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FB:kuz
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | kuz ( synonyms: 11410, 34Da, ADAM10, BG:DS07660.3, CG7147, CT22079, GS11410, Kuz, Kuzbanian, br38, kuzbaninan, l(2)03782, l(2)34Da, l(2)br38, l(2)c00136, l(2)k01403, l34Da, lethal (2) c00136 ) | |
| Protein Name(s) | kuzbanian, | |
| External Links | ||
| FB | FBgn0259984 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003007 |
heart morphogenesis |
FB:FBrf0195313 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0004222 |
metalloendopeptidase activity |
FB:FBrf0096030 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004647 |
F |
From FB |
||
| GO:0004222 |
metalloendopeptidase activity |
FB:FBrf0096030 |
ISS: Inferred from Sequence or Structural Similarity |
MGI:MGI:109548 |
F |
From FB |
||
| GO:0006508 |
proteolysis |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0006911 |
phagocytosis, engulfment |
FB:FBrf0191376 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007219 |
Notch signaling pathway |
FB:FBrf0156161 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007220 |
Notch receptor processing |
FB:FBrf0099884 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0001169 |
P |
From FB |
||
| GO:0007220 |
Notch receptor processing |
FB:FBrf0099884 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004197 |
P |
From FB |
||
| GO:0007220 |
Notch receptor processing |
FB:FBrf0099884 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0004647 |
P |
From FB |
||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0191839 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007400 |
neuroblast fate determination |
FB:FBrf0209288 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0007411 |
axon guidance |
FB:FBrf0211121 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007417 |
central nervous system development |
FB:FBrf0159256 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007519 |
skeletal muscle tissue development |
FB:FBrf0195313 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008270 |
zinc ion binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0008347 |
glial cell migration |
FB:FBrf0191976 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030516 |
regulation of axon extension |
FB:FBrf0159256 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0035051 |
cardiac cell differentiation |
FB:FBrf0195313 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035386 |
regulation of Roundabout signaling pathway |
FB:FBrf0211121 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0010333 |
P |
From FB |
||
| GO:0048542 |
lymph gland development |
FB:FBrf0195313 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0060537 |
muscle tissue development |
FB:FBrf0195313 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0061320 |
pericardial nephrocyte differentiation |
FB:FBrf0195313 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Albrecht S et al. (2006) The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster. Mech Dev 123: 372-87 PubMed GONUTS page
- ↑ 2.0 2.1 Pan D & Rubin GM (1997) Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 90: 271-80 PubMed GONUTS page
- ↑ Stroschein-Stevenson SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol 4: e4 PubMed GONUTS page
- ↑ Kadesch T (2000) Notch signaling: a dance of proteins changing partners. Exp Cell Res 260: 1-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Sotillos S et al. (1997) The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Development 124: 4769-79 PubMed GONUTS page
- ↑ Wang X et al. (2007) Spatially localized Kuzbanian required for specific activation of Notch during border cell migration. Dev Biol 301: 532-40 PubMed GONUTS page
- ↑ Udolph G et al. (2009) On the roles of Notch, Delta, kuzbanian, and inscuteable during the development of Drosophila embryonic neuroblast lineages. Dev Biol 336: 156-68 PubMed GONUTS page
- ↑ 8.0 8.1 Coleman HA et al. (2010) The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline. Development 137: 2417-26 PubMed GONUTS page
- ↑ 9.0 9.1 McFarlane S (2003) Metalloproteases: carving out a role in axon guidance. Neuron 37: 559-62 PubMed GONUTS page
- ↑ Edenfeld G et al. (2007) Notch and Numb are required for normal migration of peripheral glia in Drosophila. Dev Biol 301: 27-37 PubMed GONUTS page
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