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FB:gig
Contents |
| Species (Taxon ID) | Drosophila melanogaster (fruit fly) (taxon:7227) | |
| Gene Name(s) | gig ( synonyms: 6975, C1, CG6975, Gigas, ME 109, TSC2, Tsc2, Tsc2/gig, Tuberous sclerosis complex 2, dTSC2, dTsc2, l(3)109, lethal(3)109, tsc2, tuberin ) | |
| Protein Name(s) | gigas, | |
| External Links | ||
| FB | FBgn0005198 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005096 |
GTPase activator activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
F |
From FB |
|||
| GO:0005515 |
protein binding |
FB:FBrf0204363 |
IPI: Inferred from Physical Interaction |
F |
From FB |
|||
| GO:0005737 |
cytoplasm |
FB:FBrf0152244 |
IDA: Inferred from Direct Assay |
C |
From FB |
|||
| GO:0006629 |
lipid metabolic process |
FB:FBrf0192579 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0026317 |
P |
From FB |
||
| GO:0006911 |
phagocytosis, engulfment |
FB:FBrf0191376 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0006974 |
response to DNA damage stimulus |
FB:FBrf0208272 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0007165 |
signal transduction |
FB:FBrf0152245 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0021796 |
P |
From FB |
||
| GO:0007584 |
response to nutrient |
FB:FBrf0152245 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0135684 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0026317 |
P |
From FB |
||
| GO:0008285 |
negative regulation of cell proliferation |
FB:FBrf0152244 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0008340 |
determination of adult lifespan |
FB:FBrf0179269 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0019900 |
kinase binding |
FB:FBrf0152245 |
IPI: Inferred from Physical Interaction |
FB:FBgn0021796 |
F |
From FB |
||
| GO:0030308 |
negative regulation of cell growth |
FB:FBrf0135684 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0026317 |
P |
From FB |
||
| GO:0030308 |
negative regulation of cell growth |
FB:FBrf0135684 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0030308 |
negative regulation of cell growth |
FB:FBrf0152244 |
IGI: Inferred from Genetic Interaction |
P |
From FB |
|||
| GO:0043547 |
positive regulation of GTPase activity |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0045792 |
negative regulation of cell size |
FB:FBrf0136941 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0026317 |
P |
From FB |
||
| GO:0045792 |
negative regulation of cell size |
FB:FBrf0209636 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046331 |
lateral inhibition |
FB:FBrf0214518 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0046621 |
negative regulation of organ growth |
FB:FBrf0136941 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0026317 |
P |
From FB |
||
| GO:0046627 |
negative regulation of insulin receptor signaling pathway |
FB:FBrf0136941 |
IGI: Inferred from Genetic Interaction |
FB:FBgn0013984 |
P |
From FB |
||
| GO:0048477 |
oogenesis |
FB:FBrf0107789 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051056 |
regulation of small GTPase mediated signal transduction |
FB:FBrf0174215 |
IEA: Inferred from Electronic Annotation |
P |
From FB |
|||
| GO:0051726 |
regulation of cell cycle |
FB:FBrf0107789 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0051726 |
regulation of cell cycle |
FB:FBrf0135684 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
|||
| GO:0071456 |
cellular response to hypoxia |
FB:FBrf0207151 |
IMP: Inferred from Mutant Phenotype |
P |
From FB |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hu J et al. (2008) WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev 22: 866-71 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Potter CJ et al. (2002) Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 4: 658-65 PubMed GONUTS page
- ↑ Gutierrez E et al. (2007) Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature 445: 275-80 PubMed GONUTS page
- ↑ Stroschein-Stevenson SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol 4: e4 PubMed GONUTS page
- ↑ Ravi D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet 5: e1000527 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Gao X et al. (2002) Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol 4: 699-704 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Tapon N et al. (2001) The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105: 345-55 PubMed GONUTS page
- ↑ Kapahi P et al. (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14: 885-90 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Gao X & Pan D (2001) TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev 15: 1383-92 PubMed GONUTS page
- ↑ Cully M et al. (2010) A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Mol Cell Biol 30: 481-95 PubMed GONUTS page
- ↑ 11.0 11.1 Ito N & Rubin GM (1999) gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 96: 529-39 PubMed GONUTS page
- ↑ Lee SJ et al. (2008) An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Mol Biol Cell 19: 4051-61 PubMed GONUTS page
