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FB:p53
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | p53 ( synonyms: CG10873, CG31325, CG33336, D-p53, DMP53, Dm-P53, DmP53, Dmp53, Dp53, Drosophila p53, dmp53, dp53, p53-like regulator of apoptosis and cell cycle, prac, protein 53 ) | |
| Protein Name(s) | p53, | |
| External Links | ||
| FB | FBgn0039044 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
FB:FBrf0105495 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0127845 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0198837 |
IPI: Inferred from Physical Interaction |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0202871 |
IPI: Inferred from Physical Interaction |
FB:FBgn0031820 |
F |
From FB |
||
| GO:0005634 |
nucleus |
FB:FBrf0207542 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
FB:FBrf0161621 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0128885 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0149068 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0187472 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
FB:FBrf0202061 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006974 |
response to DNA damage stimulus |
FB:FBrf0173083 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006974 |
response to DNA damage stimulus |
FB:FBrf0208272 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007131 |
reciprocal meiotic recombination |
FB:FBrf0210965 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008134 |
transcription factor binding |
FB:FBrf0205137 |
IPI: Inferred from Physical Interaction |
FB:FBgn0026262 |
F |
From FB |
||
| GO:0008219 |
cell death |
FB:FBrf0159299 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008340 |
determination of adult lifespan |
FB:FBrf0189997 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008340 |
determination of adult lifespan |
FB:FBrf0198673 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008630 |
DNA damage response, signal transduction resulting in induction of apoptosis |
FB:FBrf0147184 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0008630 |
DNA damage response, signal transduction resulting in induction of apoptosis |
FB:FBrf0205772 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009314 |
response to radiation |
FB:FBrf0159299 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0009314 |
response to radiation |
FB:FBrf0161621 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0009411 |
response to UV |
FB:FBrf0190489 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010212 |
response to ionizing radiation |
FB:FBrf0202871 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030330 |
DNA damage response, signal transduction by p53 class mediator |
FB:FBrf0147184 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030330 |
DNA damage response, signal transduction by p53 class mediator |
FB:FBrf0149068 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0035234 |
germ cell programmed cell death |
FB:FBrf0212376 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042127 |
regulation of cell proliferation |
FB:FBrf0212630 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042246 |
tissue regeneration |
FB:FBrf0192041 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042771 |
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
FB:FBrf0127026 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042771 |
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
FB:FBrf0134532 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0042771 |
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
FB:FBrf0162129 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042771 |
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
FB:FBrf0192785 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0045787 |
positive regulation of cell cycle |
FB:FBrf0190213 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0019624 |
P |
From FB |
||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
FB:FBrf0127026 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
FB:FBrf0202871 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046533 |
negative regulation of photoreceptor cell differentiation |
FB:FBrf0210741 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046620 |
regulation of organ growth |
FB:FBrf0212630 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0210965 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0002989 |
P |
From FB |
||
|
colocalizes_with |
GO:0035327 |
transcriptionally active chromatin |
FB:FBrf0207542 |
IDA: Inferred from Direct Assay |
C |
From FB |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Yamasaki S et al. (2007) Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J 26: 113-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Bodai L et al. (2007) Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level. J Biol Chem 282: 36386-93 PubMed GONUTS page
- ↑ 3.0 3.1 Schauer T et al. (2009) Misregulated RNA Pol II C-terminal domain phosphorylation results in apoptosis. Cell Mol Life Sci 66: 909-18 PubMed GONUTS page
- ↑ De Laurenzi V & Melino G (2000) Apoptosis. The little devil of death. Nature 406: 135-6 PubMed GONUTS page
- ↑ 5.0 5.1 Richardson H & Kumar S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J Immunol Methods 265: 21-38 PubMed GONUTS page
- ↑ McEwen DG & Peifer M (2005) Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis. Development 132: 3935-46 PubMed GONUTS page
- ↑ Akdemir F et al. (2007) p53 directs focused genomic responses in Drosophila. Oncogene 26: 5184-93 PubMed GONUTS page
- ↑ Jassim OW et al. (2003) Dmp53 protects the Drosophila retina during a developmentally regulated DNA damage response. EMBO J 22: 5622-32 PubMed GONUTS page
- ↑ Ravi D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet 5: e1000527 PubMed GONUTS page
- ↑ 10.0 10.1 Lu WJ et al. (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328: 1278-81 PubMed GONUTS page
- ↑ Bereczki O et al. (2008) TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. BMC Mol Biol 9: 57 PubMed GONUTS page
- ↑ 12.0 12.1 Sogame N et al. (2003) Drosophila p53 preserves genomic stability by regulating cell death. Proc Natl Acad Sci U S A 100: 4696-701 PubMed GONUTS page
- ↑ 13.0 13.1 Bauer JH et al. (2005) Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr Biol 15: 2063-8 PubMed GONUTS page
- ↑ 14.0 14.1 Gorski S & Marra M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol Genomics 9: 59-69 PubMed GONUTS page
- ↑ Moon NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet 4: e1000153 PubMed GONUTS page
- ↑ Rebollar E et al. (2006) Role of the p53 homologue from Drosophila melanogaster in the maintenance of histone H3 acetylation and response to UV-light irradiation. FEBS Lett 580: 642-8 PubMed GONUTS page
- ↑ Bakhrat A et al. (2010) Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. Apoptosis 15: 1425-34 PubMed GONUTS page
- ↑ 18.0 18.1 Mesquita D et al. (2010) A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila. PLoS Biol 8: e1000566 PubMed GONUTS page
- ↑ Wells BS et al. (2006) Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr Biol 16: 1606-15 PubMed GONUTS page
- ↑ 20.0 20.1 Brodsky MH et al. (2000) Drosophila p53 binds a damage response element at the reaper locus. Cell 101: 103-13 PubMed GONUTS page
- ↑ Walworth NC (2000) Cell-cycle checkpoint kinases: checking in on the cell cycle. Curr Opin Cell Biol 12: 697-704 PubMed GONUTS page
- ↑ Lee JH et al. (2003) In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. FEBS Lett 550: 5-10 PubMed GONUTS page
- ↑ Colombani J et al. (2006) Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr Biol 16: 1453-8 PubMed GONUTS page
- ↑ Mandal S et al. (2005) Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev Cell 9: 843-54 PubMed GONUTS page
- ↑ Fan Y et al. (2010) Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ 17: 912-21 PubMed GONUTS page
