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FB:ik2

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) ik2 ( synonyms: 38D.31, APTX7, CG2615, DIK2, Dik2, DmIKKepsilon, DmIKKepsilon/dIK2, Dmik2, IK2, IKK, IKK-related kinase, IKKepsilon, Ik2, Ik2/DmIKK, apoptoxin 7, dIKK, dik2, l(2)38Ea, lethal (2) 38Ea )
Protein Name(s) IkappaB kinase-like 2,
External Links
FB FBgn0086657

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000902

cell morphogenesis

FB:FBrf0193419
PMID:16887350[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001578

microtubule bundle formation

FB:FBrf0209571
PMID:19917727[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0004672

protein kinase activity

FB:FBrf0132098
PMID:10908587[3]

NAS: Non-traceable Author Statement

F

From FB

GO:0004674

protein serine/threonine kinase activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q14164

F

From FB

GO:0005515

protein binding

FB:FBrf0194448
PMID:16887178[4]

IPI: Inferred from Physical Interaction

FB:FBgn0260635

F

From FB

GO:0005524

ATP binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR017441

F

From FB

GO:0006468

protein phosphorylation

FB:FBrf0116347

NAS: Non-traceable Author Statement

P

From FB

GO:0006468

protein phosphorylation

FB:FBrf0132098
PMID:10908587[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0006468

protein phosphorylation

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

P

From FB

GO:0006952

defense response

FB:FBrf0133282

NAS: Non-traceable Author Statement

P

From FB

GO:0007015

actin filament organization

FB:FBrf0193419
PMID:16887350[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007165

signal transduction

FB:FBrf0133282

NAS: Non-traceable Author Statement

P

From FB

GO:0008219

cell death

FB:FBrf0194448
PMID:16887178[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008384

IkappaB kinase activity

FB:FBrf0116347

NAS: Non-traceable Author Statement

F

From FB

GO:0008385

IkappaB kinase complex

FB:FBrf0116347

NAS: Non-traceable Author Statement

C

From FB

GO:0008407

chaeta morphogenesis

FB:FBrf0209571
PMID:19917727[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016322

neuron remodeling

FB:FBrf0207681
PMID:19329489[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035160

maintenance of epithelial integrity, open tracheal system

FB:FBrf0193419
PMID:16887350[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

FB:FBrf0194448
PMID:16887178[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0045035

sensory organ precursor cell division

FB:FBrf0209002
PMID:19822670[6]

IGI: Inferred from Genetic Interaction

FB:FBgn0260635

P

From FB

GO:0051493

regulation of cytoskeleton organization

FB:FBrf0205990
PMID:18796167[7]

IPI: Inferred from Physical Interaction

FB:FBgn0086362

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Oshima K et al. (2006) IKK epsilon regulates F actin assembly and interacts with Drosophila IAP1 in cellular morphogenesis. Curr Biol 16: 1531-7 PubMed GONUTS page
  2. 2.0 2.1 Bitan A et al. (2010) Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristle. Mol Cell Biol 30: 496-507 PubMed GONUTS page
  3. 3.0 3.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
  4. 4.0 4.1 4.2 Kuranaga E et al. (2006) Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell 126: 583-96 PubMed GONUTS page
  5. Lee HH et al. (2009) Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Proc Natl Acad Sci U S A 106: 6363-8 PubMed GONUTS page
  6. Koto A et al. (2009) Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development. J Cell Biol 187: 219-31 PubMed GONUTS page
  7. Dubin-Bar D et al. (2008) The Drosophila IKK-related kinase (Ik2) and Spindle-F proteins are part of a complex that regulates cytoskeleton organization during oogenesis. BMC Cell Biol 9: 51 PubMed GONUTS page
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