GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:sens
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | sens ( synonyms: 1228/04, CG10714, CG32120, Ly, Ly-1, Lyra, SENS, Sen, Sens, Senseless, Sensless, l(3)70Ad, sen, sensSenseless, sense ) | |
| Protein Name(s) | senseless, | |
| External Links | ||
| FB | FBgn0002573 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
FB:FBrf0205665 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0144824 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
FB:FBrf0205665 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0125535 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0204453 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0205665 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
FB:FBrf0125535 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0207285 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007422 |
peripheral nervous system development |
FB:FBrf0083410 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007422 |
peripheral nervous system development |
FB:FBrf0129996 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007422 |
peripheral nervous system development |
FB:FBrf0131381 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007423 |
sensory organ development |
FB:FBrf0179485 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007423 |
sensory organ development |
FB:FBrf0190268 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007423 |
sensory organ development |
FB:FBrf0190299 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000413 |
P |
From FB |
||
| GO:0007423 |
sensory organ development |
FB:FBrf0190299 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004170 |
P |
From FB |
||
| GO:0007423 |
sensory organ development |
FB:FBrf0190299 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008270 |
zinc ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0008407 |
chaeta morphogenesis |
FB:FBrf0190182 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008594 |
photoreceptor cell morphogenesis |
FB:FBrf0141686 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003267 |
P |
From FB |
||
| GO:0008594 |
photoreceptor cell morphogenesis |
FB:FBrf0141686 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016360 |
sensory organ precursor cell fate determination |
FB:FBrf0190299 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042051 |
compound eye photoreceptor development |
FB:FBrf0167533 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042059 |
negative regulation of epidermal growth factor receptor signaling pathway |
FB:FBrf0154884 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0043066 |
negative regulation of apoptotic process |
FB:FBrf0207191 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043425 |
bHLH transcription factor binding |
FB:FBrf0190268 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0205665 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0045465 |
R8 cell differentiation |
FB:FBrf0144824 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045465 |
R8 cell differentiation |
FB:FBrf0154884 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048666 |
neuron development |
FB:FBrf0190556 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0190556 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
|
NOT |
GO:0045464 |
R8 cell fate specification |
FB:FBrf0154884 |
NAS: Non-traceable Author Statement |
P |
From FB |
||
|
contributes_to |
GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
FB:FBrf0211936 |
IDA: Inferred from Direct Assay |
F |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Li-Kroeger D et al. (2008) Hox and senseless antagonism functions as a molecular switch to regulate EGF secretion in the Drosophila PNS. Dev Cell 15: 298-308 PubMed GONUTS page
- ↑ 2.0 2.1 Frankfort BJ & Mardon G (2002) R8 development in the Drosophila eye: a paradigm for neural selection and differentiation. Development 129: 1295-306 PubMed GONUTS page
- ↑ Tomasi T et al. (2008) The transmembrane protein Golden goal regulates R8 photoreceptor axon-axon and axon-target interactions. Neuron 57: 691-704 PubMed GONUTS page
- ↑ Morey M et al. (2008) Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons. Nature 456: 795-9 PubMed GONUTS page
- ↑ Salzberg A et al. (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13: 269-87 PubMed GONUTS page
- ↑ Nolo R et al. (2000) Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102: 349-62 PubMed GONUTS page
- ↑ Prokopenko SN et al. (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156: 1691-715 PubMed GONUTS page
- ↑ Treisman JE (2004) Coming to our senses. Bioessays 26: 825-8 PubMed GONUTS page
- ↑ 9.0 9.1 Acar M et al. (2006) Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development 133: 1979-89 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Jafar-Nejad H et al. (2006) Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development 133: 1683-92 PubMed GONUTS page
- ↑ Wildonger J & Mann RS (2005) Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling. Dev Biol 286: 507-20 PubMed GONUTS page
- ↑ 12.0 12.1 Frankfort BJ et al. (2001) senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye. Neuron 32: 403-14 PubMed GONUTS page
- ↑ Frankfort BJ & Mardon G (2004) Senseless represses nuclear transduction of Egfr pathway activation. Development 131: 563-70 PubMed GONUTS page
- ↑ Sprecher SG & Desplan C (2008) Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons. Nature 454: 533-7 PubMed GONUTS page
- ↑ 15.0 15.1 Parrish JZ et al. (2006) Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev 20: 820-35 PubMed GONUTS page
- ↑ McDonald EC et al. (2010) Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events. Dev Biol 347: 122-32 PubMed GONUTS page
