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FB:inaD

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) inaD ( synonyms: CG3504, INAD, Ina-D, InaD, Inactivation no afterpotential D, inactivation, no after-depolarization, inactivation-no after potential D, inactivation-no-afterpotential D, inactivation-no-afterpotential-D )
Protein Name(s) inactivation no afterpotential D,
External Links
FB FBgn0001263

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005198

structural molecule activity

FB:FBrf0096480
PMID:9230432[1]

IMP: Inferred from Mutant Phenotype

F

From FB

GO:0005198

structural molecule activity

FB:FBrf0099512
PMID:9356510[2]

IDA: Inferred from Direct Assay

F

From FB

GO:0005198

structural molecule activity

FB:FBrf0099512
PMID:9356510[2]

IMP: Inferred from Mutant Phenotype

F

From FB

GO:0005515

protein binding

FB:FBrf0136982
PMID:11342563[3]

IPI: Inferred from Physical Interaction

UniProtKB:P13677

F

From FB

GO:0005516

calmodulin binding

FB:FBrf0123143
PMID:10611962[4]

TAS: Traceable Author Statement

F

From FB

GO:0005516

calmodulin binding

FB:FBrf0141625
PMID:11707492[5]

TAS: Traceable Author Statement

F

From FB

GO:0005886

plasma membrane

FB:FBrf0210975

IDA: Inferred from Direct Assay

C

From FB

GO:0007602

phototransduction

FB:FBrf0080387
PMID:7826638[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007602

phototransduction

FB:FBrf0087705
PMID:8630257[7]

IPI: Inferred from Physical Interaction

FB:FBgn0003861

P

From FB

GO:0007602

phototransduction

FB:FBrf0096480
PMID:9230432[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007602

phototransduction

FB:FBrf0123143
PMID:10611962[4]

NAS: Non-traceable Author Statement

P

From FB

GO:0008104

protein localization

FB:FBrf0141625
PMID:11707492[5]

TAS: Traceable Author Statement

P

From FB

GO:0016027

inaD signaling complex

FB:FBrf0091374
PMID:9010208[8]

IPI: Inferred from Physical Interaction

FB:FBgn0002940

C

From FB

GO:0016027

inaD signaling complex

FB:FBrf0091374
PMID:9010208[8]

IPI: Inferred from Physical Interaction

FB:FBgn0003861

C

From FB

GO:0016027

inaD signaling complex

FB:FBrf0096480
PMID:9230432[1]

IPI: Inferred from Physical Interaction

FB:FBgn0003861

C

From FB

GO:0016027

inaD signaling complex

FB:FBrf0096480
PMID:9230432[1]

IPI: Inferred from Physical Interaction

FB:FBgn0004784

C

From FB

GO:0016027

inaD signaling complex

FB:FBrf0096480
PMID:9230432[1]

IPI: Inferred from Physical Interaction

FB:FBgn0262738

C

From FB

GO:0016027

inaD signaling complex

FB:FBrf0123143
PMID:10611962[4]

TAS: Traceable Author Statement

C

From FB

GO:0016027

inaD signaling complex

FB:FBrf0160593
PMID:12765677[9]

TAS: Traceable Author Statement

C

From FB

GO:0016028

rhabdomere

FB:FBrf0147176
PMID:11931743[10]

IDA: Inferred from Direct Assay

C

From FB

GO:0016028

rhabdomere

FB:FBrf0190947
PMID:16301334[11]

IDA: Inferred from Direct Assay

C

From FB

GO:0016028

rhabdomere

FB:FBrf0211062
PMID:20404479[12]

IDA: Inferred from Direct Assay

C

From FB

GO:0016059

deactivation of rhodopsin mediated signaling

FB:FBrf0080387
PMID:7826638[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0017022

myosin binding

FB:FBrf0141625
PMID:11707492[5]

TAS: Traceable Author Statement

F

From FB

GO:0030159

receptor signaling complex scaffold activity

FB:FBrf0141625
PMID:11707492[5]

TAS: Traceable Author Statement

F

From FB

GO:0031473

myosin III binding

FB:FBrf0108298
PMID:10321249[13]

IPI: Inferred from Physical Interaction

FB:FBgn0002938

F

From FB

GO:0050962

detection of light stimulus involved in sensory perception

FB:FBrf0192668
PMID:16914683[14]

IMP: Inferred from Mutant Phenotype

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 Tsunoda S et al. (1997) A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature 388: 243-9 PubMed GONUTS page
  2. 2.0 2.1 Shieh BH et al. (1997) Association of INAD with NORPA is essential for controlled activation and deactivation of Drosophila phototransduction in vivo. Proc Natl Acad Sci U S A 94: 12682-7 PubMed GONUTS page
  3. Kumar R & Shieh BH (2001) The second PDZ domain of INAD is a type I domain involved in binding to eye protein kinase C. Mutational analysis and naturally occurring variants. J Biol Chem 276: 24971-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 Montell C (1999) Visual transduction in Drosophila. Annu Rev Cell Dev Biol 15: 231-68 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Hardie RC (2001) Phototransduction in Drosophila melanogaster. J Exp Biol 204: 3403-9 PubMed GONUTS page
  6. 6.0 6.1 Shieh BH & Niemeyer B (1995) A novel protein encoded by the InaD gene regulates recovery of visual transduction in Drosophila. Neuron 14: 201-10 PubMed GONUTS page
  7. Shieh BH & Zhu MY (1996) Regulation of the TRP Ca2+ channel by INAD in Drosophila photoreceptors. Neuron 16: 991-8 PubMed GONUTS page
  8. 8.0 8.1 Chevesich J et al. (1997) Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex. Neuron 18: 95-105 PubMed GONUTS page
  9. Harteneck C (2003) Proteins modulating TRP channel function. Cell Calcium 33: 303-10 PubMed GONUTS page
  10. Bähner M et al. (2002) Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current. Neuron 34: 83-93 PubMed GONUTS page
  11. Wang T et al. (2005) Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel. J Cell Biol 171: 685-94 PubMed GONUTS page
  12. Sanxaridis PD & Tsunoda S (2010) A forward genetic screen in Drosophila melanogaster to identify mutations affecting INAD localization in photoreceptor cells. Fly (Austin) 4: 95-103 PubMed GONUTS page
  13. Wes PD et al. (1999) Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD. Nat Neurosci 2: 447-53 PubMed GONUTS page
  14. Popescu DC et al. (2006) Scaffolding protein INAD regulates deactivation of vision by promoting phosphorylation of transient receptor potential by eye protein kinase C in Drosophila. J Neurosci 26: 8570-7 PubMed GONUTS page
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