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FB:rok
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | rok ( synonyms: CG9774, DROK, DRhk, DRho-kinase, DRok, Drok, RHO kinase, ROCK, ROCK-1, ROCK1, ROK, ROKalpha/beta, Rhk, Rho kinase, Rho-associated kinase, RhoA kinase, RhoK, Rock, Rok, dROK, dRok, drok, rho kinase ) | |
| Protein Name(s) | Rho-kinase, | |
| External Links | ||
| FB | FBgn0026181 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000022 |
mitotic spindle elongation |
FB:FBrf0190018 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0000092 |
mitotic anaphase B |
FB:FBrf0190018 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0000910 |
cytokinesis |
FB:FBrf0180064 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0000910 |
cytokinesis |
FB:FBrf0190018 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0000910 |
cytokinesis |
FB:FBrf0191432 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0000910 |
cytokinesis |
FB:FBrf0192994 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0001736 |
establishment of planar polarity |
FB:FBrf0156094 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0001736 |
establishment of planar polarity |
FB:FBrf0156198 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0001737 |
establishment of imaginal disc-derived wing hair orientation |
FB:FBrf0135688 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0001932 |
regulation of protein phosphorylation |
FB:FBrf0135688 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
EMBL:U58512 |
F |
From FB |
||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0107487 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0111979 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0111979 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0118100 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0126475 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0135688 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0111979 |
IPI: Inferred from Physical Interaction |
FB:FBgn0014020 |
F |
From FB |
||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000719 |
F |
From FB |
||
| GO:0005543 |
phospholipid binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0107487 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007067 |
mitosis |
FB:FBrf0190018 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007266 |
Rho protein signal transduction |
FB:FBrf0111979 |
IPI: Inferred from Physical Interaction |
FB:FBgn0014020 |
P |
From FB |
||
| GO:0007300 |
ovarian nurse cell to oocyte transport |
FB:FBrf0192194 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007302 |
nurse cell nucleus anchoring |
FB:FBrf0192194 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007309 |
oocyte axis specification |
FB:FBrf0192194 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0149002 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0151280 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008335 |
female germline ring canal stabilization |
FB:FBrf0192194 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008360 |
regulation of cell shape |
FB:FBrf0190283 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008544 |
epidermis development |
FB:FBrf0194691 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016318 |
ommatidial rotation |
FB:FBrf0149002 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0016331 |
morphogenesis of embryonic epithelium |
FB:FBrf0190283 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0019992 |
diacylglycerol binding |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0030036 |
actin cytoskeleton organization |
FB:FBrf0192194 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0032065 |
cortical protein anchoring |
FB:FBrf0151365 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0032231 |
regulation of actin filament bundle assembly |
FB:FBrf0135688 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000499 |
P |
From FB |
||
| GO:0032231 |
regulation of actin filament bundle assembly |
FB:FBrf0135688 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0001085 |
P |
From FB |
||
| GO:0032231 |
regulation of actin filament bundle assembly |
FB:FBrf0135688 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0032956 |
regulation of actin cytoskeleton organization |
FB:FBrf0202814 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035191 |
nuclear axial expansion |
FB:FBrf0151365 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035317 |
imaginal disc-derived wing hair organization |
FB:FBrf0135688 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000499 |
P |
From FB |
||
| GO:0035317 |
imaginal disc-derived wing hair organization |
FB:FBrf0135688 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0001085 |
P |
From FB |
||
| GO:0035317 |
imaginal disc-derived wing hair organization |
FB:FBrf0135688 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042067 |
establishment of ommatidial planar polarity |
FB:FBrf0135688 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042325 |
regulation of phosphorylation |
FB:FBrf0192994 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0045184 |
establishment of protein localization |
FB:FBrf0191432 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048599 |
oocyte development |
FB:FBrf0192194 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0050770 |
regulation of axonogenesis |
FB:FBrf0180582 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0041203 |
P |
From FB |
||
| GO:0051020 |
GTPase binding |
FB:FBrf0135688 |
IPI: Inferred from Physical Interaction |
FB:FBgn0014020 |
F |
From FB |
||
| GO:2000040 |
regulation of planar cell polarity pathway involved in axis elongation |
FB:FBrf0211783 |
IDA: Inferred from Direct Assay |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Hickson GR et al. (2006) Rho-kinase controls cell shape changes during cytokinesis. Curr Biol 16: 359-70 PubMed GONUTS page
- ↑ Echard A et al. (2004) Terminal cytokinesis events uncovered after an RNAi screen. Curr Biol 14: 1685-93 PubMed GONUTS page
- ↑ 3.0 3.1 Dean SO et al. (2005) Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc Natl Acad Sci U S A 102: 13473-8 PubMed GONUTS page
- ↑ 4.0 4.1 Dean SO & Spudich JA (2006) Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylation. PLoS One 1: e131 PubMed GONUTS page
- ↑ Mlodzik M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet 18: 564-71 PubMed GONUTS page
- ↑ Tree DR et al. (2002) A three-tiered mechanism for regulation of planar cell polarity. Semin Cell Dev Biol 13: 217-24 PubMed GONUTS page
- ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 Winter CG et al. (2001) Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell 105: 81-91 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Mizuno T et al. (1999) Identification and characterization of Drosophila homolog of Rho-kinase. Gene 238: 437-44 PubMed GONUTS page
- ↑ 9.0 9.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Verdier V et al. (2006) Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis. Dev Biol 297: 417-32 PubMed GONUTS page
- ↑ 11.0 11.1 Van Aelst L & Symons M (2002) Role of Rho family GTPases in epithelial morphogenesis. Genes Dev 16: 1032-54 PubMed GONUTS page
- ↑ Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
- ↑ 13.0 13.1 Dawes-Hoang RE et al. (2005) folded gastrulation, cell shape change and the control of myosin localization. Development 132: 4165-78 PubMed GONUTS page
- ↑ Ninov N et al. (2007) Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis. Development 134: 367-79 PubMed GONUTS page
- ↑ 15.0 15.1 Royou A et al. (2002) Cortical recruitment of nonmuscle myosin II in early syncytial Drosophila embryos: its role in nuclear axial expansion and its regulation by Cdc2 activity. J Cell Biol 158: 127-37 PubMed GONUTS page
- ↑ Kunda P et al. (2008) Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis. Curr Biol 18: 91-101 PubMed GONUTS page
- ↑ Ng J & Luo L (2004) Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron 44: 779-93 PubMed GONUTS page
- ↑ Simões Sde M et al. (2010) Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation. Dev Cell 19: 377-88 PubMed GONUTS page
