: 4448-55 PubMed GONUTS page
- ↑ Gallio M et al. (2004) Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline. Development 131: 3605-14 PubMed GONUTS page
- ↑ 12.0 12.1 Weyers JJ et al. (2011) A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. Dev Biol 353: 217-28 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 Rothberg JM et al. (1990) slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev 4: 2169-87 PubMed GONUTS page
- ↑ Kramer SG et al. (2001) Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration. Science 292: 737-40 PubMed GONUTS page
- ↑ 15.0 15.1 Englund C et al. (2002) Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea. Development 129: 4941-51 PubMed GONUTS page
- ↑ Orgogozo V et al. (2004) Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila. Mech Dev 121: 427-36 PubMed GONUTS page
- ↑ Garbe DS et al. (2007) beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS. Development 134: 273-84 PubMed GONUTS page
- ↑ Simionato E et al. (2007) The Drosophila RNA-binding protein ELAV is required for commissural axon midline crossing via control of commissureless mRNA expression in neurons. Dev Biol 301: 166-77 PubMed GONUTS page
- ↑ 19.0 19.1 Santiago-Martínez E et al. (2006) Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration. Proc Natl Acad Sci U S A 103: 12441-6 PubMed GONUTS page
- ↑ Mehta B & Bhat KM (2001) Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS. Development 128: 3161-8 PubMed GONUTS page
- ↑ Qian L et al. (2005) Slit and Robo control cardiac cell polarity and morphogenesis. Curr Biol 15: 2271-8 PubMed GONUTS page
- ↑ MacMullin A & Jacobs JR (2006) Slit coordinates cardiac morphogenesis in Drosophila. Dev Biol 293: 154-64 PubMed GONUTS page
- ↑ Dimitrova S et al. (2008) Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila. Dev Biol 324: 18-30 PubMed GONUTS page
