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FB:lz

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) lz ( synonyms: CG1689, Lozenge, Lz, amx, fs(1)A1569, fs(1)M69, spe, spectacled )
Protein Name(s) lozenge,
External Links
FB FBgn0002576

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0086985
PMID:8675007[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0003651

P

From FB

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0131266
PMID:11105896[2]

TAS: Traceable Author Statement

P

From FB

GO:0001709

cell fate determination

FB:FBrf0144845
PMID:11798069[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0003677

DNA binding

FB:FBrf0187601
PMID:15879554[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0086985
PMID:8675007[1]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0003300

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0086985
PMID:8675007[1]

ISS: Inferred from Sequence or Structural Similarity

HGNC:10471

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0133282

NAS: Non-traceable Author Statement

F

From FB

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0131266
PMID:11105896[2]

NAS: Non-traceable Author Statement

F

From FB

GO:0005524

ATP binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000040

F

From FB

GO:0005634

nucleus

FB:FBrf0086985
PMID:8675007[1]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0003300

C

From FB

GO:0005634

nucleus

FB:FBrf0086985
PMID:8675007[1]

ISS: Inferred from Sequence or Structural Similarity

HGNC:10471

C

From FB

GO:0005634

nucleus

FB:FBrf0086985
PMID:8675007[1]

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:99829

C

From FB

GO:0005634

nucleus

FB:FBrf0187601
PMID:15879554[4]

IC: Inferred by Curator

GO:0003677

C

From FB

GO:0005634

nucleus

FB:FBrf0213054
PMID:21343364[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0006952

defense response

FB:FBrf0133282

NAS: Non-traceable Author Statement

P

From FB

GO:0007165

signal transduction

FB:FBrf0131266
PMID:11105896[2]

NAS: Non-traceable Author Statement

P

From FB

GO:0007469

antennal development

FB:FBrf0131266
PMID:11105896[2]

TAS: Traceable Author Statement

P

From FB

GO:0007486

imaginal disc-derived female genitalia development

FB:FBrf0213054
PMID:21343364[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016360

sensory organ precursor cell fate determination

FB:FBrf0179899
PMID:15313555[6]

TAS: Traceable Author Statement

P

From FB

GO:0030097

hemopoiesis

FB:FBrf0131266
PMID:11105896[2]

TAS: Traceable Author Statement

P

From FB

GO:0030097

hemopoiesis

FB:FBrf0141068
PMID:11283698[7]

TAS: Traceable Author Statement

P

From FB

GO:0030154

cell differentiation

FB:FBrf0131266
PMID:11105896[2]

TAS: Traceable Author Statement

P

From FB

GO:0035162

embryonic hemopoiesis

FB:FBrf0127186
PMID:10753120[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035163

embryonic hemocyte differentiation

FB:FBrf0187450
PMID:16176949[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035165

embryonic crystal cell differentiation

FB:FBrf0127186
PMID:10753120[8]

IEP: Inferred from Expression Pattern

P

From FB

GO:0035165

embryonic crystal cell differentiation

FB:FBrf0131266
PMID:11105896[2]

TAS: Traceable Author Statement

P

From FB

GO:0035165

embryonic crystal cell differentiation

FB:FBrf0187450
PMID:16176949[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035168

larval lymph gland hemocyte differentiation

FB:FBrf0167476
PMID:14602069[10]

TAS: Traceable Author Statement

P

From FB

GO:0035170

lymph gland crystal cell differentiation

FB:FBrf0167434
PMID:14734104[11]

TAS: Traceable Author Statement

P

From FB

GO:0035211

spermathecum morphogenesis

FB:FBrf0158848
PMID:12679097[12]

TAS: Traceable Author Statement

P

From FB

GO:0035314

scab formation

FB:FBrf0179215
PMID:15269788[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042060

wound healing

FB:FBrf0179215
PMID:15269788[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042675

compound eye cone cell differentiation

FB:FBrf0187490
PMID:15829516[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042688

crystal cell differentiation

FB:FBrf0127186
PMID:10753120[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042688

crystal cell differentiation

FB:FBrf0133282

NAS: Non-traceable Author Statement

P

From FB

GO:0042688

crystal cell differentiation

FB:FBrf0144845
PMID:11798069[3]

TAS: Traceable Author Statement

P

From FB

GO:0042688

crystal cell differentiation

FB:FBrf0151252
PMID:12167411[15]

TAS: Traceable Author Statement

P

From FB

GO:0042688

crystal cell differentiation

FB:FBrf0158758
PMID:12732186[16]

TAS: Traceable Author Statement

P

From FB

GO:0042688

crystal cell differentiation

FB:FBrf0167476
PMID:14602069[10]

TAS: Traceable Author Statement

P

From FB

GO:0042981

regulation of apoptotic process

FB:FBrf0187601
PMID:15879554[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0195108
PMID:16730345[17]

IDA: Inferred from Direct Assay

F

From FB

GO:0045165

cell fate commitment

FB:FBrf0131266
PMID:11105896[2]

TAS: Traceable Author Statement

P

From FB

GO:0045467

R7 cell development

FB:FBrf0209609
PMID:20003234[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0086985
PMID:8675007[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0000154

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0131266
PMID:11105896[2]

TAS: Traceable Author Statement

P

From FB

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

FB:FBrf0187601
PMID:15879554[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046672

positive regulation of compound eye retinal cell programmed cell death

FB:FBrf0187601
PMID:15879554[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048477

oogenesis

FB:FBrf0044470
PMID:3089870[19]

TAS: Traceable Author Statement

P

From FB

GO:0048592

eye morphogenesis

FB:FBrf0187490
PMID:15829516[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048749

compound eye development

FB:FBrf0131266
PMID:11105896[2]

TAS: Traceable Author Statement

P

From FB

GO:0048749

compound eye development

FB:FBrf0144845
PMID:11798069[3]

TAS: Traceable Author Statement

P

From FB

GO:0048749

compound eye development

FB:FBrf0209609
PMID:20003234[18]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Daga A et al. (1996) Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1. Genes Dev 10: 1194-205 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Canon J & Banerjee U (2000) Runt and Lozenge function in Drosophila development. Semin Cell Dev Biol 11: 327-36 PubMed GONUTS page
  3. 3.0 3.1 3.2 Fossett N & Schulz RA (2001) Functional conservation of hematopoietic factors in Drosophila and vertebrates. Differentiation 69: 83-90 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Wildonger J et al. (2005) Lozenge directly activates argos and klumpfuss to regulate programmed cell death. Genes Dev 19: 1034-9 PubMed GONUTS page
  5. 5.0 5.1 Chatterjee SS et al. (2011) The female-specific doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. Development 138: 1099-109 PubMed GONUTS page
  6. Hallem EA & Carlson JR (2004) The odor coding system of Drosophila. Trends Genet 20: 453-9 PubMed GONUTS page
  7. Kimbrell DA & Beutler B (2001) The evolution and genetics of innate immunity. Nat Rev Genet 2: 256-67 PubMed GONUTS page
  8. 8.0 8.1 8.2 Lebestky T et al. (2000) Specification of Drosophila hematopoietic lineage by conserved transcription factors. Science 288: 146-9 PubMed GONUTS page
  9. 9.0 9.1 Bataillé L et al. (2005) Resolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors. Development 132: 4635-44 PubMed GONUTS page
  10. 10.0 10.1 Evans CJ et al. (2003) Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis. Dev Cell 5: 673-90 PubMed GONUTS page
  11. Meister M (2004) Blood cells of Drosophila: cell lineages and role in host defence. Curr Opin Immunol 16: 10-5 PubMed GONUTS page
  12. Bloch Qazi MC et al. (2003) The developments between gametogenesis and fertilization: ovulation and female sperm storage in Drosophila melanogaster. Dev Biol 256: 195-211 PubMed GONUTS page
  13. 13.0 13.1 Galko MJ & Krasnow MA (2004) Cellular and genetic analysis of wound healing in Drosophila larvae. PLoS Biol 2: E239 PubMed GONUTS page
  14. 14.0 14.1 Wildonger J & Mann RS (2005) The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor. Development 132: 2263-72 PubMed GONUTS page
  15. Alfonso TB & Jones BW (2002) gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila. Dev Biol 248: 369-83 PubMed GONUTS page
  16. Evans CJ & Banerjee U (2003) Transcriptional regulation of hematopoiesis in Drosophila. Blood Cells Mol Dis 30: 223-8 PubMed GONUTS page
  17. Muratoglu S et al. (2006) Regulation of Drosophila friend of GATA gene, u-shaped, during hematopoiesis: a direct role for serpent and lozenge. Dev Biol 296: 561-79 PubMed GONUTS page
  18. 18.0 18.1 Siddall NA et al. (2009) Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc. BMC Dev Biol 9: 64 PubMed GONUTS page
  19. Perrimon N et al. (1986) X-linked female-sterile loci in Drosophila melanogaster. Genetics 113: 695-712 PubMed GONUTS page
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