GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:msn
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | msn ( synonyms: 6286, CG16973, DMSN, HGK, JNKKKK, MESR5, MSN, Mishappen, Misshapen, Msn, NIK, Nik, l(3)03349, l(3)06946, l(3)6286, l(3)j1E2, msm ) | |
| Protein Name(s) | misshapen, | |
| External Links | ||
| FB | FBgn0010909 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000185 |
activation of MAPKKK activity |
FB:FBrf0103375 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0001736 |
establishment of planar polarity |
FB:FBrf0156094 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0001748 |
optic lobe placode development |
FB:FBrf0180490 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0101288 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0111489 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0004702 |
receptor signaling protein serine/threonine kinase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005083 |
small GTPase regulator activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005938 |
cell cortex |
FB:FBrf0193431 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0092708 |
ISS: Inferred from Sequence or Structural Similarity |
FB:FBgn0002938 |
P |
From FB |
||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0092708 |
ISS: Inferred from Sequence or Structural Similarity |
SGD:S0000072 |
P |
From FB |
||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0111489 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007097 |
nuclear migration |
FB:FBrf0180490 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007254 |
JNK cascade |
FB:FBrf0103375 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000229 |
P |
From FB |
||
| GO:0007254 |
JNK cascade |
FB:FBrf0103375 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010303 |
P |
From FB |
||
| GO:0007254 |
JNK cascade |
FB:FBrf0103375 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007254 |
JNK cascade |
FB:FBrf0103375 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From FB |
|||
| GO:0007254 |
JNK cascade |
FB:FBrf0110443 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0103375 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0000229 |
P |
From FB |
||
| GO:0007391 |
dorsal closure |
FB:FBrf0103375 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010303 |
P |
From FB |
||
| GO:0007391 |
dorsal closure |
FB:FBrf0103375 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0110443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0149002 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0151280 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0184059 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0193431 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0210319 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008349 |
MAP kinase kinase kinase kinase activity |
FB:FBrf0103375 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0008349 |
MAP kinase kinase kinase kinase activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
SGD:S0000999 |
F |
From FB |
||
| GO:0008349 |
MAP kinase kinase kinase kinase activity |
FB:FBrf0144880 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0008360 |
regulation of cell shape |
FB:FBrf0092708 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008594 |
photoreceptor cell morphogenesis |
FB:FBrf0092708 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016476 |
regulation of embryonic cell shape |
FB:FBrf0193431 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042656 |
JUN kinase kinase kinase kinase activity |
FB:FBrf0151872 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0046529 |
imaginal disc fusion, thorax closure |
FB:FBrf0184059 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048477 |
oogenesis |
FB:FBrf0092708 |
NAS: Non-traceable Author Statement |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Su YC et al. (1998) The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway. Genes Dev 12: 2371-80 PubMed GONUTS page
- ↑ Mlodzik M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet 18: 564-71 PubMed GONUTS page
- ↑ 3.0 3.1 Houalla T et al. (2005) The Ste20-like kinase misshapen functions together with Bicaudal-D and dynein in driving nuclear migration in the developing drosophila eye. Mech Dev 122: 97-108 PubMed GONUTS page
- ↑ 4.0 4.1 Spradling AC et al. (1999) The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics 153: 135-77 PubMed GONUTS page
- ↑ 5.0 5.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Köppen M et al. (2006) Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. Development 133: 2671-81 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Treisman JE et al. (1997) misshapen encodes a protein kinase involved in cell shape control in Drosophila. Gene 186: 119-25 PubMed GONUTS page
- ↑ 8.0 8.1 Noselli S & Agnès F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr Opin Genet Dev 9: 466-72 PubMed GONUTS page
- ↑ Van Aelst L & Symons M (2002) Role of Rho family GTPases in epithelial morphogenesis. Genes Dev 16: 1032-54 PubMed GONUTS page
- ↑ Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
- ↑ 11.0 11.1 Kadrmas JL et al. (2004) The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. J Cell Biol 167: 1019-24 PubMed GONUTS page
- ↑ Berger J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet 4: e1000085 PubMed GONUTS page
- ↑ Stronach B & Perrimon N (2002) Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev 16: 377-87 PubMed GONUTS page
- ↑ Martin P & Wood W (2002) Epithelial fusions in the embryo. Curr Opin Cell Biol 14: 569-74 PubMed GONUTS page
