FB:park

From GONUTS

Jump to: navigation, search

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000266	mitochondrial fission	FB:FBrf0202793 PMID:18230723^[1]	IGI: Inferred from Genetic Interaction	FB:FBgn0026479	P	From FB
	GO:0000266	mitochondrial fission	FB:FBrf0202793 PMID:18230723^[1]	IGI: Inferred from Genetic Interaction	FB:FBgn0029870	P	From FB
	GO:0000266	mitochondrial fission	FB:FBrf0202793 PMID:18230723^[1]	IGI: Inferred from Genetic Interaction	FB:FBgn0261276	P	From FB
	GO:0004842	ubiquitin-protein ligase activity	FB:FBrf0200499 PMID:17456438^[2]	IDA: Inferred from Direct Assay		F	From FB
	GO:0005737	cytoplasm	FB:FBrf0212264 PMID:20869429^[3]	IDA: Inferred from Direct Assay		C	From FB
	GO:0005739	mitochondrion	FB:FBrf0207333 PMID:18957282^[4]	IDA: Inferred from Direct Assay		C	From FB
	GO:0005829	cytosol	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR003977	C	From FB
	GO:0006979	response to oxidative stress	FB:FBrf0188281 PMID:15911761^[5]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007005	mitochondrion organization	FB:FBrf0159296 PMID:12642658^[6]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007005	mitochondrion organization	FB:FBrf0194793 PMID:17123504^[7]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007005	mitochondrion organization	FB:FBrf0202793 PMID:18230723^[1]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007005	mitochondrion organization	FB:FBrf0205047 PMID:18443288^[8]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007005	mitochondrion organization	FB:FBrf0206104 PMID:18799731^[9]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007283	spermatogenesis	FB:FBrf0194793 PMID:17123504^[7]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0008270	zinc ion binding	FB:FBrf0174215	IEA: Inferred from Electronic Annotation	InterPro:IPR002867	F	From FB
	GO:0010821	regulation of mitochondrion organization	FB:FBrf0208627 PMID:19546216^[10]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0016567	protein ubiquitination	FB:FBrf0200499 PMID:17456438^[2]	IDA: Inferred from Direct Assay		P	From FB
	GO:0030382	sperm mitochondrion organization	FB:FBrf0206104 PMID:18799731^[9]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0031624	ubiquitin conjugating enzyme binding	FB:FBrf0200499 PMID:17456438^[2]	IPI: Inferred from Physical Interaction	HGNC:12490	F	From FB
	GO:0046329	negative regulation of JNK cascade	FB:FBrf0188253 PMID:16002472^[11]	IDA: Inferred from Direct Assay		P	From FB
	GO:0048477	oogenesis	FB:FBrf0212264 PMID:20869429^[3]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0051865	protein autoubiquitination	FB:FBrf0200499 PMID:17456438^[2]	IDA: Inferred from Direct Assay		P	From FB
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Poole AC et al. (2008) The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A 105: 1638-43 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Bae YJ et al. (2007) Drosophila melanogaster Parkin ubiquitinates peanut and septin1 as an E3 ubiquitin-protein ligase. Insect Biochem Mol Biol 37: 430-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Ottone C et al. (2011) Diminution of eIF4E activity suppresses parkin mutant phenotypes. Gene 470: 12-9 PubMed GONUTS page
↑ Kim Y et al. (2008) PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun 377: 975-80 PubMed GONUTS page
↑ Whitworth AJ et al. (2005) Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc Natl Acad Sci U S A 102: 8024-9 PubMed GONUTS page
↑ Greene JC et al. (2003) Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci U S A 100: 4078-83 PubMed GONUTS page
↑ ^7.0 ^7.1 Riparbelli MG & Callaini G (2007) The Drosophila parkin homologue is required for normal mitochondrial dynamics during spermiogenesis. Dev Biol 303: 108-20 PubMed GONUTS page
↑ Yang Y et al. (2008) Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A 105: 7070-5 PubMed GONUTS page
↑ ^9.0 ^9.1 Deng H et al. (2008) The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A 105: 14503-8 PubMed GONUTS page
↑ Lutz AK et al. (2009) Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem 284: 22938-51 PubMed GONUTS page
↑ Cha GH et al. (2005) Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Proc Natl Acad Sci U S A 102: 10345-50 PubMed GONUTS page

[PMID:18230723-0] 1.0 ^1.1 ^1.2 ^1.3 Poole AC et al. (2008) The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A 105: 1638-43 PubMed GONUTS page

[PMID:17456438-1] 2.0 ^2.1 ^2.2 ^2.3 Bae YJ et al. (2007) Drosophila melanogaster Parkin ubiquitinates peanut and septin1 as an E3 ubiquitin-protein ligase. Insect Biochem Mol Biol 37: 430-9 PubMed GONUTS page

[PMID:20869429-2] 3.0 ^3.1 Ottone C et al. (2011) Diminution of eIF4E activity suppresses parkin mutant phenotypes. Gene 470: 12-9 PubMed GONUTS page

[PMID:18957282-3] Kim Y et al. (2008) PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun 377: 975-80 PubMed GONUTS page

[PMID:15911761-4] Whitworth AJ et al. (2005) Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc Natl Acad Sci U S A 102: 8024-9 PubMed GONUTS page

[PMID:12642658-5] Greene JC et al. (2003) Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc Natl Acad Sci U S A 100: 4078-83 PubMed GONUTS page

[PMID:17123504-6] 7.0 ^7.1 Riparbelli MG & Callaini G (2007) The Drosophila parkin homologue is required for normal mitochondrial dynamics during spermiogenesis. Dev Biol 303: 108-20 PubMed GONUTS page

[PMID:18443288-7] Yang Y et al. (2008) Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A 105: 7070-5 PubMed GONUTS page

[PMID:18799731-8] 9.0 ^9.1 Deng H et al. (2008) The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A 105: 14503-8 PubMed GONUTS page

[PMID:19546216-9] Lutz AK et al. (2009) Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem 284: 22938-51 PubMed GONUTS page

[PMID:16002472-10] Cha GH et al. (2005) Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Proc Natl Acad Sci U S A 102: 10345-50 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

Species (Taxon ID)	Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s)	park ( synonyms: CG10523, D-parkin, Dpark, Parkin, SD01679, dParkin, dparkin, dpk )
Protein Name(s)	parkin,
External Links
FB	FBgn0041100

FB:park

Contents

Annotations

Notes

References

c

m

n

o

p

r

s

s cont.

u

z

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox