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FB:gt

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) gt ( synonyms: CG7952, EG:BACH7M4.5, GIAN_DROME, GT, Giant, Gt, l(1)3Aa, l(1)giant )
Protein Name(s) giant,
External Links
FB FBgn0001150

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0055919
PMID:1576969[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0125319
PMID:10644409[2]

IDA: Inferred from Direct Assay

P

From FB

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0141797
PMID:11691830[3]

TAS: Traceable Author Statement

P

From FB

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

FB:FBrf0156773

NAS: Non-traceable Author Statement

P

From FB

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

FB:FBrf0055919
PMID:1576969[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

FB:FBrf0125319
PMID:10644409[2]

IDA: Inferred from Direct Assay

F

From FB

GO:0003677

DNA binding

FB:FBrf0156773

NAS: Non-traceable Author Statement

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q10587

F

From FB

GO:0003700

sequence-specific DNA binding transcription factor activity

FB:FBrf0205197
PMID:18271625[4]

IDA: Inferred from Direct Assay

F

From FB

GO:0003705

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

FB:FBrf0125319
PMID:10644409[2]

IDA: Inferred from Direct Assay

F

From FB

GO:0005634

nucleus

FB:FBrf0055919
PMID:1576969[1]

IDA: Inferred from Direct Assay

C

From FB

GO:0005634

nucleus

FB:FBrf0105495

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q10587

C

From FB

GO:0005634

nucleus

FB:FBrf0156773

NAS: Non-traceable Author Statement

C

From FB

GO:0006911

phagocytosis, engulfment

FB:FBrf0191376
PMID:16336044[5]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007354

zygotic determination of anterior/posterior axis, embryo

FB:FBrf0141797
PMID:11691830[3]

NAS: Non-traceable Author Statement

P

From FB

GO:0007354

zygotic determination of anterior/posterior axis, embryo

FB:FBrf0179912
PMID:15382142[6]

TAS: Traceable Author Statement

P

From FB

GO:0007362

terminal region determination

FB:FBrf0054989
PMID:1905816[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0003733

P

From FB

GO:0007381

specification of segmental identity, labial segment

FB:FBrf0204829
PMID:18493063[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007411

axon guidance

FB:FBrf0212090
PMID:20816678[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007431

salivary gland development

FB:FBrf0139594
PMID:11598957[10]

TAS: Traceable Author Statement

P

From FB

GO:0008293

torso signaling pathway

FB:FBrf0054989
PMID:1905816[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0003733

P

From FB

GO:0008361

regulation of cell size

FB:FBrf0212090
PMID:20816678[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0010468

regulation of gene expression

FB:FBrf0055919
PMID:1576969[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035271

ring gland development

FB:FBrf0179777
PMID:15385159[11]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035271

ring gland development

FB:FBrf0212090
PMID:20816678[9]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035289

posterior head segmentation

FB:FBrf0179912
PMID:15382142[6]

TAS: Traceable Author Statement

P

From FB

GO:0040015

negative regulation of multicellular organism growth

FB:FBrf0208858
PMID:19778508[12]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042803

protein homodimerization activity

FB:FBrf0152056
PMID:12176927[13]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0043565

sequence-specific DNA binding

FB:FBrf0055919
PMID:1576969[1]

IDA: Inferred from Direct Assay

F

From FB

GO:0044324

regulation of transcription involved in anterior/posterior axis specification

FB:FBrf0125319
PMID:10644409[2]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0046982

protein heterodimerization activity

FB:FBrf0152056
PMID:12176927[13]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0046983

protein dimerization activity

FB:FBrf0174215

IEA: Inferred from Electronic Annotation

InterPro:IPR011700

F

From FB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 Capovilla M et al. (1992) The giant gene of Drosophila encodes a b-ZIP DNA-binding protein that regulates the expression of other segmentation gap genes. Development 114: 99-112 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Shimell MJ et al. (2000) Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene. Dev Biol 218: 38-52 PubMed GONUTS page
  3. 3.0 3.1 Courey AJ & Jia S (2001) Transcriptional repression: the long and the short of it. Genes Dev 15: 2786-96 PubMed GONUTS page
  4. Li XY et al. (2008) Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol 6: e27 PubMed GONUTS page
  5. Stroschein-Stevenson SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol 4: e4 PubMed GONUTS page
  6. 6.0 6.1 Peel A (2004) The evolution of arthropod segmentation mechanisms. Bioessays 26: 1108-16 PubMed GONUTS page
  7. 7.0 7.1 Strecker TR et al. (1991) Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo. Proc Natl Acad Sci U S A 88: 5824-8 PubMed GONUTS page
  8. Sanders LR et al. (2008) The Drosophila gap gene giant has an anterior segment identity function mediated through disconnected and teashirt. Genetics 179: 441-53 PubMed GONUTS page
  9. 9.0 9.1 9.2 Ghosh A et al. (2010) The Drosophila gap gene giant regulates ecdysone production through specification of the PTTH-producing neurons. Dev Biol 347: 271-8 PubMed GONUTS page
  10. Bradley PL et al. (2001) Organ formation in Drosophila: specification and morphogenesis of the salivary gland. Bioessays 23: 901-11 PubMed GONUTS page
  11. De Velasco B et al. (2004) Embryonic development of the Drosophila corpus cardiacum, a neuroendocrine gland with similarity to the vertebrate pituitary, is controlled by sine oculis and glass. Dev Biol 274: 280-94 PubMed GONUTS page
  12. Parrish JZ et al. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63: 788-802 PubMed GONUTS page
  13. 13.0 13.1 Fassler J et al. (2002) B-ZIP proteins encoded by the Drosophila genome: evaluation of potential dimerization partners. Genome Res 12: 1190-200 PubMed GONUTS page
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