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FB:hiw

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) hiw ( synonyms: CG32592, CG9041, CG9049, Highwire, Hiw )
Protein Name(s) highwire,
External Links
FB FBgn0030600

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004842

ubiquitin-protein ligase activity

FB:FBrf0198861

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q8WY64

F

From FB

GO:0005515

protein binding

FB:FBrf0175022
PMID:15046722[1]

IPI: Inferred from Physical Interaction

FB:FBgn0011655

F

From FB

GO:0005886

plasma membrane

FB:FBrf0128674
PMID:10839352[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0006914

autophagy

FB:FBrf0208921
PMID:19786572[3]

IDA: Inferred from Direct Assay

P

From FB

GO:0007628

adult walking behavior

FB:FBrf0155654
PMID:12490252[4]

NAS: Non-traceable Author Statement

P

From FB

GO:0008270

zinc ion binding

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR001841

F

From FB

GO:0008582

regulation of synaptic growth at neuromuscular junction

FB:FBrf0128674
PMID:10839352[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0008582

regulation of synaptic growth at neuromuscular junction

FB:FBrf0155654
PMID:12490252[4]

TAS: Traceable Author Statement

P

From FB

GO:0008582

regulation of synaptic growth at neuromuscular junction

FB:FBrf0191056
PMID:16237161[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016023

cytoplasmic membrane-bounded vesicle

FB:FBrf0128674
PMID:10839352[2]

IDA: Inferred from Direct Assay

C

From FB

GO:0016567

protein ubiquitination

FB:FBrf0198861

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q8WY64

P

From FB

GO:0030509

BMP signaling pathway

FB:FBrf0175022
PMID:15046722[1]

IPI: Inferred from Physical Interaction

FB:FBgn0011655

P

From FB

GO:0030514

negative regulation of BMP signaling pathway

FB:FBrf0175022
PMID:15046722[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0011655

P

From FB

GO:0030514

negative regulation of BMP signaling pathway

FB:FBrf0175022
PMID:15046722[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0024179

P

From FB

GO:0040011

locomotion

FB:FBrf0155654
PMID:12490252[4]

NAS: Non-traceable Author Statement

P

From FB

GO:0045886

negative regulation of synaptic growth at neuromuscular junction

FB:FBrf0175022
PMID:15046722[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0050808

synapse organization

FB:FBrf0208921
PMID:19786572[3]

IDA: Inferred from Direct Assay

P

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 McCabe BD et al. (2004) Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron 41: 891-905 PubMed GONUTS page
  2. 2.0 2.1 2.2 Wan HI et al. (2000) Highwire regulates synaptic growth in Drosophila. Neuron 26: 313-29 PubMed GONUTS page
  3. 3.0 3.1 Shen W & Ganetzky B (2009) Autophagy promotes synapse development in Drosophila. J Cell Biol 187: 71-9 PubMed GONUTS page
  4. 4.0 4.1 4.2 Strauss R (2002) The central complex and the genetic dissection of locomotor behaviour. Curr Opin Neurobiol 12: 633-8 PubMed GONUTS page
  5. Wu C et al. (2005) Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements. J Neurosci 25: 9557-66 PubMed GONUTS page
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