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FB:sc
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | sc ( synonyms: AS-C T4, AS-C T4sc, Ac/Sc, Achaete/Scute, CG3827, DROACS2, EG:198A6.1, Hairy-wing, Hw, Sc, Scute, T4, T4 AS-C, achaete-scute, asc, ascT4, bHLHc28, l(1)1Ba, sc/T4, scalpha, scute alpha, scute-T4-transcript, scute/sisterless-b, scute/sisterlessB, sis b, sis-b, sisB, sisb, sisterless-b ) | |
| Protein Name(s) | scute, | |
| External Links | ||
| FB | FBgn0004170 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
FB:FBrf0055582 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0003677 |
DNA binding |
FB:FBrf0123500 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0053886 |
ISS: Inferred from Sequence or Structural Similarity |
FB:FBgn0002561 |
F |
From FB |
||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0187959 |
IPI: Inferred from Physical Interaction |
FB:FBgn0025463 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From FB |
|||
| GO:0005667 |
transcription factor complex |
FB:FBrf0053886 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000413 |
C |
From FB |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
FB:FBrf0053886 |
ISS: Inferred from Sequence or Structural Similarity |
FB:FBgn0002561 |
P |
From FB |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
FB:FBrf0151319 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0007346 |
regulation of mitotic cell cycle |
FB:FBrf0167269 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007399 |
nervous system development |
FB:FBrf0055054 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003411 |
P |
From FB |
||
| GO:0007399 |
nervous system development |
FB:FBrf0055582 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007399 |
nervous system development |
FB:FBrf0161619 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007400 |
neuroblast fate determination |
FB:FBrf0123500 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007400 |
neuroblast fate determination |
FB:FBrf0158840 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007417 |
central nervous system development |
FB:FBrf0123500 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007417 |
central nervous system development |
FB:FBrf0151529 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007419 |
ventral cord development |
FB:FBrf0158840 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007422 |
peripheral nervous system development |
FB:FBrf0123500 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007422 |
peripheral nervous system development |
FB:FBrf0151529 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007422 |
peripheral nervous system development |
FB:FBrf0190143 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007423 |
sensory organ development |
FB:FBrf0190299 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007530 |
sex determination |
FB:FBrf0055054 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007530 |
sex determination |
FB:FBrf0055582 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010109 |
P |
From FB |
||
| GO:0007530 |
sex determination |
FB:FBrf0055582 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010109 |
P |
From FB |
||
| GO:0007530 |
sex determination |
FB:FBrf0064442 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003659 |
P |
From FB |
||
| GO:0007530 |
sex determination |
FB:FBrf0123500 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007530 |
sex determination |
FB:FBrf0131266 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007530 |
sex determination |
FB:FBrf0151529 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007540 |
sex determination, establishment of X:A ratio |
FB:FBrf0055582 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007540 |
sex determination, establishment of X:A ratio |
FB:FBrf0125416 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007549 |
dosage compensation |
FB:FBrf0123500 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008134 |
transcription factor binding |
FB:FBrf0155707 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0002633 |
F |
From FB |
||
| GO:0008134 |
transcription factor binding |
FB:FBrf0155707 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0002735 |
F |
From FB |
||
| GO:0008407 |
chaeta morphogenesis |
FB:FBrf0135681 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008407 |
chaeta morphogenesis |
FB:FBrf0151319 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0008407 |
chaeta morphogenesis |
FB:FBrf0190122 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008407 |
chaeta morphogenesis |
FB:FBrf0190143 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008407 |
chaeta morphogenesis |
FB:FBrf0190182 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0022416 |
chaeta development |
FB:FBrf0212072 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043066 |
negative regulation of apoptotic process |
FB:FBrf0190299 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0075104 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
FB:FBrf0065441 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046982 |
protein heterodimerization activity |
FB:FBrf0053776 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000413 |
F |
From FB |
||
| GO:0046982 |
protein heterodimerization activity |
FB:FBrf0053886 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000413 |
F |
From FB |
||
| GO:0046982 |
protein heterodimerization activity |
FB:FBrf0065441 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000413 |
F |
From FB |
||
| GO:0046982 |
protein heterodimerization activity |
FB:FBrf0075104 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000413 |
F |
From FB |
||
| GO:0061382 |
Malpighian tubule tip cell differentiation |
FB:FBrf0075100 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
|
contributes_to |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
FB:FBrf0065441 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000413 |
F |
From FB |
|
|
contributes_to |
GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
FB:FBrf0084040 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000413 |
F |
From FB |
|
|
contributes_to |
GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0053776 |
IDA: Inferred from Direct Assay |
F |
From FB |
||
|
contributes_to |
GO:0043565 |
sequence-specific DNA binding |
FB:FBrf0053886 |
IPI: Inferred from Physical Interaction |
FB:FBgn0000413 |
F |
From FB |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Younger-Shepherd S et al. (1992) deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination. Cell 70: 911-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Cabrera CV & Alonso MC (1991) Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila. EMBO J 10: 2965-73 PubMed GONUTS page
- ↑ Möller A et al. (2005) Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repression. J Mol Biol 352: 329-37 PubMed GONUTS page
- ↑ 4.0 4.1 Calleja M et al. (2002) How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila. Gene 292: 1-12 PubMed GONUTS page
- ↑ Lee LA & Orr-Weaver TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu Rev Genet 37: 545-78 PubMed GONUTS page
- ↑ 6.0 6.1 Erickson JW & Cline TW (1991) Molecular nature of the Drosophila sex determination signal and its link to neurogenesis. Science 251: 1071-4 PubMed GONUTS page
- ↑ 7.0 7.1 Skeath JB & Thor S (2003) Genetic control of Drosophila nerve cord development. Curr Opin Neurobiol 13: 8-15 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Skaer N et al. (2002) Gene duplication at the achaete-scute complex and morphological complexity of the peripheral nervous system in Diptera. Trends Genet 18: 399-405 PubMed GONUTS page
- ↑ 9.0 9.1 Marcellini S et al. (2005) achaete, but not scute, is dispensable for the peripheral nervous system of Drosophila. Dev Biol 285: 545-53 PubMed GONUTS page
- ↑ 10.0 10.1 Jafar-Nejad H et al. (2006) Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development 133: 1683-92 PubMed GONUTS page
- ↑ Erickson JW & Cline TW (1993) A bZIP protein, sisterless-a, collaborates with bHLH transcription factors early in Drosophila development to determine sex. Genes Dev 7: 1688-702 PubMed GONUTS page
- ↑ Canon J & Banerjee U (2000) Runt and Lozenge function in Drosophila development. Semin Cell Dev Biol 11: 327-36 PubMed GONUTS page
- ↑ Schütt C & Nöthiger R (2000) Structure, function and evolution of sex-determining systems in Dipteran insects. Development 127: 667-77 PubMed GONUTS page
- ↑ 14.0 14.1 Giagtzoglou N et al. (2003) Two modes of recruitment of E(spl) repressors onto target genes. Development 130: 259-70 PubMed GONUTS page
- ↑ Baker BS et al. (2001) Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell 105: 13-24 PubMed GONUTS page
- ↑ Gibert JM et al. (2005) A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor poils-au-dos, a repressor of achaete-scute. Dev Biol 288: 194-205 PubMed GONUTS page
- ↑ Wildonger J & Mann RS (2005) Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling. Dev Biol 286: 507-20 PubMed GONUTS page
- ↑ de Navascués J & Modolell J (2010) The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. Mech Dev 127: 393-406 PubMed GONUTS page
- ↑ 19.0 19.1 Cabrera CV et al. (1994) Regulation of scute function by extramacrochaete in vitro and in vivo. Development 120: 3595-603 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 Jarman AP et al. (1993) The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors. Development 119: 19-29 PubMed GONUTS page
- ↑ 21.0 21.1 Van Doren M et al. (1991) The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes. Development 113: 245-55 PubMed GONUTS page
- ↑ Hoch M et al. (1994) Sequential fates in a single cell are established by the neurogenic cascade in the Malpighian tubules of Drosophila. Development 120: 3439-50 PubMed GONUTS page
- ↑ Hoshijima K et al. (1995) Transcriptional regulation of the Sex-lethal gene by helix-loop-helix proteins. Nucleic Acids Res 23: 3441-8 PubMed GONUTS page
