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FB:ple

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) ple ( synonyms: CG10118, DH65B, DTH, Drosophila tyrosine hydroxylase, Pale, TH, Th, Tyrosine Hydroxylase, Tyrosine hydroxylase, Tyrosine-3-hydroxylase, VII, XBB70 Group VII, dTH1, dTH65B, pale/ple, tyrosine hydrodroxylase, tyrosine hydroxylase, tyrosine-hydroxylase )
Protein Name(s) pale,
External Links
FB FBgn0005626

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004511

tyrosine 3-monooxygenase activity

FB:FBrf0050671
PMID:2483109[1]

NAS: Non-traceable Author Statement

F

From FB

GO:0004511

tyrosine 3-monooxygenase activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:98735

F

From FB

GO:0004511

tyrosine 3-monooxygenase activity

FB:FBrf0123684

NAS: Non-traceable Author Statement

F

From FB

GO:0004511

tyrosine 3-monooxygenase activity

FB:FBrf0162298
PMID:12957543[2]

TAS: Traceable Author Statement

F

From FB

GO:0005506

iron ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001273
InterPro:IPR018301

F

From FB

GO:0005575

cellular component

FB:FBrf0159398

ND: No biological Data available

C

From FB

GO:0006584

catecholamine metabolic process

FB:FBrf0050671
PMID:2483109[1]

NAS: Non-traceable Author Statement

P

From FB

GO:0006584

catecholamine metabolic process

FB:FBrf0123684

NAS: Non-traceable Author Statement

P

From FB

GO:0007619

courtship behavior

FB:FBrf0146868
PMID:12000098[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0008049

male courtship behavior

FB:FBrf0206673
PMID:19238209[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008344

adult locomotory behavior

FB:FBrf0148899
PMID:12036114[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0009072

aromatic amino acid family metabolic process

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001273
InterPro:IPR018301

P

From FB

GO:0035220

wing disc development

FB:FBrf0215569
PMID:21808060[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0040040

thermosensory behavior

FB:FBrf0213392
PMID:21455291[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042053

regulation of dopamine metabolic process

FB:FBrf0145739

NAS: Non-traceable Author Statement

P

From FB

GO:0042416

dopamine biosynthetic process

FB:FBrf0206673
PMID:19238209[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042417

dopamine metabolic process

FB:FBrf0212779
PMID:21187381[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0043052

thermotaxis

FB:FBrf0213392
PMID:21455291[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048066

developmental pigmentation

FB:FBrf0162298
PMID:12957543[2]

TAS: Traceable Author Statement

P

From FB

GO:0048067

cuticle pigmentation

FB:FBrf0211574
PMID:20211259[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048082

regulation of adult chitin-containing cuticle pigmentation

FB:FBrf0215011
PMID:21878507[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0014006

P

From FB

GO:0048082

regulation of adult chitin-containing cuticle pigmentation

FB:FBrf0215011
PMID:21878507[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048085

adult chitin-containing cuticle pigmentation

FB:FBrf0215569
PMID:21808060[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0055114

oxidation-reduction process

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001273
InterPro:IPR005962
InterPro:IPR018301
InterPro:IPR019774

P

From FB

GO:2000274

regulation of epithelial cell migration, open tracheal system

FB:FBrf0200509
PMID:17585895[11]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Neckameyer WS & Quinn WG (1989) Isolation and characterization of the gene for Drosophila tyrosine hydroxylase. Neuron 2: 1167-75 PubMed GONUTS page
  2. 2.0 2.1 Wittkopp PJ et al. (2003) Evolution in black and white: genetic control of pigment patterns in Drosophila. Trends Genet 19: 495-504 PubMed GONUTS page
  3. Billeter JC et al. (2002) Genes mediating sex-specific behaviors in Drosophila. Adv Genet 47: 87-116 PubMed GONUTS page
  4. 4.0 4.1 Liu T et al. (2009) Reduction of dopamine level enhances the attractiveness of male Drosophila to other males. PLoS One 4: e4574 PubMed GONUTS page
  5. Pendleton RG et al. (2002) Effects of tyrosine hydroxylase mutants on locomotor activity in Drosophila: a study in functional genomics. Behav Genet 32: 89-94 PubMed GONUTS page
  6. 6.0 6.1 Anh NT et al. (2011) Essential role of Duox in stabilization of Drosophila wing. J Biol Chem 286: 33244-51 PubMed GONUTS page
  7. 7.0 7.1 Bang S et al. (2011) Dopamine signalling in mushroom bodies regulates temperature-preference behaviour in Drosophila. PLoS Genet 7: e1001346 PubMed GONUTS page
  8. Riemensperger T et al. (2011) Behavioral consequences of dopamine deficiency in the Drosophila central nervous system. Proc Natl Acad Sci U S A 108: 834-9 PubMed GONUTS page
  9. Bayersdorfer F et al. (2010) Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease. Neurobiol Dis 40: 113-9 PubMed GONUTS page
  10. 10.0 10.1 Sekine Y et al. (2011) p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. J Cell Sci 124: 3006-16 PubMed GONUTS page
  11. Hsouna A et al. (2007) Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis. Dev Biol 308: 30-43 PubMed GONUTS page
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