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FB:l(2)gl

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) l(2)gl ( synonyms: CG2671, Complementation group 2.1, D-LGL, L(2)GL, L(2)gl, LGL, Lethal (2) giant larva, Lethal (2) giant larvae, Lethal Giant Larvae, Lethal giant larvae, Lethal-giant-larvae, Lgl, MENE (2L)-B, dlgl, gl, l(2), l(2) giant larva, l(2) giant larvae, l(2)giant larvae, l-gl, l((2))gl, lethal giant larva, lethal giant larvae, lethal giant larve, lethal(2) giant larvae, lethal(2)-giant larvae, lethal(2)giant larvae, lethal- giant-larvae, lethal-2-giant larvae, lethal-giant-larvae, lgl, p127, p127(l(2)gl), p127l(2)gl )
Protein Name(s) lethal (2) giant larvae,
External Links
FB FBgn0002121

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001738

morphogenesis of a polarized epithelium

FB:FBrf0167430
PMID:14644201[1]

TAS: Traceable Author Statement

P

From FB

GO:0002009

morphogenesis of an epithelium

FB:FBrf0141282
PMID:11700298[2]

TAS: Traceable Author Statement

P

From FB

GO:0005578

proteinaceous extracellular matrix

FB:FBrf0044240
PMID:12222562[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0005614

interstitial matrix

FB:FBrf0123445

NAS: Non-traceable Author Statement

C

From FB

GO:0005737

cytoplasm

FB:FBrf0132417
PMID:11117747[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005737

cytoplasm

FB:FBrf0132418
PMID:11117748[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005829

cytosol

FB:FBrf0128403
PMID:10884224[6]

TAS: Traceable Author Statement

C

From FB

GO:0005856

cytoskeleton

FB:FBrf0110443
PMID:10449347[7]

NAS: Non-traceable Author Statement

C

From FB

GO:0005886

plasma membrane

FB:FBrf0044240
PMID:12222562[3]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0123445

NAS: Non-traceable Author Statement

C

From FB

GO:0005886

plasma membrane

FB:FBrf0128403
PMID:10884224[6]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0128403
PMID:10884224[6]

TAS: Traceable Author Statement

C

From FB

GO:0005918

septate junction

FB:FBrf0141282
PMID:11700298[2]

NAS: Non-traceable Author Statement

C

From FB

GO:0005918

septate junction

FB:FBrf0155581
PMID:12500938[8]

TAS: Traceable Author Statement

C

From FB

GO:0005938

cell cortex

FB:FBrf0132417
PMID:11117747[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0005938

cell cortex

FB:FBrf0132418
PMID:11117748[5]

IDA: Inferred from Direct Assay

C

From FB

GO:0005938

cell cortex

FB:FBrf0141473
PMID:11784030[9]

TAS: Traceable Author Statement

C

From FB

GO:0007179

transforming growth factor beta receptor signaling pathway

FB:FBrf0137221
PMID:11493541[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0000490

P

From FB

GO:0007179

transforming growth factor beta receptor signaling pathway

FB:FBrf0137221
PMID:11493541[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007269

neurotransmitter secretion

FB:FBrf0127207
PMID:10798391[11]

NAS: Non-traceable Author Statement

P

From FB

GO:0007314

oocyte anterior/posterior axis specification

FB:FBrf0203052
PMID:18094021[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007391

dorsal closure

FB:FBrf0110443
PMID:10449347[7]

TAS: Traceable Author Statement

P

From FB

GO:0007391

dorsal closure

FB:FBrf0151280
PMID:12147138[13]

TAS: Traceable Author Statement

P

From FB

GO:0007399

nervous system development

FB:FBrf0132417
PMID:11117747[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007406

negative regulation of neuroblast proliferation

FB:FBrf0189901
PMID:16564014[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007423

sensory organ development

FB:FBrf0158820
PMID:12725738[15]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007559

histolysis

FB:FBrf0146208

NAS: Non-traceable Author Statement

P

From FB

GO:0008021

synaptic vesicle

FB:FBrf0127207
PMID:10798391[11]

NAS: Non-traceable Author Statement

C

From FB

GO:0008104

protein localization

FB:FBrf0157330
PMID:12141438[16]

TAS: Traceable Author Statement

P

From FB

GO:0008105

asymmetric protein localization

FB:FBrf0155643
PMID:12231350[17]

TAS: Traceable Author Statement

P

From FB

GO:0008105

asymmetric protein localization

FB:FBrf0155996
PMID:12545176[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008283

cell proliferation

FB:FBrf0128403
PMID:10884224[6]

TAS: Traceable Author Statement

P

From FB

GO:0008285

negative regulation of cell proliferation

FB:FBrf0159915
PMID:12766944[19]

TAS: Traceable Author Statement

P

From FB

GO:0008360

regulation of cell shape

FB:FBrf0151280
PMID:12147138[13]

NAS: Non-traceable Author Statement

P

From FB

GO:0016082

synaptic vesicle priming

FB:FBrf0127207
PMID:10798391[11]

NAS: Non-traceable Author Statement

P

From FB

GO:0016323

basolateral plasma membrane

FB:FBrf0167430
PMID:14644201[1]

TAS: Traceable Author Statement

C

From FB

GO:0016325

oocyte microtubule cytoskeleton organization

FB:FBrf0203052
PMID:18094021[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016327

apicolateral plasma membrane

FB:FBrf0128403
PMID:10884224[6]

IDA: Inferred from Direct Assay

C

From FB

GO:0016332

establishment or maintenance of polarity of embryonic epithelium

FB:FBrf0132417
PMID:11117747[4]

TAS: Traceable Author Statement

P

From FB

GO:0016332

establishment or maintenance of polarity of embryonic epithelium

FB:FBrf0132418
PMID:11117748[5]

TAS: Traceable Author Statement

P

From FB

GO:0016333

morphogenesis of follicular epithelium

FB:FBrf0128403
PMID:10884224[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016334

establishment or maintenance of polarity of follicular epithelium

FB:FBrf0128403
PMID:10884224[6]

IGI: Inferred from Genetic Interaction

FB:FBgn0001624

P

From FB

GO:0016335

morphogenesis of larval imaginal disc epithelium

FB:FBrf0128403
PMID:10884224[6]

TAS: Traceable Author Statement

P

From FB

GO:0016336

establishment or maintenance of polarity of larval imaginal disc epithelium

FB:FBrf0128403
PMID:10884224[6]

TAS: Traceable Author Statement

P

From FB

GO:0017022

myosin binding

FB:FBrf0132418
PMID:11117748[5]

IGI: Inferred from Genetic Interaction

FB:FBgn0005634

F

From FB

GO:0019991

septate junction assembly

FB:FBrf0151280
PMID:12147138[13]

TAS: Traceable Author Statement

P

From FB

GO:0030036

actin cytoskeleton organization

FB:FBrf0203052
PMID:18094021[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0030154

cell differentiation

FB:FBrf0123445

NAS: Non-traceable Author Statement

P

From FB

GO:0030863

cortical cytoskeleton

FB:FBrf0127068
PMID:10713724[20]

IDA: Inferred from Direct Assay

C

From FB

GO:0035070

salivary gland histolysis

FB:FBrf0127068
PMID:10713724[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035072

ecdysone-mediated induction of salivary gland cell autophagic cell death

FB:FBrf0127068
PMID:10713724[20]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035072

ecdysone-mediated induction of salivary gland cell autophagic cell death

FB:FBrf0146208

NAS: Non-traceable Author Statement

P

From FB

GO:0035212

cell competition in a multicellular organism

FB:FBrf0211298
PMID:20644714[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035293

chitin-based larval cuticle pattern formation

FB:FBrf0213500
PMID:19737741[22]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042127

regulation of cell proliferation

FB:FBrf0123445

NAS: Non-traceable Author Statement

P

From FB

GO:0045159

myosin II binding

FB:FBrf0132417
PMID:11117747[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0005634

F

From FB

GO:0045159

myosin II binding

FB:FBrf0141473
PMID:11784030[9]

TAS: Traceable Author Statement

F

From FB

GO:0045159

myosin II binding

FB:FBrf0151280
PMID:12147138[13]

TAS: Traceable Author Statement

F

From FB

GO:0045167

asymmetric protein localization involved in cell fate determination

FB:FBrf0156163
PMID:11697883[23]

TAS: Traceable Author Statement

P

From FB

GO:0045167

asymmetric protein localization involved in cell fate determination

FB:FBrf0157155
PMID:12629552[24]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045167

asymmetric protein localization involved in cell fate determination

FB:FBrf0157155
PMID:12629552[24]

IPI: Inferred from Physical Interaction

FB:FBgn0026192

P

From FB

GO:0045167

asymmetric protein localization involved in cell fate determination

FB:FBrf0174511
PMID:15018932[25]

TAS: Traceable Author Statement

P

From FB

GO:0045175

basal protein localization

FB:FBrf0132417
PMID:11117747[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045175

basal protein localization

FB:FBrf0132418
PMID:11117748[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045175

basal protein localization

FB:FBrf0155686
PMID:12586070[26]

IGI: Inferred from Genetic Interaction

FB:FBgn0011225

P

From FB

GO:0045175

basal protein localization

FB:FBrf0156163
PMID:11697883[23]

NAS: Non-traceable Author Statement

P

From FB

GO:0045175

basal protein localization

FB:FBrf0159207
PMID:12620217[27]

NAS: Non-traceable Author Statement

P

From FB

GO:0045184

establishment of protein localization

FB:FBrf0132417
PMID:11117747[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045196

establishment or maintenance of neuroblast polarity

FB:FBrf0141282
PMID:11700298[2]

TAS: Traceable Author Statement

P

From FB

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

FB:FBrf0141282
PMID:11700298[2]

TAS: Traceable Author Statement

P

From FB

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

FB:FBrf0141377
PMID:11782950[28]

NAS: Non-traceable Author Statement

P

From FB

GO:0045197

establishment or maintenance of epithelial cell apical/basal polarity

FB:FBrf0159915
PMID:12766944[19]

TAS: Traceable Author Statement

P

From FB

GO:0045200

establishment of neuroblast polarity

FB:FBrf0151280
PMID:12147138[13]

TAS: Traceable Author Statement

P

From FB

GO:0045746

negative regulation of Notch signaling pathway

FB:FBrf0158820
PMID:12725738[15]

IGI: Inferred from Genetic Interaction

FB:FBgn0004647

P

From FB

GO:0048730

epidermis morphogenesis

FB:FBrf0211705
PMID:20736316[29]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0051668

localization within membrane

FB:FBrf0188062
PMID:15901829[30]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0051726

regulation of cell cycle

FB:FBrf0159915
PMID:12766944[19]

NAS: Non-traceable Author Statement

P

From FB

GO:0055059

asymmetric neuroblast division

FB:FBrf0209035
PMID:19690050[31]

IGI: Inferred from Genetic Interaction

FB:FBgn0004177

P

From FB

GO:0090163

establishment of epithelial cell planar polarity

FB:FBrf0211705
PMID:20736316[29]

IMP: Inferred from Mutant Phenotype

P

From FB


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Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 Gibson MC & Perrimon N (2003) Apicobasal polarization: epithelial form and function. Curr Opin Cell Biol 15: 747-52 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Tepass U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet 35: 747-84 PubMed GONUTS page
  3. ↑ 3.0 3.1 Klämbt C & Schmidt O (1986) Developmental expression and tissue distribution of the lethal (2) giant larvae protein of Drosophila melanogaster. EMBO J 5: 2955-61 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Ohshiro T et al. (2000) Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature 408: 593-6 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Peng CY et al. (2000) The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature 408: 596-600 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 Bilder D et al. (2000) Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289: 113-6 PubMed GONUTS page
  7. ↑ 7.0 7.1 Noselli S & Agnès F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr Opin Genet Dev 9: 466-72 PubMed GONUTS page
  8. ↑ Médina E et al. (2002) Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells. Biol Cell 94: 305-13 PubMed GONUTS page
  9. ↑ 9.0 9.1 Bloor JW & Kiehart DP (2001) zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. Dev Biol 239: 215-28 PubMed GONUTS page
  10. ↑ 10.0 10.1 Arquier N et al. (2001) The Drosophila tumor suppressor gene lethal(2)giant larvae is required for the emission of the Decapentaplegic signal. Development 128: 2209-20 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 Lloyd TE et al. (2000) A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron 26: 45-50 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 Tian AG & Deng WM (2008) Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development 135: 463-71 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 13.3 13.4 Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
  14. ↑ Betschinger J et al. (2006) Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124: 1241-53 PubMed GONUTS page
  15. ↑ 15.0 15.1 Justice N et al. (2003) Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage. Curr Biol 13: 778-83 PubMed GONUTS page
  16. ↑ Caruana G (2002) Genetic studies define MAGUK proteins as regulators of epithelial cell polarity. Int J Dev Biol 46: 511-8 PubMed GONUTS page
  17. ↑ Wedlich D (2002) The polarising role of cell adhesion molecules in early development. Curr Opin Cell Biol 14: 563-8 PubMed GONUTS page
  18. ↑ Albertson R & Doe CQ (2003) Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat Cell Biol 5: 166-70 PubMed GONUTS page
  19. ↑ 19.0 19.1 19.2 Humbert P et al. (2003) Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25: 542-53 PubMed GONUTS page
  20. ↑ 20.0 20.1 20.2 Farkas R & Mechler BM (2000) The timing of drosophila salivary gland apoptosis displays an l(2)gl-dose response. Cell Death Differ 7: 89-101 PubMed GONUTS page
  21. ↑ Tamori Y et al. (2010) Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol 8: e1000422 PubMed GONUTS page
  22. ↑ Kaplan NA et al. (2009) Epithelial polarity: interactions between junctions and apical-basal machinery. Genetics 183: 897-904 PubMed GONUTS page
  23. ↑ 23.0 23.1 Schaefer M & Knoblich JA (2001) Protein localization during asymmetric cell division. Exp Cell Res 271: 66-74 PubMed GONUTS page
  24. ↑ 24.0 24.1 Betschinger J et al. (2003) The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature 422: 326-30 PubMed GONUTS page
  25. ↑ Bardin AJ et al. (2004) Asymmetric localization and function of cell-fate determinants: a fly's view. Curr Opin Neurobiol 14: 6-14 PubMed GONUTS page
  26. ↑ Petritsch C et al. (2003) The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Dev Cell 4: 273-81 PubMed GONUTS page
  27. ↑ Tuxworth R & Chia W (2003) Asymmetric cell division: Miranda chauffeured by Jaguar? Mol Cell 11: 288-9 PubMed GONUTS page
  28. ↑ Johnston LA & Gallant P (2002) Control of growth and organ size in Drosophila. Bioessays 24: 54-64 PubMed GONUTS page
  29. ↑ 29.0 29.1 Kaplan NA & Tolwinski NS (2010) Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis. J Cell Sci 123: 3157-65 PubMed GONUTS page
  30. ↑ Roegiers F et al. (2005) Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol Biol Cell 16: 3480-7 PubMed GONUTS page
  31. ↑ Ogawa H et al. (2009) Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions. J Cell Sci 122: 3242-9 PubMed GONUTS page
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