GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
FB:hep
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | hep ( synonyms: CG2190, CG4353, D-MKK7, DHEP/MKK7, DJNKK, DMKK7, HEP, HEP/MKK7, Hemipterous, Hep, Hep/Mkk7, JNK kinase, JNK-Kinase, JNK-kinase, JNKK, MAPKK, MKK7, Mitogen-activated protein kinase kinase 7, Mkk7, dJNKK, dMKK7, hem, hp, hrp, l(1)7P1, l(1)G0107, l(1)G0208 ) | |
| Protein Name(s) | hemipterous, | |
| External Links | ||
| FB | FBgn0010303 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000165 |
MAPK cascade |
FB:FBrf0128774 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0001736 |
establishment of planar polarity |
FB:FBrf0156094 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0004672 |
protein kinase activity |
FB:FBrf0083963 |
IDA: Inferred from Direct Assay |
F |
From FB |
|||
| GO:0004674 |
protein serine/threonine kinase activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0004702 |
receptor signaling protein serine/threonine kinase activity |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004708 |
MAP kinase kinase activity |
FB:FBrf0105495 |
ISS: Inferred from Sequence or Structural Similarity |
NCBI_gi:4826946 |
F |
From FB |
||
| GO:0004708 |
MAP kinase kinase activity |
FB:FBrf0124255 |
NAS: Non-traceable Author Statement |
F |
From FB |
|||
| GO:0004708 |
MAP kinase kinase activity |
FB:FBrf0128774 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0145123 |
IPI: Inferred from Physical Interaction |
FB:FBgn0044323 |
F |
From FB |
||
| GO:0005524 |
ATP binding |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
FB:FBrf0124255 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0110443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0006468 |
protein phosphorylation |
FB:FBrf0132098 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007254 |
JNK cascade |
FB:FBrf0090759 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007254 |
JNK cascade |
FB:FBrf0110443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007254 |
JNK cascade |
FB:FBrf0151280 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007298 |
border follicle cell migration |
FB:FBrf0201428 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0032006 |
P |
From FB |
||
| GO:0007391 |
dorsal closure |
FB:FBrf0090759 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0110443 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0124255 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0149002 |
NAS: Non-traceable Author Statement |
P |
From FB |
|||
| GO:0007391 |
dorsal closure |
FB:FBrf0155993 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007395 |
dorsal closure, spreading of leading edge cells |
FB:FBrf0083963 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007561 |
imaginal disc eversion |
FB:FBrf0180122 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007561 |
imaginal disc eversion |
FB:FBrf0192291 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008340 |
determination of adult lifespan |
FB:FBrf0167481 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008545 |
JUN kinase kinase activity |
FB:FBrf0083963 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From FB |
|||
| GO:0008545 |
JUN kinase kinase activity |
FB:FBrf0110443 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0008545 |
JUN kinase kinase activity |
FB:FBrf0144880 |
TAS: Traceable Author Statement |
F |
From FB |
|||
| GO:0009408 |
response to heat |
FB:FBrf0208375 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030032 |
lamellipodium assembly |
FB:FBrf0155993 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030381 |
chorion-containing eggshell pattern formation |
FB:FBrf0138279 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030424 |
axon |
FB:FBrf0209975 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0030707 |
ovarian follicle cell development |
FB:FBrf0128450 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0030707 |
ovarian follicle cell development |
FB:FBrf0189756 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0033500 |
carbohydrate homeostasis |
FB:FBrf0207766 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0034769 |
basement membrane disassembly |
FB:FBrf0192291 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0035006 |
melanization defense response |
FB:FBrf0192653 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0042060 |
wound healing |
FB:FBrf0183864 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0043507 |
positive regulation of JUN kinase activity |
FB:FBrf0188278 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0045610 |
regulation of hemocyte differentiation |
FB:FBrf0180639 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046330 |
positive regulation of JNK cascade |
FB:FBrf0189754 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046528 |
imaginal disc fusion |
FB:FBrf0180122 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046529 |
imaginal disc fusion, thorax closure |
FB:FBrf0137174 |
TAS: Traceable Author Statement |
P |
From FB |
|||
| GO:0046843 |
dorsal appendage formation |
FB:FBrf0138279 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046844 |
micropyle formation |
FB:FBrf0138279 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046847 |
filopodium assembly |
FB:FBrf0155993 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048666 |
neuron development |
FB:FBrf0209975 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0048675 |
axon extension |
FB:FBrf0192599 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051017 |
actin filament bundle assembly |
FB:FBrf0155993 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0070328 |
triglyceride homeostasis |
FB:FBrf0207766 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0071243 |
cellular response to arsenic-containing substance |
FB:FBrf0189754 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0071276 |
cellular response to cadmium ion |
FB:FBrf0189754 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Martín-Blanco E (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22: 637-45 PubMed GONUTS page
- ↑ Mlodzik M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet 18: 564-71 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Glise B et al. (1995) hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83: 451-61 PubMed GONUTS page
- ↑ 4.0 4.1 Morrison DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J Cell Biol 150: F57-62 PubMed GONUTS page
- ↑ Chen HW et al. (2002) CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Mol Cell Biol 22: 1792-803 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Noselli S & Agnès F (1999) Roles of the JNK signaling pathway in Drosophila morphogenesis. Curr Opin Genet Dev 9: 466-72 PubMed GONUTS page
- ↑ 7.0 7.1 Riesgo-Escovar JR et al. (1996) The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev 10: 2759-68 PubMed GONUTS page
- ↑ Harden N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70: 181-203 PubMed GONUTS page
- ↑ Mathieu J et al. (2007) A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics 176: 1579-90 PubMed GONUTS page
- ↑ Van Aelst L & Symons M (2002) Role of Rho family GTPases in epithelial morphogenesis. Genes Dev 16: 1032-54 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 Kaltschmidt JA et al. (2002) Planar polarity and actin dynamics in the epidermis of Drosophila. Nat Cell Biol 4: 937-44 PubMed GONUTS page
- ↑ 12.0 12.1 Pastor-Pareja JC et al. (2004) Invasive cell behavior during Drosophila imaginal disc eversion is mediated by the JNK signaling cascade. Dev Cell 7: 387-99 PubMed GONUTS page
- ↑ 13.0 13.1 Srivastava A et al. (2007) Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion. Proc Natl Acad Sci U S A 104: 2721-6 PubMed GONUTS page
- ↑ Wang MC et al. (2003) JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell 5: 811-6 PubMed GONUTS page
- ↑ Stronach B & Perrimon N (2002) Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev 16: 377-87 PubMed GONUTS page
- ↑ Karpac J et al. (2009) JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell 8: 288-95 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 Suzanne M et al. (2001) The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. Dev Biol 237: 282-94 PubMed GONUTS page
- ↑ 18.0 18.1 Rallis A et al. (2010) Signal strength and signal duration define two distinct aspects of JNK-regulated axon stability. Dev Biol 339: 65-77 PubMed GONUTS page
- ↑ Dobens LL & Raftery LA (2000) Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells. Dev Dyn 218: 80-93 PubMed GONUTS page
- ↑ Jordan KC et al. (2006) Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. BMC Dev Biol 6: 16 PubMed GONUTS page
- ↑ 21.0 21.1 Hull-Thompson J et al. (2009) Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz. PLoS Genet 5: e1000460 PubMed GONUTS page
- ↑ Bidla G et al. (2007) Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger. J Cell Sci 120: 1209-15 PubMed GONUTS page
- ↑ Bosch M et al. (2005) JNK signaling pathway required for wound healing in regenerating Drosophila wing imaginal discs. Dev Biol 280: 73-86 PubMed GONUTS page
- ↑ Uhlirova M et al. (2005) Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. Proc Natl Acad Sci U S A 102: 13123-8 PubMed GONUTS page
- ↑ Zettervall CJ et al. (2004) A directed screen for genes involved in Drosophila blood cell activation. Proc Natl Acad Sci U S A 101: 14192-7 PubMed GONUTS page
- ↑ 26.0 26.1 26.2 Ryabinina OP et al. (2006) D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol 7: 7 PubMed GONUTS page
- ↑ Gibson MC & Schubiger G (2001) Drosophila peripodial cells, more than meets the eye? Bioessays 23: 691-7 PubMed GONUTS page
- ↑ Srahna M et al. (2006) A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol 4: e348 PubMed GONUTS page
