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FB:piwi
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | piwi ( synonyms: CG6122, P-element induced wimpy testis, PIWI, Piwi ) | |
| Protein Name(s) | piwi, | |
| External Links | ||
| FB | FBgn0004872 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000335 |
negative regulation of transposition, DNA-mediated |
FB:FBrf0188192 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0000791 |
euchromatin |
FB:FBrf0201020 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0001709 |
cell fate determination |
FB:FBrf0132360 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0003723 |
RNA binding |
FB:FBrf0200494 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0003729 |
mRNA binding |
FB:FBrf0157343 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0191897 |
IPI: Inferred from Physical Interaction |
FB:FBgn0028734 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0191897 |
IPI: Inferred from Physical Interaction |
FB:FBgn0039016 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0191897 |
IPI: Inferred from Physical Interaction |
FB:FBgn0262526 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0156099 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0189910 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0191820 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0200494 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005634 |
nucleus |
FB:FBrf0214783 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005654 |
nucleoplasm |
FB:FBrf0132360 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005654 |
nucleoplasm |
FB:FBrf0155987 |
TAS: Traceable Author Statement |
C |
From FB |
|||
| GO:0005654 |
nucleoplasm |
FB:FBrf0209029 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005700 |
polytene chromosome |
FB:FBrf0201020 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0157343 |
NAS: Non-traceable Author Statement |
C |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0214783 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006342 |
chromatin silencing |
FB:FBrf0145115 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006342 |
chromatin silencing |
FB:FBrf0168038 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006342 |
chromatin silencing |
FB:FBrf0189910 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007279 |
pole cell formation |
FB:FBrf0191897 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010369 |
chromocenter |
FB:FBrf0201020 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0016246 |
RNA interference |
FB:FBrf0156099 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0016441 |
posttranscriptional gene silencing |
FB:FBrf0145115 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0017145 |
stem cell division |
FB:FBrf0105800 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030718 |
germ-line stem cell maintenance |
FB:FBrf0149162 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0031933 |
telomeric heterochromatin |
FB:FBrf0201020 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0042078 |
germ-line stem cell division |
FB:FBrf0132360 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0042078 |
germ-line stem cell division |
FB:FBrf0155987 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0048132 |
female germ-line stem cell division |
FB:FBrf0105800 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048133 |
male germ-line stem cell division |
FB:FBrf0105800 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0060213 |
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
FB:FBrf0212183 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0070725 |
Yb body |
FB:FBrf0216344 |
IPI: Inferred from Physical Interaction |
FB:FBgn0041164 |
C |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kalmykova AI et al. (2005) Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline. Nucleic Acids Res 33: 2052-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Brower-Toland B et al. (2007) Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes Dev 21: 2300-11 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Deng W & Lin H (2001) Asymmetric germ cell division and oocyte determination during Drosophila oogenesis. Int Rev Cytol 203: 93-138 PubMed GONUTS page
- ↑ 4.0 4.1 Brennecke J et al. (2007) Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 128: 1089-103 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Megosh HB et al. (2006) The role of PIWI and the miRNA machinery in Drosophila germline determination. Curr Biol 16: 1884-94 PubMed GONUTS page
- ↑ 6.0 6.1 Cerutti H (2003) RNA interference: traveling in the cell and gaining functions? Trends Genet 19: 39-46 PubMed GONUTS page
- ↑ 7.0 7.1 Grimaud C et al. (2006) RNAi components are required for nuclear clustering of Polycomb group response elements. Cell 124: 957-71 PubMed GONUTS page
- ↑ Saito K et al. (2006) Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome. Genes Dev 20: 2214-22 PubMed GONUTS page
- ↑ 9.0 9.1 Zamparini AL et al. (2011) Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila. Development 138: 4039-50 PubMed GONUTS page
- ↑ 10.0 10.1 Lin H (2002) The stem-cell niche theory: lessons from flies. Nat Rev Genet 3: 931-40 PubMed GONUTS page
- ↑ Lau NC et al. (2009) Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Res 19: 1776-85 PubMed GONUTS page
- ↑ 12.0 12.1 Pal-Bhadra M et al. (2002) RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol Cell 9: 315-27 PubMed GONUTS page
- ↑ Pal-Bhadra M et al. (2004) Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303: 669-72 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Cox DN et al. (1998) A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. Genes Dev 12: 3715-27 PubMed GONUTS page
- ↑ Williams RW & Rubin GM (2002) ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos. Proc Natl Acad Sci U S A 99: 6889-94 PubMed GONUTS page
- ↑ Rouget C et al. (2010) Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature 467: 1128-32 PubMed GONUTS page
- ↑ Handler D et al. (2011) A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. EMBO J 30: 3977-93 PubMed GONUTS page
