GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:polo
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | polo ( synonyms: 0256/04, 1324/08, CG12306, POLO, POLO/PLK1, Polo, Polo kinase, Polo protein kinase, anon-WO0172774.3, l(3)01673, l(3)77Aa, l(3)S025604, l(3)S132408 ) | |
| Protein Name(s) | polo, | |
| External Links | ||
| FB | FBgn0003124 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000278 |
mitotic cell cycle |
FB:FBrf0206217 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0002645 |
P |
From FB |
||
| GO:0000278 |
mitotic cell cycle |
FB:FBrf0206217 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0000776 |
kinetochore |
FB:FBrf0180221 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0000776 |
kinetochore |
FB:FBrf0206217 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0000910 |
cytokinesis |
FB:FBrf0106047 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0000922 |
spindle pole |
FB:FBrf0180221 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0000940 |
condensed chromosome outer kinetochore |
FB:FBrf0137330 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0000940 |
condensed chromosome outer kinetochore |
FB:FBrf0208144 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0004672 |
protein kinase activity |
FB:FBrf0059150 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004672 |
protein kinase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0054049 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0090826 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0156857 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005635 |
nuclear envelope |
FB:FBrf0206217 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0156857 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0208144 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005813 |
centrosome |
FB:FBrf0106645 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005813 |
centrosome |
FB:FBrf0206217 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005819 |
spindle |
FB:FBrf0106645 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005819 |
spindle |
FB:FBrf0206217 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005874 |
microtubule |
FB:FBrf0206217 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0006911 |
phagocytosis, engulfment |
FB:FBrf0191376 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007049 |
cell cycle |
FB:FBrf0167741 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007052 |
mitotic spindle organization |
FB:FBrf0200397 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007058 |
spindle assembly involved in female meiosis II |
FB:FBrf0130043 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007060 |
male meiosis chromosome segregation |
FB:FBrf0106047 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007067 |
mitosis |
FB:FBrf0048435 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007067 |
mitosis |
FB:FBrf0156857 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007067 |
mitosis |
FB:FBrf0207149 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007140 |
male meiosis |
FB:FBrf0048435 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007143 |
female meiosis |
FB:FBrf0192446 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007147 |
female meiosis II |
FB:FBrf0130043 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007344 |
pronuclear fusion |
FB:FBrf0130043 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007406 |
negative regulation of neuroblast proliferation |
FB:FBrf0202130 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008104 |
protein localization |
FB:FBrf0134594 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0022008 |
neurogenesis |
FB:FBrf0214431 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030496 |
midbody |
FB:FBrf0208144 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0035044 |
sperm aster formation |
FB:FBrf0130043 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035046 |
pronuclear migration |
FB:FBrf0130043 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Archambault V et al. (2008) Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis. Genes Dev 22: 2707-20 PubMed GONUTS page
- ↑ 2.0 2.1 Prigent C et al. (2005) Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure. Exp Cell Res 303: 1-13 PubMed GONUTS page
- ↑ 3.0 3.1 Glover DM et al. (1998) Polo-like kinases: a team that plays throughout mitosis. Genes Dev 12: 3777-87 PubMed GONUTS page
- ↑ Blower MD & Karpen GH (2001) The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions. Nat Cell Biol 3: 730-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Nie M et al. (2009) Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation. PLoS One 4: e5905 PubMed GONUTS page
- ↑ Fenton B & Glover DM (1993) A conserved mitotic kinase active at late anaphase-telophase in syncytial Drosophila embryos. Nature 363: 637-40 PubMed GONUTS page
- ↑ 7.0 7.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ Llamazares S et al. (1991) polo encodes a protein kinase homolog required for mitosis in Drosophila. Genes Dev 5: 2153-65 PubMed GONUTS page
- ↑ Tavares AA et al. (1996) The conserved mitotic kinase polo is regulated by phosphorylation and has preferred microtubule-associated substrates in Drosophila embryo extracts. EMBO J 15: 4873-83 PubMed GONUTS page
- ↑ 10.0 10.1 Herrmann S et al. (1998) The POLO kinase is required at multiple stages during spermatogenesis in Drosophila melanogaster. Chromosoma 107: 440-51 PubMed GONUTS page
- ↑ Stroschein-Stevenson SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol 4: e4 PubMed GONUTS page
- ↑ Kiger AA et al. (2003) A functional genomic analysis of cell morphology using RNA interference. J Biol 2: 27 PubMed GONUTS page
- ↑ Goshima G et al. (2007) Genes required for mitotic spindle assembly in Drosophila S2 cells. Science 316: 417-21 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 Riparbelli MG et al. (2000) Failure of pronuclear migration and repeated divisions of polar body nuclei associated with MTOC defects in polo eggs of Drosophila. J Cell Sci 113 ( Pt 18): 3341-50 PubMed GONUTS page
- ↑ 15.0 15.1 Sunkel CE & Glover DM (1988) polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J Cell Sci 89 ( Pt 1): 25-38 PubMed GONUTS page
- ↑ Ducat D et al. (2008) Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin. Mol Biol Cell 19: 3097-110 PubMed GONUTS page
- ↑ Mirouse V et al. (2006) Interaction between Polo and BicD proteins links oocyte determination and meiosis control in Drosophila. Development 133: 4005-13 PubMed GONUTS page
- ↑ Wang H et al. (2007) Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon. Nature 449: 96-100 PubMed GONUTS page
- ↑ Gonzalez C & Bornens M (2000) Light, flies and cell division. Workshop: regulation of cell division in Drosophila. EMBO Rep 1: 390-3 PubMed GONUTS page
