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FB:r2d2
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | r2d2 ( synonyms: CG7138, R2D2, R2d2, cg7138 ) | |
| Protein Name(s) | r2d2, | |
| External Links | ||
| FB | FBgn0031951 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003725 |
double-stranded RNA binding |
FB:FBrf0129923 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0003725 |
double-stranded RNA binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0205524 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0205524 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016442 |
RNA-induced silencing complex |
FB:FBrf0208622 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0030422 |
production of siRNA involved in RNA interference |
FB:FBrf0209625 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0030713 |
ovarian follicle cell stalk formation |
FB:FBrf0205524 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035087 |
siRNA loading onto RISC involved in RNA interference |
FB:FBrf0162291 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0035087 |
siRNA loading onto RISC involved in RNA interference |
FB:FBrf0179908 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0051607 |
defense response to virus |
FB:FBrf0190618 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051607 |
defense response to virus |
FB:FBrf0212288 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0070868 |
heterochromatin organization involved in chromatin silencing |
FB:FBrf0209635 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0070918 |
production of small RNA involved in gene silencing by RNA |
FB:FBrf0209625 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0070920 |
regulation of production of small RNA involved in gene silencing by RNA |
FB:FBrf0213543 |
IDA: Inferred from Direct Assay |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Lasko P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J Cell Biol 150: F51-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kalidas S et al. (2008) Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1. Mech Dev 125: 475-85 PubMed GONUTS page
- ↑ Liu Y et al. (2009) C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 325: 750-3 PubMed GONUTS page
- ↑ 4.0 4.1 Marques JT et al. (2010) Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila. Nat Struct Mol Biol 17: 24-30 PubMed GONUTS page
- ↑ Liu Q et al. (2003) R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science 301: 1921-5 PubMed GONUTS page
- ↑ Murchison EP & Hannon GJ (2004) miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol 16: 223-9 PubMed GONUTS page
- ↑ Wang XH et al. (2006) RNA interference directs innate immunity against viruses in adult Drosophila. Science 312: 452-4 PubMed GONUTS page
- ↑ Mueller S et al. (2010) RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila. Proc Natl Acad Sci U S A 107: 19390-5 PubMed GONUTS page
- ↑ Fagegaltier D et al. (2009) The endogenous siRNA pathway is involved in heterochromatin formation in Drosophila. Proc Natl Acad Sci U S A 106: 21258-63 PubMed GONUTS page
- ↑ Cenik ES et al. (2011) Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease. Mol Cell 42: 172-84 PubMed GONUTS page
