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FB:robo
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | robo ( synonyms: BEST:GM07780, CG13521, CT32892, D-Robo1, ROBO, Robo, Robo-1, Robo1, Roundabout, Roundabout 1, dRobo, dRobo1, robo1 ) | |
| Protein Name(s) | roundabout, | |
| External Links | ||
| FB | FBgn0005631 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001964 |
startle response |
FB:FBrf0205756 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0003151 |
outflow tract morphogenesis |
FB:FBrf0204371 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0002543 |
P |
From FB |
||
| GO:0004872 |
receptor activity |
FB:FBrf0160886 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0200053 |
IPI: Inferred from Physical Interaction |
FB:FBgn0003425 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0205517 |
IPI: Inferred from Physical Interaction |
FB:FBgn0003425 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0209122 |
IPI: Inferred from Physical Interaction |
FB:FBgn0034540 |
F |
From FB |
||
| GO:0005886 |
plasma membrane |
FB:FBrf0100585 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005886 |
plasma membrane |
FB:FBrf0151451 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005887 |
integral to plasma membrane |
FB:FBrf0100585 |
ISS: Inferred from Sequence or Structural Similarity |
EMBL:AF040990 |
C |
From FB |
||
| GO:0007411 |
axon guidance |
FB:FBrf0059166 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0107807 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0141528 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0149077 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0155635 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0159246 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0174512 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0200520 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007427 |
epithelial cell migration, open tracheal system |
FB:FBrf0167264 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007432 |
salivary gland boundary specification |
FB:FBrf0187388 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008038 |
neuron recognition |
FB:FBrf0156020 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008045 |
motor axon guidance |
FB:FBrf0211648 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008201 |
heparin binding |
FB:FBrf0200053 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0008201 |
heparin binding |
FB:FBrf0205517 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0008406 |
gonad development |
FB:FBrf0213539 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009649 |
entrainment of circadian clock |
FB:FBrf0202846 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0016199 |
axon midline choice point recognition |
FB:FBrf0108154 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016199 |
axon midline choice point recognition |
FB:FBrf0149078 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016199 |
axon midline choice point recognition |
FB:FBrf0191925 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016199 |
axon midline choice point recognition |
FB:FBrf0193348 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0022409 |
positive regulation of cell-cell adhesion |
FB:FBrf0194038 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030424 |
axon |
FB:FBrf0159246 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0030425 |
dendrite |
FB:FBrf0159246 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0031982 |
vesicle |
FB:FBrf0151451 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0031987 |
locomotion involved in locomotory behavior |
FB:FBrf0205756 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035050 |
embryonic heart tube development |
FB:FBrf0190040 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035050 |
embryonic heart tube development |
FB:FBrf0194038 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035385 |
Roundabout signaling pathway |
FB:FBrf0107807 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0003425 |
P |
From FB |
||
| GO:0043025 |
neuronal cell body |
FB:FBrf0159246 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0043234 |
protein complex |
FB:FBrf0209122 |
IPI: Inferred from Physical Interaction |
FB:FBgn0034540 |
C |
From FB |
||
| GO:0044295 |
axonal growth cone |
FB:FBrf0107807 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0159339 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0174512 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0207099 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048813 |
dendrite morphogenesis |
FB:FBrf0208790 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048854 |
brain morphogenesis |
FB:FBrf0205756 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0011259 |
P |
From FB |
||
| GO:0070983 |
dendrite guidance |
FB:FBrf0159246 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0071666 |
Slit-Robo signaling complex |
FB:FBrf0200053 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:2000274 |
regulation of epithelial cell migration, open tracheal system |
FB:FBrf0151931 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Yamamoto A et al. (2008) Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Proc Natl Acad Sci U S A 105: 12393-8 PubMed GONUTS page
- ↑ Zmojdzian M et al. (2008) Cellular components and signals required for the cardiac outflow tract assembly in Drosophila. Proc Natl Acad Sci U S A 105: 2475-80 PubMed GONUTS page
- ↑ Ribeiro C et al. (2003) Signaling systems, guided cell migration, and organogenesis: insights from genetic studies in Drosophila. Dev Biol 260: 1-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Hussain SA et al. (2006) A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. J Biol Chem 281: 39693-8 PubMed GONUTS page
- ↑ 5.0 5.1 Fukuhara N et al. (2008) Structural and functional analysis of slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo. J Biol Chem 283: 16226-34 PubMed GONUTS page
- ↑ 6.0 6.1 Wayburn B & Volk T (2009) LRT, a tendon-specific leucine-rich repeat protein, promotes muscle-tendon targeting through its interaction with Robo. Development 136: 3607-15 PubMed GONUTS page
- ↑ 7.0 7.1 Kidd T et al. (1998) Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell 92: 205-15 PubMed GONUTS page
- ↑ 8.0 8.1 Myat A et al. (2002) Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor. Neuron 35: 447-59 PubMed GONUTS page
- ↑ Seeger M et al. (1993) Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10: 409-26 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Kidd T et al. (1999) Slit is the midline repellent for the robo receptor in Drosophila. Cell 96: 785-94 PubMed GONUTS page
- ↑ Narayanan R & Ramaswami M (2001) Endocytosis in Drosophila: progress, possibilities, prognostications. Exp Cell Res 271: 28-35 PubMed GONUTS page
- ↑ Stevens A & Jacobs JR (2002) Integrins regulate responsiveness to slit repellent signals. J Neurosci 22: 4448-55 PubMed GONUTS page
- ↑ Patel BN & Van Vactor DL (2002) Axon guidance: the cytoplasmic tail. Curr Opin Cell Biol 14: 221-9 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 Furrer MP et al. (2003) Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline. Nat Neurosci 6: 223-30 PubMed GONUTS page
- ↑ 15.0 15.1 Grueber WB & Jan YN (2004) Dendritic development: lessons from Drosophila and related branches. Curr Opin Neurobiol 14: 74-82 PubMed GONUTS page
- ↑ Garbe DS et al. (2007) Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline. Development 134: 4325-34 PubMed GONUTS page
- ↑ Ghabrial A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol 19: 623-47 PubMed GONUTS page
- ↑ Kolesnikov T & Beckendorf SK (2005) NETRIN and SLIT guide salivary gland migration. Dev Biol 284: 102-11 PubMed GONUTS page
- ↑ Zlatic M et al. (2003) Genetic specification of axonal arbors: atonal regulates robo3 to position terminal branches in the Drosophila nervous system. Neuron 37: 41-51 PubMed GONUTS page
- ↑ Wright AP et al. (2010) Systematic screening of Drosophila deficiency mutations for embryonic phenotypes and orphan receptor ligands. PLoS One 5: e12288 PubMed GONUTS page
- ↑ Weyers JJ et al. (2011) A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. Dev Biol 353: 217-28 PubMed GONUTS page
- ↑ Berni J et al. (2008) The axon-guidance roundabout gene alters the pace of the Drosophila circadian clock. Eur J Neurosci 27: 396-407 PubMed GONUTS page
- ↑ Chiba A (1999) Early development of the Drosophila neuromuscular junction: a model for studying neuronal networks in development. Int Rev Neurobiol 43: 1-24 PubMed GONUTS page
- ↑ Ratnaparkhi A et al. (2002) Altered levels of Gq activity modulate axonal pathfinding in Drosophila. J Neurosci 22: 4499-508 PubMed GONUTS page
- ↑ Garbe DS et al. (2007) beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS. Development 134: 273-84 PubMed GONUTS page
- ↑ Simionato E et al. (2007) The Drosophila RNA-binding protein ELAV is required for commissural axon midline crossing via control of commissureless mRNA expression in neurons. Dev Biol 301: 166-77 PubMed GONUTS page
- ↑ 27.0 27.1 Santiago-Martínez E et al. (2006) Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration. Proc Natl Acad Sci U S A 103: 12441-6 PubMed GONUTS page
- ↑ Qian L et al. (2005) Slit and Robo control cardiac cell polarity and morphogenesis. Curr Biol 15: 2271-8 PubMed GONUTS page
- ↑ Gao FB & Bogert BA (2003) Genetic control of dendritic morphogenesis in Drosophila. Trends Neurosci 26: 262-8 PubMed GONUTS page
- ↑ Dimitrova S et al. (2008) Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila. Dev Biol 324: 18-30 PubMed GONUTS page
- ↑ Mauss A et al. (2009) Midline signalling systems direct the formation of a neural map by dendritic targeting in the Drosophila motor system. PLoS Biol 7: e1000200 PubMed GONUTS page
- ↑ Englund C et al. (2002) Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea. Development 129: 4941-51 PubMed GONUTS page