FB:imd

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005515	protein binding	FB:FBrf0205806 PMID:18688280^[1]	IPI: Inferred from Physical Interaction	FB:FBgn0034647	F	From FB
	GO:0005622	intracellular	FB:FBrf0167392 PMID:14557290^[2]	NAS: Non-traceable Author Statement		C	From FB
	GO:0006952	defense response	FB:FBrf0127230 PMID:10793472^[3]	TAS: Traceable Author Statement		P	From FB
	GO:0006952	defense response	FB:FBrf0133282	NAS: Non-traceable Author Statement		P	From FB
	GO:0006955	immune response	FB:FBrf0128398 PMID:10811906^[4]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0006959	humoral immune response	FB:FBrf0086971 PMID:8861100^[5]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0006963	positive regulation of antibacterial peptide biosynthetic process	FB:FBrf0100747 PMID:9510254^[6]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0006963	positive regulation of antibacterial peptide biosynthetic process	FB:FBrf0110270 PMID:10369678^[7]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0007165	signal transduction	FB:FBrf0133282	NAS: Non-traceable Author Statement		P	From FB
	GO:0007399	nervous system development	FB:FBrf0200690 PMID:17376868^[8]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0009617	response to bacterium	FB:FBrf0133535	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0009617	response to bacterium	FB:FBrf0155688 PMID:12530956^[9]	NAS: Non-traceable Author Statement		P	From FB
	GO:0019730	antimicrobial humoral response	FB:FBrf0090665 PMID:8808632^[10]	IGI: Inferred from Genetic Interaction	FB:FBgn0262473	P	From FB
	GO:0019730	antimicrobial humoral response	FB:FBrf0190362 PMID:16163390^[11]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0019731	antibacterial humoral response	FB:FBrf0084125 PMID:7568155^[12]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0019731	antibacterial humoral response	FB:FBrf0086971 PMID:8861100^[5]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0035556	intracellular signal transduction	FB:FBrf0174342 PMID:15032585^[13]	TAS: Traceable Author Statement		P	From FB
	GO:0042742	defense response to bacterium	FB:FBrf0141068 PMID:11283698^[14]	TAS: Traceable Author Statement		P	From FB
	GO:0045087	innate immune response	FB:FBrf0188361 PMID:15797611^[15]	NAS: Non-traceable Author Statement		P	From FB
	GO:0045089	positive regulation of innate immune response	FB:FBrf0201495 PMID:18066067^[16]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0050829	defense response to Gram-negative bacterium	FB:FBrf0167392 PMID:14557290^[2]	TAS: Traceable Author Statement		P	From FB
	GO:0050829	defense response to Gram-negative bacterium	FB:FBrf0174342 PMID:15032585^[13]	TAS: Traceable Author Statement		P	From FB
	GO:0050829	defense response to Gram-negative bacterium	FB:FBrf0179043 PMID:15199954^[17]	TAS: Traceable Author Statement		P	From FB
	GO:0061057	peptidoglycan recognition protein signaling pathway	FB:FBrf0133276 PMID:11269502^[18]	IMP: Inferred from Mutant Phenotype		P	From FB
	GO:0070513	death domain binding	FB:FBrf0152075 PMID:12433364^[19]	IPI: Inferred from Physical Interaction	FB:FBgn0038928	F	From FB
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Aggarwal K et al. (2008) Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway. PLoS Pathog 4: e1000120 PubMed GONUTS page
↑ ^2.0 ^2.1 Janssens S & Beyaert R (2003) Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 16: 637-46 PubMed GONUTS page
↑ Meister M et al. (2000) The antimicrobial host defense of Drosophila. Curr Top Microbiol Immunol 248: 17-36 PubMed GONUTS page
↑ Bernal A & Kimbrell DA (2000) Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity. Proc Natl Acad Sci U S A 97: 6019-24 PubMed GONUTS page
↑ ^5.0 ^5.1 Corbo JC & Levine M (1996) Characterization of an immunodeficiency mutant in Drosophila. Mech Dev 55: 211-20 PubMed GONUTS page
↑ Wu LP & Anderson KV (1998) Regulated nuclear import of Rel proteins in the Drosophila immune response. Nature 392: 93-7 PubMed GONUTS page
↑ Manfruelli P et al. (1999) A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. EMBO J 18: 3380-91 PubMed GONUTS page
↑ Koizumi K et al. (2007) RNA interference screen to identify genes required for Drosophila embryonic nervous system development. Proc Natl Acad Sci U S A 104: 5626-31 PubMed GONUTS page
↑ Silverman N (2003) Flies kNOw how to signal. Dev Cell 4: 5-6 PubMed GONUTS page
↑ Lemaitre B et al. (1996) The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86: 973-83 PubMed GONUTS page
↑ Kleino A et al. (2005) Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway. EMBO J 24: 3423-34 PubMed GONUTS page
↑ Lemaitre B et al. (1995) A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc Natl Acad Sci U S A 92: 9465-9 PubMed GONUTS page
↑ ^13.0 ^13.1 Brennan CA & Anderson KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu Rev Immunol 22: 457-83 PubMed GONUTS page
↑ Kimbrell DA & Beutler B (2001) The evolution and genetics of innate immunity. Nat Rev Genet 2: 256-67 PubMed GONUTS page
↑ Kwiatkowski DP (2005) The complexity of genetic variation in a simple immune system. Trends Genet 21: 197-9 PubMed GONUTS page
↑ Goto A et al. (2008) Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol 9: 97-104 PubMed GONUTS page
↑ Leclerc V & Reichhart JM (2004) The immune response of Drosophila melanogaster. Immunol Rev 198: 59-71 PubMed GONUTS page
↑ Leulier F et al. (2000) The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. EMBO Rep 1: 353-8 PubMed GONUTS page
↑ Naitza S et al. (2002) The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity 17: 575-81 PubMed GONUTS page

[PMID:18688280-0] Aggarwal K et al. (2008) Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway. PLoS Pathog 4: e1000120 PubMed GONUTS page

[PMID:14557290-1] 2.0 ^2.1 Janssens S & Beyaert R (2003) Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 16: 637-46 PubMed GONUTS page

[PMID:10793472-2] Meister M et al. (2000) The antimicrobial host defense of Drosophila. Curr Top Microbiol Immunol 248: 17-36 PubMed GONUTS page

[PMID:10811906-3] Bernal A & Kimbrell DA (2000) Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity. Proc Natl Acad Sci U S A 97: 6019-24 PubMed GONUTS page

[PMID:8861100-4] 5.0 ^5.1 Corbo JC & Levine M (1996) Characterization of an immunodeficiency mutant in Drosophila. Mech Dev 55: 211-20 PubMed GONUTS page

[PMID:9510254-5] Wu LP & Anderson KV (1998) Regulated nuclear import of Rel proteins in the Drosophila immune response. Nature 392: 93-7 PubMed GONUTS page

[PMID:10369678-6] Manfruelli P et al. (1999) A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. EMBO J 18: 3380-91 PubMed GONUTS page

[PMID:17376868-7] Koizumi K et al. (2007) RNA interference screen to identify genes required for Drosophila embryonic nervous system development. Proc Natl Acad Sci U S A 104: 5626-31 PubMed GONUTS page

[PMID:12530956-8] Silverman N (2003) Flies kNOw how to signal. Dev Cell 4: 5-6 PubMed GONUTS page

[PMID:8808632-9] Lemaitre B et al. (1996) The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86: 973-83 PubMed GONUTS page

[PMID:16163390-10] Kleino A et al. (2005) Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway. EMBO J 24: 3423-34 PubMed GONUTS page

[PMID:7568155-11] Lemaitre B et al. (1995) A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc Natl Acad Sci U S A 92: 9465-9 PubMed GONUTS page

[PMID:15032585-12] 13.0 ^13.1 Brennan CA & Anderson KV (2004) Drosophila: the genetics of innate immune recognition and response. Annu Rev Immunol 22: 457-83 PubMed GONUTS page

[PMID:11283698-13] Kimbrell DA & Beutler B (2001) The evolution and genetics of innate immunity. Nat Rev Genet 2: 256-67 PubMed GONUTS page

[PMID:15797611-14] Kwiatkowski DP (2005) The complexity of genetic variation in a simple immune system. Trends Genet 21: 197-9 PubMed GONUTS page

[PMID:18066067-15] Goto A et al. (2008) Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol 9: 97-104 PubMed GONUTS page

[PMID:15199954-16] Leclerc V & Reichhart JM (2004) The immune response of Drosophila melanogaster. Immunol Rev 198: 59-71 PubMed GONUTS page

[PMID:11269502-17] Leulier F et al. (2000) The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. EMBO Rep 1: 353-8 PubMed GONUTS page

[PMID:12433364-18] Naitza S et al. (2002) The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity 17: 575-81 PubMed GONUTS page

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Species (Taxon ID)	Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s)	imd ( synonyms: BG5, CG5576, IMD, Imd, Immune deficiency, Immunodeficiency, anon-WO0172774.166, immune deficient, shadok )
Protein Name(s)	immune deficiency,
External Links
FB	FBgn0013983

FB:imd

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