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FB:robo

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) robo ( synonyms: BEST:GM07780, CG13521, CT32892, D-Robo1, ROBO, Robo, Robo-1, Robo1, Roundabout, Roundabout 1, dRobo, dRobo1, robo1 )
Protein Name(s) roundabout,
External Links
FB FBgn0005631

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001964

startle response

FB:FBrf0205756
PMID:18713854[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0003151

outflow tract morphogenesis

FB:FBrf0204371
PMID:18250318[2]

IGI: Inferred from Genetic Interaction

FB:FBgn0002543

P

From FB

GO:0004872

receptor activity

FB:FBrf0160886
PMID:12885551[3]

TAS: Traceable Author Statement

F

From FB

GO:0005515

protein binding

FB:FBrf0200053
PMID:17062560[4]

IPI: Inferred from Physical Interaction

FB:FBgn0003425

F

From FB

GO:0005515

protein binding

FB:FBrf0205517
PMID:18359766[5]

IPI: Inferred from Physical Interaction

FB:FBgn0003425

F

From FB

GO:0005515

protein binding

FB:FBrf0209122
PMID:19793885[6]

IPI: Inferred from Physical Interaction

FB:FBgn0034540

F

From FB

GO:0005886

plasma membrane

FB:FBrf0100585
PMID:9458045[7]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0151451
PMID:12165468[8]

IDA: Inferred from Direct Assay

C

From FB

GO:0005887

integral to plasma membrane

FB:FBrf0100585
PMID:9458045[7]

ISS: Inferred from Sequence or Structural Similarity

EMBL:AF040990

C

From FB

GO:0007411

axon guidance

FB:FBrf0059166
PMID:8461134[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0107807
PMID:10102267[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0141528
PMID:11697879[11]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0149077
PMID:12040052[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0155635
PMID:11891122[13]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0159246
PMID:12592406[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0174512
PMID:15018941[15]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0200520
PMID:18003737[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0167264
PMID:14570584[17]

TAS: Traceable Author Statement

P

From FB

GO:0007432

salivary gland boundary specification

FB:FBrf0187388
PMID:15950216[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008038

neuron recognition

FB:FBrf0156020
PMID:12526771[19]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008045

motor axon guidance

FB:FBrf0211648
PMID:20808815[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008201

heparin binding

FB:FBrf0200053
PMID:17062560[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0008201

heparin binding

FB:FBrf0205517
PMID:18359766[5]

IDA: Inferred from Direct Assay

F

From FB

GO:0008406

gonad development

FB:FBrf0213539
PMID:21377458[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009649

entrainment of circadian clock

FB:FBrf0202846
PMID:18215236[22]

IDA: Inferred from Direct Assay

P

From FB

GO:0016199

axon midline choice point recognition

FB:FBrf0108154
PMID:10218152[23]

TAS: Traceable Author Statement

P

From FB

GO:0016199

axon midline choice point recognition

FB:FBrf0149078
PMID:12040057[24]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016199

axon midline choice point recognition

FB:FBrf0191925
PMID:17121810[25]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016199

axon midline choice point recognition

FB:FBrf0193348
PMID:17049509[26]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0022409

positive regulation of cell-cell adhesion

FB:FBrf0194038
PMID:16888037[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030424

axon

FB:FBrf0159246
PMID:12592406[14]

IDA: Inferred from Direct Assay

C

From FB

GO:0030425

dendrite

FB:FBrf0159246
PMID:12592406[14]

IDA: Inferred from Direct Assay

C

From FB

GO:0031982

vesicle

FB:FBrf0151451
PMID:12165468[8]

IDA: Inferred from Direct Assay

C

From FB

GO:0031987

locomotion involved in locomotory behavior

FB:FBrf0205756
PMID:18713854[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035050

embryonic heart tube development

FB:FBrf0190040
PMID:16360689[28]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035050

embryonic heart tube development

FB:FBrf0194038
PMID:16888037[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035385

Roundabout signaling pathway

FB:FBrf0107807
PMID:10102267[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0003425

P

From FB

GO:0043025

neuronal cell body

FB:FBrf0159246
PMID:12592406[14]

IDA: Inferred from Direct Assay

C

From FB

GO:0043234

protein complex

FB:FBrf0209122
PMID:19793885[6]

IPI: Inferred from Physical Interaction

FB:FBgn0034540

C

From FB

GO:0044295

axonal growth cone

FB:FBrf0107807
PMID:10102267[10]

IDA: Inferred from Direct Assay

C

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0159339
PMID:12744843[29]

TAS: Traceable Author Statement

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0174512
PMID:15018941[15]

TAS: Traceable Author Statement

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0207099
PMID:18817767[30]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048813

dendrite morphogenesis

FB:FBrf0208790
PMID:19771146[31]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048854

brain morphogenesis

FB:FBrf0205756
PMID:18713854[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0011259

P

From FB

GO:0070983

dendrite guidance

FB:FBrf0159246
PMID:12592406[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0071666

Slit-Robo signaling complex

FB:FBrf0200053
PMID:17062560[4]

IDA: Inferred from Direct Assay

C

From FB

GO:2000274

regulation of epithelial cell migration, open tracheal system

FB:FBrf0151931
PMID:12397103[32]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Yamamoto A et al. (2008) Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Proc Natl Acad Sci U S A 105: 12393-8 PubMed GONUTS page
  2. Zmojdzian M et al. (2008) Cellular components and signals required for the cardiac outflow tract assembly in Drosophila. Proc Natl Acad Sci U S A 105: 2475-80 PubMed GONUTS page
  3. Ribeiro C et al. (2003) Signaling systems, guided cell migration, and organogenesis: insights from genetic studies in Drosophila. Dev Biol 260: 1-8 PubMed GONUTS page
  4. 4.0 4.1 4.2 Hussain SA et al. (2006) A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. J Biol Chem 281: 39693-8 PubMed GONUTS page
  5. 5.0 5.1 Fukuhara N et al. (2008) Structural and functional analysis of slit and heparin binding to immunoglobulin-like domains 1 and 2 of Drosophila Robo. J Biol Chem 283: 16226-34 PubMed GONUTS page
  6. 6.0 6.1 Wayburn B & Volk T (2009) LRT, a tendon-specific leucine-rich repeat protein, promotes muscle-tendon targeting through its interaction with Robo. Development 136: 3607-15 PubMed GONUTS page
  7. 7.0 7.1 Kidd T et al. (1998) Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell 92: 205-15 PubMed GONUTS page
  8. 8.0 8.1 Myat A et al. (2002) Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor. Neuron 35: 447-59 PubMed GONUTS page
  9. Seeger M et al. (1993) Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10: 409-26 PubMed GONUTS page
  10. 10.0 10.1 10.2 Kidd T et al. (1999) Slit is the midline repellent for the robo receptor in Drosophila. Cell 96: 785-94 PubMed GONUTS page
  11. Narayanan R & Ramaswami M (2001) Endocytosis in Drosophila: progress, possibilities, prognostications. Exp Cell Res 271: 28-35 PubMed GONUTS page
  12. Stevens A & Jacobs JR (2002) Integrins regulate responsiveness to slit repellent signals. J Neurosci 22: 4448-55 PubMed GONUTS page
  13. Patel BN & Van Vactor DL (2002) Axon guidance: the cytoplasmic tail. Curr Opin Cell Biol 14: 221-9 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 Furrer MP et al. (2003) Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline. Nat Neurosci 6: 223-30 PubMed GONUTS page
  15. 15.0 15.1 Grueber WB & Jan YN (2004) Dendritic development: lessons from Drosophila and related branches. Curr Opin Neurobiol 14: 74-82 PubMed GONUTS page
  16. Garbe DS et al. (2007) Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline. Development 134: 4325-34 PubMed GONUTS page
  17. Ghabrial A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol 19: 623-47 PubMed GONUTS page
  18. Kolesnikov T & Beckendorf SK (2005) NETRIN and SLIT guide salivary gland migration. Dev Biol 284: 102-11 PubMed GONUTS page
  19. Zlatic M et al. (2003) Genetic specification of axonal arbors: atonal regulates robo3 to position terminal branches in the Drosophila nervous system. Neuron 37: 41-51 PubMed GONUTS page
  20. Wright AP et al. (2010) Systematic screening of Drosophila deficiency mutations for embryonic phenotypes and orphan receptor ligands. PLoS One 5: e12288 PubMed GONUTS page
  21. Weyers JJ et al. (2011) A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. Dev Biol 353: 217-28 PubMed GONUTS page
  22. Berni J et al. (2008) The axon-guidance roundabout gene alters the pace of the Drosophila circadian clock. Eur J Neurosci 27: 396-407 PubMed GONUTS page
  23. Chiba A (1999) Early development of the Drosophila neuromuscular junction: a model for studying neuronal networks in development. Int Rev Neurobiol 43: 1-24 PubMed GONUTS page
  24. Ratnaparkhi A et al. (2002) Altered levels of Gq activity modulate axonal pathfinding in Drosophila. J Neurosci 22: 4499-508 PubMed GONUTS page
  25. Garbe DS et al. (2007) beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS. Development 134: 273-84 PubMed GONUTS page
  26. Simionato E et al. (2007) The Drosophila RNA-binding protein ELAV is required for commissural axon midline crossing via control of commissureless mRNA expression in neurons. Dev Biol 301: 166-77 PubMed GONUTS page
  27. 27.0 27.1 Santiago-Martínez E et al. (2006) Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration. Proc Natl Acad Sci U S A 103: 12441-6 PubMed GONUTS page
  28. Qian L et al. (2005) Slit and Robo control cardiac cell polarity and morphogenesis. Curr Biol 15: 2271-8 PubMed GONUTS page
  29. Gao FB & Bogert BA (2003) Genetic control of dendritic morphogenesis in Drosophila. Trends Neurosci 26: 262-8 PubMed GONUTS page
  30. Dimitrova S et al. (2008) Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila. Dev Biol 324: 18-30 PubMed GONUTS page
  31. Mauss A et al. (2009) Midline signalling systems direct the formation of a neural map by dendritic targeting in the Drosophila motor system. PLoS Biol 7: e1000200 PubMed GONUTS page
  32. Englund C et al. (2002) Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea. Development 129: 4941-51 PubMed GONUTS page
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