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FB:numb

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) numb ( synonyms: CG3779, N7-1, Nb, Numb, d-Numb, d-numb, dNumb, l(2)03235, l(2)3235, l(2)s2201, nb, numbs )
Protein Name(s) numb,
External Links
FB FBgn0002973

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001709

cell fate determination

FB:FBrf0174511
PMID:15018932[1]

NAS: Non-traceable Author Statement

P

From FB

GO:0003676

nucleic acid binding

FB:FBrf0123634

NAS: Non-traceable Author Statement

F

From FB

GO:0005112

Notch binding

FB:FBrf0180078
PMID:15324689[2]

TAS: Traceable Author Statement

F

From FB

GO:0005515

protein binding

FB:FBrf0099990
PMID:9418906[3]

IPI: Inferred from Physical Interaction

FB:FBgn0015772

F

From FB

GO:0005515

protein binding

FB:FBrf0174771
PMID:14670962[4]

IPI: Inferred from Physical Interaction

FB:FBgn0086711

F

From FB

GO:0005634

nucleus

FB:FBrf0123634

NAS: Non-traceable Author Statement

C

From FB

GO:0005737

cytoplasm

FB:FBrf0123233
PMID:10625542[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005737

cytoplasm

FB:FBrf0152260
PMID:12447381[6]

TAS: Traceable Author Statement

C

From FB

GO:0005938

cell cortex

FB:FBrf0190032
PMID:16243032[7]

IDA: Inferred from Direct Assay

C

From FB

GO:0007219

Notch signaling pathway

FB:FBrf0128431
PMID:10887088[8]

TAS: Traceable Author Statement

P

From FB

GO:0007400

neuroblast fate determination

FB:FBrf0128431
PMID:10887088[8]

TAS: Traceable Author Statement

P

From FB

GO:0007400

neuroblast fate determination

FB:FBrf0159207
PMID:12620217[9]

NAS: Non-traceable Author Statement

P

From FB

GO:0007405

neuroblast proliferation

FB:FBrf0188152
PMID:16142234[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007417

central nervous system development

FB:FBrf0156163
PMID:11697883[11]

TAS: Traceable Author Statement

P

From FB

GO:0007419

ventral cord development

FB:FBrf0158840
PMID:12593977[12]

NAS: Non-traceable Author Statement

P

From FB

GO:0007422

peripheral nervous system development

FB:FBrf0131381
PMID:11102367[13]

TAS: Traceable Author Statement

P

From FB

GO:0007507

heart development

FB:FBrf0151249
PMID:12027431[14]

TAS: Traceable Author Statement

P

From FB

GO:0007622

rhythmic behavior

FB:FBrf0155881
PMID:12486701[15]

TAS: Traceable Author Statement

P

From FB

GO:0008104

protein localization

FB:FBrf0188062
PMID:15901829[16]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008347

glial cell migration

FB:FBrf0191976
PMID:17157832[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0156161
PMID:11010805[18]

TAS: Traceable Author Statement

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0158840
PMID:12593977[12]

NAS: Non-traceable Author Statement

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0174511
PMID:15018932[1]

TAS: Traceable Author Statement

P

From FB

GO:0008593

regulation of Notch signaling pathway

FB:FBrf0151490
PMID:12127141[19]

TAS: Traceable Author Statement

P

From FB

GO:0009786

regulation of asymmetric cell division

FB:FBrf0206577
PMID:19088087[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016360

sensory organ precursor cell fate determination

FB:FBrf0123634

NAS: Non-traceable Author Statement

P

From FB

GO:0016360

sensory organ precursor cell fate determination

FB:FBrf0152260
PMID:12447381[6]

TAS: Traceable Author Statement

P

From FB

GO:0016360

sensory organ precursor cell fate determination

FB:FBrf0156163
PMID:11697883[11]

TAS: Traceable Author Statement

P

From FB

GO:0042694

muscle cell fate specification

FB:FBrf0187299
PMID:16139215[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045035

sensory organ precursor cell division

FB:FBrf0187299
PMID:16139215[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045165

cell fate commitment

FB:FBrf0151249
PMID:12027431[14]

TAS: Traceable Author Statement

P

From FB

GO:0045178

basal part of cell

FB:FBrf0132418
PMID:11117748[22]

NAS: Non-traceable Author Statement

C

From FB

GO:0045178

basal part of cell

FB:FBrf0156078
PMID:12185850[23]

TAS: Traceable Author Statement

C

From FB

GO:0045180

basal cortex

FB:FBrf0132417
PMID:11117747[24]

NAS: Non-traceable Author Statement

C

From FB

GO:0045180

basal cortex

FB:FBrf0156163
PMID:11697883[11]

NAS: Non-traceable Author Statement

C

From FB

GO:0045746

negative regulation of Notch signaling pathway

FB:FBrf0141528
PMID:11697879[25]

TAS: Traceable Author Statement

P

From FB

GO:0045746

negative regulation of Notch signaling pathway

FB:FBrf0152260
PMID:12447381[6]

TAS: Traceable Author Statement

P

From FB

GO:0045746

negative regulation of Notch signaling pathway

FB:FBrf0156161
PMID:11010805[18]

TAS: Traceable Author Statement

P

From FB

GO:0045746

negative regulation of Notch signaling pathway

FB:FBrf0174511
PMID:15018932[1]

TAS: Traceable Author Statement

P

From FB

GO:0045746

negative regulation of Notch signaling pathway

FB:FBrf0180078
PMID:15324689[2]

TAS: Traceable Author Statement

P

From FB

GO:0045807

positive regulation of endocytosis

FB:FBrf0187517
PMID:16113648[26]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050767

regulation of neurogenesis

FB:FBrf0194325
PMID:17182870[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050767

regulation of neurogenesis

FB:FBrf0195248
PMID:17182871[28]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0051960

regulation of nervous system development

FB:FBrf0206577
PMID:19088087[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0055059

asymmetric neuroblast division

FB:FBrf0156198
PMID:12137730[29]

TAS: Traceable Author Statement

P

From FB

GO:0055059

asymmetric neuroblast division

FB:FBrf0187299
PMID:16139215[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0061320

pericardial nephrocyte differentiation

FB:FBrf0187299
PMID:16139215[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0061382

Malpighian tubule tip cell differentiation

FB:FBrf0123233
PMID:10625542[5]

IMP: Inferred from Mutant Phenotype

P

From FB


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 Bardin AJ et al. (2004) Asymmetric localization and function of cell-fate determinants: a fly's view. Curr Opin Neurobiol 14: 6-14 PubMed GONUTS page
  2. ↑ 2.0 2.1 Betschinger J & Knoblich JA (2004) Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr Biol 14: R674-85 PubMed GONUTS page
  3. ↑ Chien CT et al. (1998) Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo. Mol Cell Biol 18: 598-607 PubMed GONUTS page
  4. ↑ Qin H et al. (2004) A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division. J Biol Chem 279: 11304-12 PubMed GONUTS page
  5. ↑ 5.0 5.1 Wan S et al. (2000) Multiple signalling pathways establish cell fate and cell number in Drosophila malpighian tubules. Dev Biol 217: 153-65 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Cayouette M & Raff M (2002) Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals. Nat Neurosci 5: 1265-9 PubMed GONUTS page
  7. ↑ Mayer B et al. (2005) Quantitative analysis of protein dynamics during asymmetric cell division. Curr Biol 15: 1847-54 PubMed GONUTS page
  8. ↑ 8.0 8.1 Cheah PY et al. (2000) Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates. Development 127: 3325-35 PubMed GONUTS page
  9. ↑ Tuxworth R & Chia W (2003) Asymmetric cell division: Miranda chauffeured by Jaguar? Mol Cell 11: 288-9 PubMed GONUTS page
  10. ↑ Caussinus E & Gonzalez C (2005) Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet 37: 1125-9 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 Schaefer M & Knoblich JA (2001) Protein localization during asymmetric cell division. Exp Cell Res 271: 66-74 PubMed GONUTS page
  12. ↑ 12.0 12.1 Skeath JB & Thor S (2003) Genetic control of Drosophila nerve cord development. Curr Opin Neurobiol 13: 8-15 PubMed GONUTS page
  13. ↑ Prokopenko SN et al. (2000) Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins. Genetics 156: 1691-715 PubMed GONUTS page
  14. ↑ 14.0 14.1 Cripps RM & Olson EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 246: 14-28 PubMed GONUTS page
  15. ↑ Stanewsky R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J Neurobiol 54: 111-47 PubMed GONUTS page
  16. ↑ Roegiers F et al. (2005) Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol Biol Cell 16: 3480-7 PubMed GONUTS page
  17. ↑ Edenfeld G et al. (2007) Notch and Numb are required for normal migration of peripheral glia in Drosophila. Dev Biol 301: 27-37 PubMed GONUTS page
  18. ↑ 18.0 18.1 Kadesch T (2000) Notch signaling: a dance of proteins changing partners. Exp Cell Res 260: 1-8 PubMed GONUTS page
  19. ↑ Stewart BA (2002) Membrane trafficking in Drosophila wing and eye development. Semin Cell Dev Biol 13: 91-7 PubMed GONUTS page
  20. ↑ 20.0 20.1 Gaziova I & Bhat KM (2009) Ancestry-independent fate specification and plasticity in the developmental timing of a typical Drosophila neuronal lineage. Development 136: 263-74 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 21.3 Bhalerao S et al. (2005) Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila. Curr Biol 15: 1583-90 PubMed GONUTS page
  22. ↑ Peng CY et al. (2000) The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 408: 596-600 PubMed GONUTS page
  23. ↑ Gönczy P (2002) Mechanisms of spindle positioning: focus on flies and worms. Trends Cell Biol 12: 332-9 PubMed GONUTS page
  24. ↑ Ohshiro T et al. (2000) Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408: 593-6 PubMed GONUTS page
  25. ↑ Narayanan R & Ramaswami M (2001) Endocytosis in Drosophila: progress, possibilities, prognostications. Exp Cell Res 271: 28-35 PubMed GONUTS page
  26. ↑ Hutterer A & Knoblich JA (2005) Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. EMBO Rep 6: 836-42 PubMed GONUTS page
  27. ↑ Wang H et al. (2006) Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev 20: 3453-63 PubMed GONUTS page
  28. ↑ Lee CY et al. (2006) Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev 20: 3464-74 PubMed GONUTS page
  29. ↑ Tree DR et al. (2002) A three-tiered mechanism for regulation of planar cell polarity. Semin Cell Dev Biol 13: 217-24 PubMed GONUTS page
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