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FB:scrib
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | scrib ( synonyms: 0424/05, CG31082, CG42614, CG43398, CG5462, CG5467, CT17324, MENE (3R)-F, SCR, Scb, Scrb, Scrib, Scribble, Scribbled, Scribbles, gp150-like, immune response deficient 15, ird, ird15, l(3)673, l(3)S042405, l(3)c00119, l(3)j7B3, lethal (3) c00119, scrb, scribble, smell impaired 97B, smi97B, vart, vartul ) | |
| Protein Name(s) | scribbled, | |
| External Links | ||
| FB | FBgn0263289 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000902 |
cell morphogenesis |
FB:FBrf0184060 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0001737 |
establishment of imaginal disc-derived wing hair orientation |
FB:FBrf0208559 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0001738 |
morphogenesis of a polarized epithelium |
FB:FBrf0167430 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0146937 |
IPI: Inferred from Physical Interaction |
FB:FBgn0026239 |
F |
From FB |
||
| GO:0005918 |
septate junction |
FB:FBrf0125422 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005918 |
septate junction |
FB:FBrf0141282 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005918 |
septate junction |
FB:FBrf0157330 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005918 |
septate junction |
FB:FBrf0159315 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005918 |
septate junction |
FB:FBrf0159915 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0006963 |
positive regulation of antibacterial peptide biosynthetic process |
FB:FBrf0106339 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007280 |
pole cell migration |
FB:FBrf0155042 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0151280 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0184060 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007464 |
R3/R4 cell fate commitment |
FB:FBrf0208559 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007472 |
wing disc morphogenesis |
FB:FBrf0184060 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008105 |
asymmetric protein localization |
FB:FBrf0155643 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008105 |
asymmetric protein localization |
FB:FBrf0155996 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008283 |
cell proliferation |
FB:FBrf0128403 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008283 |
cell proliferation |
FB:FBrf0194142 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0159915 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008406 |
gonad development |
FB:FBrf0155042 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0016323 |
basolateral plasma membrane |
FB:FBrf0167430 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0016323 |
basolateral plasma membrane |
FB:FBrf0180375 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016327 |
apicolateral plasma membrane |
FB:FBrf0128403 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016328 |
lateral plasma membrane |
FB:FBrf0128403 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016331 |
morphogenesis of embryonic epithelium |
FB:FBrf0128403 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016332 |
establishment or maintenance of polarity of embryonic epithelium |
FB:FBrf0128403 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016333 |
morphogenesis of follicular epithelium |
FB:FBrf0128403 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016334 |
establishment or maintenance of polarity of follicular epithelium |
FB:FBrf0128403 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016335 |
morphogenesis of larval imaginal disc epithelium |
FB:FBrf0128403 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016336 |
establishment or maintenance of polarity of larval imaginal disc epithelium |
FB:FBrf0128403 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0019991 |
septate junction assembly |
FB:FBrf0184060 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0022402 |
cell cycle process |
FB:FBrf0185149 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030100 |
regulation of endocytosis |
FB:FBrf0207551 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0031594 |
neuromuscular junction |
FB:FBrf0201824 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0035088 |
establishment or maintenance of apical/basal cell polarity |
FB:FBrf0184060 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042048 |
olfactory behavior |
FB:FBrf0086870 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042048 |
olfactory behavior |
FB:FBrf0162145 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042067 |
establishment of ommatidial planar polarity |
FB:FBrf0208559 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045169 |
fusome |
FB:FBrf0211303 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0045186 |
zonula adherens assembly |
FB:FBrf0184060 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
FB:FBrf0141282 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
FB:FBrf0141377 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
FB:FBrf0159915 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0045198 |
establishment of epithelial cell apical/basal polarity |
FB:FBrf0185149 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045571 |
negative regulation of imaginal disc growth |
FB:FBrf0184060 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048749 |
compound eye development |
FB:FBrf0184060 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048863 |
stem cell differentiation |
FB:FBrf0211181 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050680 |
negative regulation of epithelial cell proliferation |
FB:FBrf0184060 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050803 |
regulation of synapse structure and activity |
FB:FBrf0151381 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051726 |
regulation of cell cycle |
FB:FBrf0159915 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0072002 |
Malpighian tubule development |
FB:FBrf0208408 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0072002 |
Malpighian tubule development |
FB:FBrf0211181 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0072089 |
stem cell proliferation |
FB:FBrf0211181 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Zeitler J et al. (2004) Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. J Cell Biol 167: 1137-46 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Courbard JR et al. (2009) The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors. Dev Biol 333: 67-77 PubMed GONUTS page
- ↑ 3.0 3.1 Gibson MC & Perrimon N (2003) Apicobasal polarization: epithelial form and function. Curr Opin Cell Biol 15: 747-52 PubMed GONUTS page
- ↑ Mathew D et al. (2002) Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Curr Biol 12: 531-9 PubMed GONUTS page
- ↑ Bilder D & Perrimon N (2000) Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403: 676-80 PubMed GONUTS page
- ↑ 6.0 6.1 Tepass U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet 35: 747-84 PubMed GONUTS page
- ↑ Caruana G (2002) Genetic studies define MAGUK proteins as regulators of epithelial cell polarity. Int J Dev Biol 46: 511-8 PubMed GONUTS page
- ↑ Cereijido M et al. (2003) Membrane targeting. Prog Biophys Mol Biol 81: 81-115 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Humbert P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25: 542-53 PubMed GONUTS page
- ↑ Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
- ↑ Wedlich D (2002) The polarising role of cell adhesion molecules in early development. Curr Opin Cell Biol 14: 563-8 PubMed GONUTS page
- ↑ Albertson R & Doe CQ (2003) Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat Cell Biol 5: 166-70 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 13.5 13.6 13.7 13.8 Bilder D et al. (2000) Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289: 113-6 PubMed GONUTS page
- ↑ Uhlirova M & Bohmann D (2006) JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J 25: 5294-304 PubMed GONUTS page
- ↑ Sotillos S et al. (2004) DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol 166: 549-57 PubMed GONUTS page
- ↑ 16.0 16.1 Dow LE et al. (2003) hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene 22: 9225-30 PubMed GONUTS page
- ↑ Igaki T et al. (2009) Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell 16: 458-65 PubMed GONUTS page
- ↑ Kohsaka H et al. (2007) In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2. J Cell Biol 179: 1289-300 PubMed GONUTS page
- ↑ Anholt RR et al. (1996) Effects of single P-element insertions on olfactory behavior in Drosophila melanogaster. Genetics 143: 293-301 PubMed GONUTS page
- ↑ Ganguly I et al. (2003) Scribble is essential for olfactory behavior in Drosophila melanogaster. Genetics 164: 1447-57 PubMed GONUTS page
- ↑ Lighthouse DV et al. (2008) New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev Biol 317: 59-71 PubMed GONUTS page
- ↑ Johnston LA & Gallant P (2002) Control of growth and organ size in Drosophila. Bioessays 24: 54-64 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 Zeng X et al. (2010) Tumor suppressors Sav/Scrib and oncogene Ras regulate stem-cell transformation in adult Drosophila malpighian tubules. J Cell Physiol 224: 766-74 PubMed GONUTS page
- ↑ Roche JP et al. (2002) Regulation of synaptic plasticity and synaptic vesicle dynamics by the PDZ protein Scribble. J Neurosci 22: 6471-9 PubMed GONUTS page
- ↑ Campbell K et al. (2009) Crumbs stabilises epithelial polarity during tissue remodelling. J Cell Sci 122: 2604-12 PubMed GONUTS page
