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FB:pnt

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) pnt ( synonyms: 0123/09, 0608/07, 0998/12, 3520, CG17077, D-Ets-2, D-ets-2, DMPOINT1A, E(E2F)3D, EK3-2, ETS2, EY3-1, Ets at 58AB, Ets protein Pointed P2, Ets2, Ets58AB, Ets94F, PNT-P1, PNTP1, PNTP2, POINT, Pnt, Pnt-P1, PntP1, PntP2, Pointed, Pointed-P1, Pointed2, PointedP2, ets94F, l(3)07825, l(3)j1B7, l(3)s118306, png, pnt-P1, pnt-P2, pntP2, pointed P2, pointed-P1, pointed-P2, pointed-RC, pointedP2, ptd )
Protein Name(s) pointed,
External Links
FB FBgn0003118

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000981

sequence-specific DNA binding RNA polymerase II transcription factor activity

FB:FBrf0161068
PMID:12874129[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:95455

F

From FB

GO:0005515

protein binding

FB:FBrf0135901
PMID:11357138[2]

IPI: Inferred from Physical Interaction

FB:FBgn0023214

F

From FB

GO:0005634

nucleus

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:95455

C

From FB

GO:0005634

nucleus

FB:FBrf0156682

NAS: Non-traceable Author Statement

C

From FB

GO:0006355

regulation of transcription, DNA-dependent

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:95455

P

From FB

GO:0006911

phagocytosis, engulfment

FB:FBrf0191376
PMID:16336044[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006916

anti-apoptosis

FB:FBrf0105264
PMID:9814703[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0003997

P

From FB

GO:0007157

heterophilic cell-cell adhesion

FB:FBrf0156682

NAS: Non-traceable Author Statement

P

From FB

GO:0007173

epidermal growth factor receptor signaling pathway

FB:FBrf0131266
PMID:11105896[5]

NAS: Non-traceable Author Statement

P

From FB

GO:0007265

Ras protein signal transduction

FB:FBrf0129916
PMID:10929403[6]

TAS: Traceable Author Statement

P

From FB

GO:0007362

terminal region determination

FB:FBrf0054989
PMID:1905816[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0003733

P

From FB

GO:0007422

peripheral nervous system development

FB:FBrf0083410
PMID:8060613[8]

TAS: Traceable Author Statement

P

From FB

GO:0007424

open tracheal system development

FB:FBrf0125237
PMID:10684581[9]

NAS: Non-traceable Author Statement

P

From FB

GO:0007426

tracheal outgrowth, open tracheal system

FB:FBrf0190195
PMID:16326394[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007427

epithelial cell migration, open tracheal system

FB:FBrf0211250
PMID:20516215[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007428

primary branching, open tracheal system

FB:FBrf0187390
PMID:15848387[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007429

secondary branching, open tracheal system

FB:FBrf0148947
PMID:12015974[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007429

secondary branching, open tracheal system

FB:FBrf0167264
PMID:14570584[14]

TAS: Traceable Author Statement

P

From FB

GO:0007455

eye-antennal disc morphogenesis

FB:FBrf0192868
PMID:16963016[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007464

R3/R4 cell fate commitment

FB:FBrf0204109
PMID:18291359[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007476

imaginal disc-derived wing morphogenesis

FB:FBrf0193945
PMID:16648592[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007507

heart development

FB:FBrf0151249
PMID:12027431[18]

NAS: Non-traceable Author Statement

P

From FB

GO:0007507

heart development

FB:FBrf0160748
PMID:12837580[19]

TAS: Traceable Author Statement

P

From FB

GO:0008284

positive regulation of cell proliferation

FB:FBrf0212840
PMID:21176204[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008293

torso signaling pathway

FB:FBrf0054989
PMID:1905816[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0003733

P

From FB

GO:0009997

negative regulation of cardioblast cell fate specification

FB:FBrf0160371
PMID:12756183[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030707

ovarian follicle cell development

FB:FBrf0128450
PMID:10822261[22]

TAS: Traceable Author Statement

P

From FB

GO:0035225

determination of genital disc primordium

FB:FBrf0187379
PMID:15893978[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000418
InterPro:IPR003118

F

From FB

GO:0045467

R7 cell development

FB:FBrf0129916
PMID:10929403[6]

TAS: Traceable Author Statement

P

From FB

GO:0045610

regulation of hemocyte differentiation

FB:FBrf0180639
PMID:15381778[24]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0147141
PMID:12175485[25]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0161068
PMID:12874129[1]

IDA: Inferred from Direct Assay

P

From FB

GO:0048190

wing disc dorsal/ventral pattern formation

FB:FBrf0202749
PMID:18202376[26]

IGI: Inferred from Genetic Interaction

FB:FBgn0000242
FB:FBgn0000099

P

From FB

GO:0048747

muscle fiber development

FB:FBrf0191368
PMID:16207075[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0061320

pericardial nephrocyte differentiation

FB:FBrf0160371
PMID:12756183[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0061331

epithelial cell proliferation involved in Malpighian tubule morphogenesis

FB:FBrf0102951
PMID:9637680[28]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0070491

repressing transcription factor binding

FB:FBrf0161068
PMID:12874129[1]

IPI: Inferred from Physical Interaction

FB:FBgn0023214

F

From FB

contributes_to

GO:0001077

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

FB:FBrf0158889
PMID:12702656[29]

IDA: Inferred from Direct Assay

F

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Yamada T et al. (2003) EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed. Development 130: 4085-96 PubMed GONUTS page
  2. Baker DA et al. (2001) Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila. Nature 411: 330-4 PubMed GONUTS page
  3. Stroschein-Stevenson SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol 4: e4 PubMed GONUTS page
  4. Kurada P & White K (1998) Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95: 319-29 PubMed GONUTS page
  5. Canon J & Banerjee U (2000) Runt and Lozenge function in Drosophila development. Semin Cell Dev Biol 11: 327-36 PubMed GONUTS page
  6. 6.0 6.1 Kumar JP & Moses K (2000) Cell fate specification in the Drosophila retina. Results Probl Cell Differ 31: 93-114 PubMed GONUTS page
  7. 7.0 7.1 Strecker TR et al. (1991) Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo. Proc Natl Acad Sci U S A 88: 5824-8 PubMed GONUTS page
  8. Salzberg A et al. (1994) Mutations affecting the pattern of the PNS in Drosophila reveal novel aspects of neuronal development. Neuron 13: 269-87 PubMed GONUTS page
  9. Zelzer E & Shilo BZ (2000) Cell fate choices in Drosophila tracheal morphogenesis. Bioessays 22: 219-26 PubMed GONUTS page
  10. Cabernard C & Affolter M (2005) Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Dev Cell 9: 831-42 PubMed GONUTS page
  11. Hsouna A et al. (2010) Drosophila von Hippel-Lindau tumor suppressor gene function in epithelial tubule morphogenesis. Mol Cell Biol 30: 3779-94 PubMed GONUTS page
  12. Myat MM et al. (2005) A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila trachea. Dev Biol 281: 38-52 PubMed GONUTS page
  13. Ribeiro C et al. (2002) In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev Cell 2: 677-83 PubMed GONUTS page
  14. Ghabrial A et al. (2003) Branching morphogenesis of the Drosophila tracheal system. Annu Rev Cell Dev Biol 19: 623-47 PubMed GONUTS page
  15. Brown KE et al. (2006) Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway. Dev Biol 300: 710-21 PubMed GONUTS page
  16. Weber U et al. (2008) Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye. Dev Biol 316: 110-23 PubMed GONUTS page
  17. Dworkin I & Gibson G (2006) Epidermal growth factor receptor and transforming growth factor-beta signaling contributes to variation for wing shape in Drosophila melanogaster. Genetics 173: 1417-31 PubMed GONUTS page
  18. Cripps RM & Olson EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 246: 14-28 PubMed GONUTS page
  19. Lo PC & Frasch M (2003) Establishing A-P polarity in the embryonic heart tube: a conserved function of Hox genes in Drosophila and vertebrates? Trends Cardiovasc Med 13: 182-7 PubMed GONUTS page
  20. Buchon N et al. (2010) Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol 8: 152 PubMed GONUTS page
  21. 21.0 21.1 Alvarez AD et al. (2003) pannier and pointedP2 act sequentially to regulate Drosophila heart development. Development 130: 3015-26 PubMed GONUTS page
  22. Dobens LL & Raftery LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev Dyn 218: 80-93 PubMed GONUTS page
  23. Chen EH et al. (2005) Allocation and specification of the genital disc precursor cells in Drosophila. Dev Biol 281: 270-85 PubMed GONUTS page
  24. Zettervall CJ et al. (2004) A directed screen for genes involved in Drosophila blood cell activation. Proc Natl Acad Sci U S A 101: 14192-7 PubMed GONUTS page
  25. Ohshiro T et al. (2002) Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea. Mech Dev 114: 3-11 PubMed GONUTS page
  26. Bejarano F et al. (2008) A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing. Genetics 178: 307-23 PubMed GONUTS page
  27. Dutta D et al. (2005) Drosophila Heartless acts with Heartbroken/Dof in muscle founder differentiation. PLoS Biol 3: e337 PubMed GONUTS page
  28. Kerber B et al. (1998) Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney. Genes Dev 12: 1781-6 PubMed GONUTS page
  29. Yuasa Y et al. (2003) Drosophila homeodomain protein REPO controls glial differentiation by cooperating with ETS and BTB transcription factors. Development 130: 2419-28 PubMed GONUTS page
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