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FB:h

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) h ( synonyms: 8247, CG6494, H, HRY, Hairy, bHLHb39, bHLHc14, barrel, brr, dDr1, hry, l(3)08247, l(3)rM384 )
Protein Name(s) hairy,
External Links
FB FBgn0001168

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0076513
PMID:7958929[1]

IDA: Inferred from Direct Assay

P

From FB

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0107533
PMID:9892668[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0107533
PMID:9892668[2]

IPI: Inferred from Physical Interaction

FB:FBgn0001139

P

From FB

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0123593

NAS: Non-traceable Author Statement

P

From FB

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0131266
PMID:11105896[3]

TAS: Traceable Author Statement

P

From FB

GO:0000902

cell morphogenesis

FB:FBrf0155504
PMID:12526813[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0000978

RNA polymerase II core promoter proximal region sequence-specific DNA binding

FB:FBrf0076513
PMID:7958929[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0001078

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription

FB:FBrf0076513
PMID:7958929[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0001666

response to hypoxia

FB:FBrf0205954
PMID:18927626[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0005515

protein binding

FB:FBrf0107533
PMID:9892668[2]

IPI: Inferred from Physical Interaction

FB:FBgn0001139

F

From FB

GO:0005515

protein binding

FB:FBrf0107533
PMID:9892668[2]

IPI: Inferred from Physical Interaction

FB:FBgn0020496

F

From FB

GO:0005634

nucleus

FB:FBrf0123593

NAS: Non-traceable Author Statement

C

From FB

GO:0007366

periodic partitioning by pair rule gene

FB:FBrf0123593

NAS: Non-traceable Author Statement

P

From FB

GO:0007366

periodic partitioning by pair rule gene

FB:FBrf0125812
PMID:10611687[6]

TAS: Traceable Author Statement

P

From FB

GO:0007366

periodic partitioning by pair rule gene

FB:FBrf0158726
PMID:12717812[7]

NAS: Non-traceable Author Statement

P

From FB

GO:0007366

periodic partitioning by pair rule gene

FB:FBrf0179912
PMID:15382142[8]

TAS: Traceable Author Statement

P

From FB

GO:0007399

nervous system development

FB:FBrf0161619

TAS: Traceable Author Statement

P

From FB

GO:0007424

open tracheal system development

FB:FBrf0187390
PMID:15848387[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007431

salivary gland development

FB:FBrf0158826
PMID:12593813[10]

TAS: Traceable Author Statement

P

From FB

GO:0007431

salivary gland development

FB:FBrf0168046
PMID:14624839[11]

TAS: Traceable Author Statement

P

From FB

GO:0007435

salivary gland morphogenesis

FB:FBrf0155504
PMID:12526813[4]

IGI: Inferred from Genetic Interaction

FB:FBgn0261434

P

From FB

GO:0007435

salivary gland morphogenesis

FB:FBrf0155504
PMID:12526813[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007435

salivary gland morphogenesis

FB:FBrf0159337
PMID:12742168[12]

TAS: Traceable Author Statement

P

From FB

GO:0007460

R8 cell fate commitment

FB:FBrf0144824
PMID:11880339[13]

NAS: Non-traceable Author Statement

P

From FB

GO:0008134

transcription factor binding

FB:FBrf0109791
PMID:10433905[14]

IPI: Inferred from Physical Interaction

FB:FBgn0001139

F

From FB

GO:0008407

chaeta morphogenesis

FB:FBrf0123593

NAS: Non-traceable Author Statement

P

From FB

GO:0016044

cellular membrane organization

FB:FBrf0158826
PMID:12593813[10]

TAS: Traceable Author Statement

P

From FB

GO:0031323

regulation of cellular metabolic process

FB:FBrf0205954
PMID:18927626[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035239

tube morphogenesis

FB:FBrf0155504
PMID:12526813[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035289

posterior head segmentation

FB:FBrf0179912
PMID:15382142[8]

TAS: Traceable Author Statement

P

From FB

GO:0035290

trunk segmentation

FB:FBrf0179912
PMID:15382142[8]

TAS: Traceable Author Statement

P

From FB

GO:0045892

negative regulation of transcription, DNA-dependent

FB:FBrf0076138
PMID:7768186[15]

IDA: Inferred from Direct Assay

P

From FB

GO:0045892

negative regulation of transcription, DNA-dependent

FB:FBrf0141797
PMID:11691830[16]

TAS: Traceable Author Statement

P

From FB

GO:0045892

negative regulation of transcription, DNA-dependent

FB:FBrf0151319
PMID:12119094[17]

TAS: Traceable Author Statement

P

From FB

GO:0070888

E-box binding

FB:FBrf0076513
PMID:7958929[1]

IDA: Inferred from Direct Assay

F

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Van Doren M et al. (1994) Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete. Genes Dev 8: 2729-42 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Zhang H & Levine M (1999) Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo. Proc Natl Acad Sci U S A 96: 535-40 PubMed GONUTS page
  3. Canon J & Banerjee U (2000) Runt and Lozenge function in Drosophila development. Semin Cell Dev Biol 11: 327-36 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Myat MM & Andrew DJ (2002) Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane. Cell 111: 879-91 PubMed GONUTS page
  5. 5.0 5.1 Zhou D et al. (2008) Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. PLoS Genet 4: e1000221 PubMed GONUTS page
  6. Davis GK & Patel NH (1999) The origin and evolution of segmentation. Trends Cell Biol 9: M68-72 PubMed GONUTS page
  7. Davis GK & Patel NH (2003) Playing by pair-rules? Bioessays 25: 425-9 PubMed GONUTS page
  8. 8.0 8.1 8.2 Peel A (2004) The evolution of arthropod segmentation mechanisms. Bioessays 26: 1108-16 PubMed GONUTS page
  9. Myat MM et al. (2005) A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila trachea. Dev Biol 281: 38-52 PubMed GONUTS page
  10. 10.0 10.1 Sudarsan V (2003) Tube morphogenesis: no pipe dream in Drosophila. Curr Biol 13: R131-3 PubMed GONUTS page
  11. Nelson WJ (2003) Tube morphogenesis: closure, but many openings remain. Trends Cell Biol 13: 615-21 PubMed GONUTS page
  12. Abrams EW et al. (2003) Constructing an organ: the Drosophila salivary gland as a model for tube formation. Trends Cell Biol 13: 247-54 PubMed GONUTS page
  13. Frankfort BJ & Mardon G (2002) R8 development in the Drosophila eye: a paradigm for neural selection and differentiation. Development 129: 1295-306 PubMed GONUTS page
  14. Goldstein RE et al. (1999) Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho. Development 126: 3747-55 PubMed GONUTS page
  15. Tsai C & Gergen P (1995) Pair-rule expression of the Drosophila fushi tarazu gene: a nuclear receptor response element mediates the opposing regulatory effects of runt and hairy. Development 121: 453-62 PubMed GONUTS page
  16. Courey AJ & Jia S (2001) Transcriptional repression: the long and the short of it. Genes Dev 15: 2786-96 PubMed GONUTS page
  17. Calleja M et al. (2002) How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila. Gene 292: 1-12 PubMed GONUTS page
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