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FB:mth

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) mth ( synonyms: CG6936, MTH, Methuselah, Mth, methusalah )
Protein Name(s) methuselah,
External Links
FB FBgn0023000

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004930

G-protein coupled receptor activity

FB:FBrf0117448

NAS: Non-traceable Author Statement

F

From FB

GO:0004930

G-protein coupled receptor activity

FB:FBrf0129744
PMID:10908591[1]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0004930

G-protein coupled receptor activity

FB:FBrf0152099
PMID:12163486[2]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0004930

G-protein coupled receptor activity

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000832
InterPro:IPR010596

F

From FB

GO:0006950

response to stress

FB:FBrf0105270
PMID:9794765[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0006950

response to stress

FB:FBrf0129744
PMID:10908591[1]

TAS: Traceable Author Statement

P

From FB

GO:0006950

response to stress

FB:FBrf0151033

NAS: Non-traceable Author Statement

P

From FB

GO:0006979

response to oxidative stress

FB:FBrf0155558
PMID:12539239[4]

NAS: Non-traceable Author Statement

P

From FB

GO:0007186

G-protein coupled receptor signaling pathway

FB:FBrf0129744
PMID:10908591[1]

ISS: Inferred from Sequence or Structural Similarity

P

From FB

GO:0007186

G-protein coupled receptor signaling pathway

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000832

P

From FB

GO:0007568

aging

FB:FBrf0151033

NAS: Non-traceable Author Statement

P

From FB

GO:0007568

aging

FB:FBrf0157351
PMID:11707917[5]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0105270
PMID:9794765[3]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0125364
PMID:10638521[6]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0129744
PMID:10908591[1]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0130068
PMID:10995474[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0135874
PMID:11348656[8]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0155558
PMID:12539239[4]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0155931
PMID:12470891[9]

TAS: Traceable Author Statement

P

From FB

GO:0008340

determination of adult lifespan

FB:FBrf0167266
PMID:14616064[10]

TAS: Traceable Author Statement

P

From FB

GO:0009408

response to heat

FB:FBrf0135874
PMID:11348656[8]

TAS: Traceable Author Statement

P

From FB

GO:0009408

response to heat

FB:FBrf0155931
PMID:12470891[9]

NAS: Non-traceable Author Statement

P

From FB

GO:0016021

integral to membrane

FB:FBrf0129744
PMID:10908591[1]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0016021

integral to membrane

FB:FBrf0155558
PMID:12539239[4]

TAS: Traceable Author Statement

C

From FB

GO:0016021

integral to membrane

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000832

C

From FB

GO:0016079

synaptic vesicle exocytosis

FB:FBrf0152269
PMID:12367510[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042594

response to starvation

FB:FBrf0135874
PMID:11348656[8]

TAS: Traceable Author Statement

P

From FB

GO:0042594

response to starvation

FB:FBrf0155931
PMID:12470891[9]

NAS: Non-traceable Author Statement

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 Brody T & Cravchik A (2000) Drosophila melanogaster G protein-coupled receptors. J Cell Biol 150: F83-8 PubMed GONUTS page
  2. Radford JC et al. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles. J Biol Chem 277: 38810-7 PubMed GONUTS page
  3. 3.0 3.1 Lin YJ et al. (1998) Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 282: 943-6 PubMed GONUTS page
  4. 4.0 4.1 4.2 Helfand SL & Rogina B (2003) Molecular genetics of aging in the fly: is this the end of the beginning? Bioessays 25: 134-41 PubMed GONUTS page
  5. Luckinbill LS & Foley P (2000) Experimental and empirical approaches in the study of aging. Biogerontology 1: 3-13 PubMed GONUTS page
  6. Longo VD (1999) Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells. Neurobiol Aging 20: 479-86 PubMed GONUTS page
  7. Schmidt PS et al. (2000) Adaptive evolution of a candidate gene for aging in Drosophila. Proc Natl Acad Sci U S A 97: 10861-5 PubMed GONUTS page
  8. 8.0 8.1 8.2 Boulianne GL (2001) Neuronal regulation of lifespan: clues from flies and worms. Mech Ageing Dev 122: 883-94 PubMed GONUTS page
  9. 9.0 9.1 9.2 Aigaki T et al. (2002) Longevity determination genes in Drosophila melanogaster. Mech Ageing Dev 123: 1531-41 PubMed GONUTS page
  10. Helfand SL & Rogina B (2003) Genetics of aging in the fruit fly, Drosophila melanogaster. Annu Rev Genet 37: 329-48 PubMed GONUTS page
  11. Song W et al. (2002) Presynaptic regulation of neurotransmission in Drosophila by the g protein-coupled receptor methuselah. Neuron 36: 105-19 PubMed GONUTS page
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