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FB:raps

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) raps ( synonyms: CG5692, PINS, Partner of Inscutable, Partner of Inscuteable, Pins, Rad, Raps, Rapsinoid, Rapsynoid, partner of inscuteable, pins, rad, rapsyn )
Protein Name(s) rapsynoid,
External Links
FB FBgn0040080

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000132

establishment of mitotic spindle orientation

FB:FBrf0155873
PMID:12571286[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0005515

protein binding

FB:FBrf0201141
PMID:17726110[2]

IPI: Inferred from Physical Interaction

FB:FBgn0001104

F

From FB

GO:0005515

protein binding

FB:FBrf0201141
PMID:17726110[2]

IPI: Inferred from Physical Interaction

FB:FBgn0002873

F

From FB

GO:0005938

cell cortex

FB:FBrf0174511
PMID:15018932[3]

TAS: Traceable Author Statement

C

From FB

GO:0007165

signal transduction

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR003109

P

From FB

GO:0007400

neuroblast fate determination

FB:FBrf0128431
PMID:10887088[4]

TAS: Traceable Author Statement

P

From FB

GO:0007405

neuroblast proliferation

FB:FBrf0188152
PMID:16142234[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008105

asymmetric protein localization

FB:FBrf0128431
PMID:10887088[4]

TAS: Traceable Author Statement

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0125655

NAS: Non-traceable Author Statement

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0128431
PMID:10887088[4]

TAS: Traceable Author Statement

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0128604

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0155873
PMID:12571286[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0210175
PMID:20194641[6]

IDA: Inferred from Direct Assay

P

From FB

GO:0030695

GTPase regulator activity

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR003109

F

From FB

GO:0040001

establishment of mitotic spindle localization

FB:FBrf0128431
PMID:10887088[4]

TAS: Traceable Author Statement

P

From FB

GO:0040001

establishment of mitotic spindle localization

FB:FBrf0156078
PMID:12185850[7]

TAS: Traceable Author Statement

P

From FB

GO:0045167

asymmetric protein localization involved in cell fate determination

FB:FBrf0156078
PMID:12185850[7]

TAS: Traceable Author Statement

P

From FB

GO:0045175

basal protein localization

FB:FBrf0132418
PMID:11117748[8]

TAS: Traceable Author Statement

P

From FB

GO:0045177

apical part of cell

FB:FBrf0132418
PMID:11117748[8]

NAS: Non-traceable Author Statement

C

From FB

GO:0045179

apical cortex

FB:FBrf0132417
PMID:11117747[9]

TAS: Traceable Author Statement

C

From FB

GO:0045179

apical cortex

FB:FBrf0156163
PMID:11697883[10]

TAS: Traceable Author Statement

C

From FB

GO:0045179

apical cortex

FB:FBrf0187602
PMID:15937221[11]

IDA: Inferred from Direct Assay

C

From FB

GO:0045179

apical cortex

FB:FBrf0189924
PMID:16377571[12]

IDA: Inferred from Direct Assay

C

From FB

GO:0045179

apical cortex

FB:FBrf0201141
PMID:17726110[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0045185

maintenance of protein location

FB:FBrf0156163
PMID:11697883[10]

NAS: Non-traceable Author Statement

P

From FB

GO:0051294

establishment of spindle orientation

FB:FBrf0189924
PMID:16377571[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0055059

asymmetric neuroblast division

FB:FBrf0155600
PMID:12526793[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0055059

asymmetric neuroblast division

FB:FBrf0201104
PMID:17507418[14]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Yu F et al. (2003) A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts. J Cell Sci 116: 887-96 PubMed GONUTS page
  2. 2.0 2.1 2.2 Nipper RW et al. (2007) Galphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts. Proc Natl Acad Sci U S A 104: 14306-11 PubMed GONUTS page
  3. Bardin AJ et al. (2004) Asymmetric localization and function of cell-fate determinants: a fly's view. Curr Opin Neurobiol 14: 6-14 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Cheah PY et al. (2000) Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates. Development 127: 3325-35 PubMed GONUTS page
  5. Caussinus E & Gonzalez C (2005) Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet 37: 1125-9 PubMed GONUTS page
  6. Januschke J & Gonzalez C (2010) The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts. J Cell Biol 188: 693-706 PubMed GONUTS page
  7. 7.0 7.1 Gönczy P (2002) Mechanisms of spindle positioning: focus on flies and worms. Trends Cell Biol 12: 332-9 PubMed GONUTS page
  8. 8.0 8.1 Peng CY et al. (2000) The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 408: 596-600 PubMed GONUTS page
  9. Ohshiro T et al. (2000) Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408: 593-6 PubMed GONUTS page
  10. 10.0 10.1 Schaefer M & Knoblich JA (2001) Protein localization during asymmetric cell division. Exp Cell Res 271: 66-74 PubMed GONUTS page
  11. Yu F et al. (2005) Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions. Genes Dev 19: 1341-53 PubMed GONUTS page
  12. 12.0 12.1 Siegrist SE & Doe CQ (2005) Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts. Cell 123: 1323-35 PubMed GONUTS page
  13. Cai Y et al. (2003) Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions. Cell 112: 51-62 PubMed GONUTS page
  14. Bonaccorsi S et al. (2007) The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division. Development 134: 2183-93 PubMed GONUTS page
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