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FB:lea

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) lea ( synonyms: CG14347, CG14348, CG5481, CG5574, CT17326, D-Robo2, D-robo2, Leak, ROBO2, Robo 2, Robo-2, Robo2, Roundabout 2, Roundabout2, SGP cluster fusion defects 4, anon-EST:Liang-1.75, clone 1.75, dRobo-2, fus4, robo-2, robo2, roundabout 2, roundabout2 )
Protein Name(s) leak,
External Links
FB FBgn0002543

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001764

neuron migration

FB:FBrf0180051
PMID:15296748[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0003151

outflow tract morphogenesis

FB:FBrf0204371
PMID:18250318[2]

IGI: Inferred from Genetic Interaction

FB:FBgn0005631

P

From FB

GO:0004872

receptor activity

FB:FBrf0160886
PMID:12885551[3]

TAS: Traceable Author Statement

F

From FB

GO:0005886

plasma membrane

FB:FBrf0133049

NAS: Non-traceable Author Statement

C

From FB

GO:0007411

axon guidance

FB:FBrf0126093

IGI: Inferred from Genetic Interaction

FB:FBgn0005631

P

From FB

GO:0007411

axon guidance

FB:FBrf0126093

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0132431
PMID:11163264[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0132432
PMID:11163265[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0155635
PMID:11891122[6]

TAS: Traceable Author Statement

P

From FB

GO:0007411

axon guidance

FB:FBrf0174568
PMID:15056612[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007419

ventral cord development

FB:FBrf0132431
PMID:11163264[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007419

ventral cord development

FB:FBrf0132432
PMID:11163265[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007426

tracheal outgrowth, open tracheal system

FB:FBrf0161023
PMID:12791296[8]

TAS: Traceable Author Statement

P

From FB

GO:0007432

salivary gland boundary specification

FB:FBrf0187388
PMID:15950216[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008046

axon guidance receptor activity

FB:FBrf0133049

NAS: Non-traceable Author Statement

F

From FB

GO:0008406

gonad development

FB:FBrf0213539
PMID:21377458[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016319

mushroom body development

FB:FBrf0190257
PMID:16003521[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0022409

positive regulation of cell-cell adhesion

FB:FBrf0194038
PMID:16888037[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035050

embryonic heart tube development

FB:FBrf0190040
PMID:16360689[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035050

embryonic heart tube development

FB:FBrf0190142
PMID:16516189[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035050

embryonic heart tube development

FB:FBrf0194038
PMID:16888037[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042685

cardioblast cell fate specification

FB:FBrf0194038
PMID:16888037[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048036

central complex development

FB:FBrf0190257
PMID:16003521[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:2000274

regulation of epithelial cell migration, open tracheal system

FB:FBrf0151931
PMID:12397103[15]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Kraut R & Zinn K (2004) Roundabout 2 regulates migration of sensory neurons by signaling in trans. Curr Biol 14: 1319-29 PubMed GONUTS page
  2. Zmojdzian M et al. (2008) Cellular components and signals required for the cardiac outflow tract assembly in Drosophila. Proc Natl Acad Sci U S A 105: 2475-80 PubMed GONUTS page
  3. Ribeiro C et al. (2003) Signaling systems, guided cell migration, and organogenesis: insights from genetic studies in Drosophila. Dev Biol 260: 1-8 PubMed GONUTS page
  4. 4.0 4.1 Simpson JH et al. (2000) Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance. Neuron 28: 753-66 PubMed GONUTS page
  5. 5.0 5.1 Rajagopalan S et al. (2000) Crossing the midline: roles and regulation of Robo receptors. Neuron 28: 767-77 PubMed GONUTS page
  6. Patel BN & Van Vactor DL (2002) Axon guidance: the cytoplasmic tail. Curr Opin Cell Biol 14: 221-9 PubMed GONUTS page
  7. Jhaveri D et al. (2004) Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling. Development 131: 1903-12 PubMed GONUTS page
  8. Uv A et al. (2003) Drosophila tracheal morphogenesis: intricate cellular solutions to basic plumbing problems. Trends Cell Biol 13: 301-9 PubMed GONUTS page
  9. Kolesnikov T & Beckendorf SK (2005) NETRIN and SLIT guide salivary gland migration. Dev Biol 284: 102-11 PubMed GONUTS page
  10. Weyers JJ et al. (2011) A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. Dev Biol 353: 217-28 PubMed GONUTS page
  11. 11.0 11.1 Nicolas E & Preat T (2005) Drosophila central brain formation requires Robo proteins. Dev Genes Evol 215: 530-6 PubMed GONUTS page
  12. 12.0 12.1 12.2 Santiago-Martínez E et al. (2006) Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration. Proc Natl Acad Sci U S A 103: 12441-6 PubMed GONUTS page
  13. Qian L et al. (2005) Slit and Robo control cardiac cell polarity and morphogenesis. Curr Biol 15: 2271-8 PubMed GONUTS page
  14. MacMullin A & Jacobs JR (2006) Slit coordinates cardiac morphogenesis in Drosophila. Dev Biol 293: 154-64 PubMed GONUTS page
  15. Englund C et al. (2002) Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea. Development 129: 4941-51 PubMed GONUTS page
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