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FB:hpo
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | hpo ( synonyms: CG11228, Hippo, Hpo, MST, MST2, dMST ) | |
| Protein Name(s) | hippo, | |
| External Links | ||
| FB | FBgn0261456 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001654 |
eye development |
FB:FBrf0194704 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0002011 |
morphogenesis of an epithelial sheet |
FB:FBrf0193861 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0161987 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004702 |
receptor signaling protein serine/threonine kinase activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
EMBL:U28726 |
F |
From FB |
||
| GO:0004702 |
receptor signaling protein serine/threonine kinase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0192943 |
IPI: Inferred from Physical Interaction |
FB:FBgn0039055 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0192943 |
IPI: Inferred from Physical Interaction |
FB:FBgn0053193 |
F |
From FB |
||
| GO:0005515 |
protein binding |
FB:FBrf0210017 |
IPI: Inferred from Physical Interaction |
FB:FBgn0004583 |
F |
From FB |
||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005575 |
cellular component |
FB:FBrf0159398 |
ND: No biological Data available |
C |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0161987 |
IDA: Inferred from Direct Assay |
P |
From FB |
|||
| GO:0006915 |
apoptotic process |
FB:FBrf0161987 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006917 |
induction of apoptosis |
FB:FBrf0167938 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006917 |
induction of apoptosis |
FB:FBrf0194704 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008283 |
cell proliferation |
FB:FBrf0161987 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008283 |
cell proliferation |
FB:FBrf0173519 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0167938 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0010212 |
response to ionizing radiation |
FB:FBrf0192785 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0016301 |
kinase activity |
FB:FBrf0192785 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0042127 |
regulation of cell proliferation |
FB:FBrf0194704 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042771 |
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis |
FB:FBrf0192785 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0039044 |
P |
From FB |
||
| GO:0043066 |
negative regulation of apoptotic process |
FB:FBrf0173519 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
FB:FBrf0190294 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045464 |
R8 cell fate specification |
FB:FBrf0187233 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046621 |
negative regulation of organ growth |
FB:FBrf0173088 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0072089 |
stem cell proliferation |
FB:FBrf0212502 |
IDA: Inferred from Direct Assay |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Nolo R et al. (2006) The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr Biol 16: 1895-904 PubMed GONUTS page
- ↑ Thompson BJ & Cohen SM (2006) The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell 126: 767-74 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Wu S et al. (2003) hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114: 445-56 PubMed GONUTS page
- ↑ 4.0 4.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ 5.0 5.1 Polesello C et al. (2006) The Drosophila RASSF homolog antagonizes the hippo pathway. Curr Biol 16: 2459-65 PubMed GONUTS page
- ↑ Yu J et al. (2010) Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell 18: 288-99 PubMed GONUTS page
- ↑ 7.0 7.1 Udan RS et al. (2003) Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol 5: 914-20 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Colombani J et al. (2006) Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr Biol 16: 1453-8 PubMed GONUTS page
- ↑ Herz HM et al. (2006) vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis. Development 133: 1871-80 PubMed GONUTS page
- ↑ Mikeladze-Dvali T et al. (2005) The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. Cell 122: 775-87 PubMed GONUTS page
- ↑ Hafen E & Stocker H (2003) How are the sizes of cells, organs, and bodies controlled? PLoS Biol 1: E86 PubMed GONUTS page
- ↑ Ren F et al. (2010) Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A 107: 21064-9 PubMed GONUTS page
