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FB:fz

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Contents

Species (Taxon ID) Drosophila melanogaster (fruit fly) (taxon:7227)
Gene Name(s) fz ( synonyms: CG17697, CG3646, DFZ1, DFz, DFz1, Dfz1, Dm Fz1, FZ, Frizzled, Frizzled 1, Frizzled1, Frz, Fz, Fz1, frazzled, frizzled 1, frizzled((1)), frz, fz1, fz((1)) )
Protein Name(s) frizzled,
External Links
FB FBgn0001085

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001736

establishment of planar polarity

FB:FBrf0111508
PMID:10490098[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001736

establishment of planar polarity

FB:FBrf0156094
PMID:12414186[2]

TAS: Traceable Author Statement

P

From FB

GO:0001736

establishment of planar polarity

FB:FBrf0179929
PMID:15475117[3]

TAS: Traceable Author Statement

P

From FB

GO:0001737

establishment of imaginal disc-derived wing hair orientation

FB:FBrf0111508
PMID:10490098[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001737

establishment of imaginal disc-derived wing hair orientation

FB:FBrf0134764
PMID:11239465[4]

IEP: Inferred from Expression Pattern

P

From FB

GO:0001737

establishment of imaginal disc-derived wing hair orientation

FB:FBrf0134764
PMID:11239465[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001737

establishment of imaginal disc-derived wing hair orientation

FB:FBrf0148937
PMID:12062069[5]

TAS: Traceable Author Statement

P

From FB

GO:0001737

establishment of imaginal disc-derived wing hair orientation

FB:FBrf0191849
PMID:16824922[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001738

morphogenesis of a polarized epithelium

FB:FBrf0190197
PMID:16326392[7]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0001745

compound eye morphogenesis

FB:FBrf0214595
PMID:21811578[8]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0004888

transmembrane signaling receptor activity

FB:FBrf0129744
PMID:10908591[9]

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0005886

plasma membrane

FB:FBrf0050626
PMID:2493583[10]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0005886

plasma membrane

FB:FBrf0051945
PMID:2174014[11]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0005886

plasma membrane

FB:FBrf0074100
PMID:8199049[12]

IDA: Inferred from Direct Assay

C

From FB

GO:0005886

plasma membrane

FB:FBrf0190364
PMID:16163385[13]

IDA: Inferred from Direct Assay

C

From FB

GO:0005887

integral to plasma membrane

FB:FBrf0084528
PMID:7555730[14]

TAS: Traceable Author Statement

C

From FB

GO:0005938

cell cortex

FB:FBrf0134764
PMID:11239465[4]

IDA: Inferred from Direct Assay

C

From FB

GO:0007156

homophilic cell adhesion

FB:FBrf0111508
PMID:10490098[1]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007163

establishment or maintenance of cell polarity

FB:FBrf0050626
PMID:2493583[10]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007163

establishment or maintenance of cell polarity

FB:FBrf0190364
PMID:16163385[13]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007164

establishment of tissue polarity

FB:FBrf0149002
PMID:12000787[15]

NAS: Non-traceable Author Statement

P

From FB

GO:0007164

establishment of tissue polarity

FB:FBrf0155643
PMID:12231350[16]

NAS: Non-traceable Author Statement

P

From FB

GO:0007165

signal transduction

FB:FBrf0129744
PMID:10908591[9]

ISS: Inferred from Sequence or Structural Similarity

P

From FB

GO:0007298

border follicle cell migration

FB:FBrf0200679
PMID:17652348[17]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007435

salivary gland morphogenesis

FB:FBrf0201960
PMID:17507403[18]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0007464

R3/R4 cell fate commitment

FB:FBrf0155643
PMID:12231350[16]

TAS: Traceable Author Statement

P

From FB

GO:0007464

R3/R4 cell fate commitment

FB:FBrf0156094
PMID:12414186[2]

NAS: Non-traceable Author Statement

P

From FB

GO:0007507

heart development

FB:FBrf0151249
PMID:12027431[19]

NAS: Non-traceable Author Statement

P

From FB

GO:0008104

protein localization

FB:FBrf0149002
PMID:12000787[15]

TAS: Traceable Author Statement

P

From FB

GO:0008104

protein localization

FB:FBrf0151527
PMID:12127767[20]

TAS: Traceable Author Statement

P

From FB

GO:0008105

asymmetric protein localization

FB:FBrf0155643
PMID:12231350[16]

TAS: Traceable Author Statement

P

From FB

GO:0008356

asymmetric cell division

FB:FBrf0191444
PMID:16617104[21]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016021

integral to membrane

FB:FBrf0051945
PMID:2174014[11]

NAS: Non-traceable Author Statement

C

From FB

GO:0016021

integral to membrane

FB:FBrf0123693

NAS: Non-traceable Author Statement

C

From FB

GO:0016021

integral to membrane

FB:FBrf0129744
PMID:10908591[9]

ISS: Inferred from Sequence or Structural Similarity

C

From FB

GO:0016055

Wnt receptor signaling pathway

FB:FBrf0104536
PMID:9671581[22]

TAS: Traceable Author Statement

P

From FB

GO:0016055

Wnt receptor signaling pathway

FB:FBrf0123693

ISS: Inferred from Sequence or Structural Similarity

P

From FB

GO:0016055

Wnt receptor signaling pathway

FB:FBrf0149002
PMID:12000787[15]

NAS: Non-traceable Author Statement

P

From FB

GO:0016318

ommatidial rotation

FB:FBrf0084528
PMID:7555730[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0016318

ommatidial rotation

FB:FBrf0149002
PMID:12000787[15]

TAS: Traceable Author Statement

P

From FB

GO:0016360

sensory organ precursor cell fate determination

FB:FBrf0132423
PMID:11146626[23]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0017147

Wnt-protein binding

FB:FBrf0123693

ISS: Inferred from Sequence or Structural Similarity

F

From FB

GO:0030010

establishment of cell polarity

FB:FBrf0134764
PMID:11239465[4]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0032231

regulation of actin filament bundle assembly

FB:FBrf0135688
PMID:11301004[24]

IGI: Inferred from Genetic Interaction

FB:FBgn0026181

P

From FB

GO:0035159

regulation of tube length, open tracheal system

FB:FBrf0209469
PMID:19956736[25]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0035317

imaginal disc-derived wing hair organization

FB:FBrf0135688
PMID:11301004[24]

IGI: Inferred from Genetic Interaction

FB:FBgn0000317

P

From FB

GO:0035317

imaginal disc-derived wing hair organization

FB:FBrf0135688
PMID:11301004[24]

IGI: Inferred from Genetic Interaction

FB:FBgn0003514

P

From FB

GO:0035317

imaginal disc-derived wing hair organization

FB:FBrf0135688
PMID:11301004[24]

IGI: Inferred from Genetic Interaction

FB:FBgn0005634

P

From FB

GO:0035317

imaginal disc-derived wing hair organization

FB:FBrf0135688
PMID:11301004[24]

IGI: Inferred from Genetic Interaction

FB:FBgn0014020

P

From FB

GO:0035317

imaginal disc-derived wing hair organization

FB:FBrf0135688
PMID:11301004[24]

IGI: Inferred from Genetic Interaction

FB:FBgn0026181

P

From FB

GO:0035320

imaginal disc-derived wing hair site selection

FB:FBrf0072458
PMID:7918095[26]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042067

establishment of ommatidial planar polarity

FB:FBrf0084528
PMID:7555730[14]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042067

establishment of ommatidial planar polarity

FB:FBrf0146910
PMID:11893338[27]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042067

establishment of ommatidial planar polarity

FB:FBrf0148937
PMID:12062069[5]

TAS: Traceable Author Statement

P

From FB

GO:0042067

establishment of ommatidial planar polarity

FB:FBrf0151712
PMID:12121634[28]

TAS: Traceable Author Statement

P

From FB

GO:0042067

establishment of ommatidial planar polarity

FB:FBrf0155643
PMID:12231350[16]

TAS: Traceable Author Statement

P

From FB

GO:0042067

establishment of ommatidial planar polarity

FB:FBrf0156198
PMID:12137730[29]

TAS: Traceable Author Statement

P

From FB

GO:0042067

establishment of ommatidial planar polarity

FB:FBrf0191849
PMID:16824922[6]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042067

establishment of ommatidial planar polarity

FB:FBrf0191945
PMID:16824921[30]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0042813

Wnt-activated receptor activity

FB:FBrf0104536
PMID:9671581[22]

TAS: Traceable Author Statement

F

From FB

GO:0042813

Wnt-activated receptor activity

FB:FBrf0190364
PMID:16163385[13]

IDA: Inferred from Direct Assay

F

From FB

GO:0045198

establishment of epithelial cell apical/basal polarity

FB:FBrf0155499
PMID:12540853[31]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0048675

axon extension

FB:FBrf0192599
PMID:17032066[32]

IMP: Inferred from Mutant Phenotype

P

From FB

GO:0060070

canonical Wnt receptor signaling pathway

FB:FBrf0190364
PMID:16163385[13]

IGI: Inferred from Genetic Interaction

FB:FBgn0004009

P

From FB

colocalizes_with

GO:0005768

endosome

FB:FBrf0190217
PMID:16459300[33]

IDA: Inferred from Direct Assay

C

From FB


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 Usui T et al. (1999) Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell 98: 585-95 PubMed GONUTS page
  2. ↑ 2.0 2.1 Mlodzik M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet 18: 564-71 PubMed GONUTS page
  3. ↑ Torban E et al. (2004) Van Gogh-like2 (Strabismus) and its role in planar cell polarity and convergent extension in vertebrates. Trends Genet 20: 570-7 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Strutt DI (2001) Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing. Mol Cell 7: 367-75 PubMed GONUTS page
  5. ↑ 5.0 5.1 Strutt H & Strutt D (2002) Planar polarity: photoreceptors on a high fat diet. Curr Biol 12: R384-5 PubMed GONUTS page
  6. ↑ 6.0 6.1 Klein TJ et al. (2006) CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila. Curr Biol 16: 1337-43 PubMed GONUTS page
  7. ↑ Classen AK et al. (2005) Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway. Dev Cell 9: 805-17 PubMed GONUTS page
  8. ↑ Kryuchkov M et al. (2011) Analysis of micro- and nano-structures of the corneal surface of Drosophila and its mutants by atomic force microscopy and optical diffraction. PLoS One 6: e22237 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Brody T & Cravchik A (2000) Drosophila melanogaster G protein-coupled receptors. J Cell Biol 150: F83-8 PubMed GONUTS page
  10. ↑ 10.0 10.1 Vinson CR et al. (1989) A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains. Nature 338: 263-4 PubMed GONUTS page
  11. ↑ 11.0 11.1 Adler PN et al. (1990) Molecular structure of frizzled, a Drosophila tissue polarity gene. Genetics 126: 401-16 PubMed GONUTS page
  12. ↑ Park WJ et al. (1994) The frizzled gene of Drosophila encodes a membrane protein with an odd number of transmembrane domains. Mech Dev 45: 127-37 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 13.3 Povelones M & Nusse R (2005) The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling. EMBO J 24: 3493-503 PubMed GONUTS page
  14. ↑ 14.0 14.1 14.2 Zheng L et al. (1995) frizzled regulates mirror-symmetric pattern formation in the Drosophila eye. Development 121: 3045-55 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 15.3 Van Aelst L & Symons M (2002) Role of Rho family GTPases in epithelial morphogenesis. Genes Dev 16: 1032-54 PubMed GONUTS page
  16. ↑ 16.0 16.1 16.2 16.3 Wedlich D (2002) The polarising role of cell adhesion molecules in early development. Curr Opin Cell Biol 14: 563-8 PubMed GONUTS page
  17. ↑ Bastock R & Strutt D (2007) The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis. Development 134: 3055-64 PubMed GONUTS page
  18. ↑ Harris KE & Beckendorf SK (2007) Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration. Development 134: 2017-25 PubMed GONUTS page
  19. ↑ Cripps RM & Olson EN (2002) Control of cardiac development by an evolutionarily conserved transcriptional network. Dev Biol 246: 14-28 PubMed GONUTS page
  20. ↑ Cadigan KM (2002) Wnt signaling--20 years and counting. Trends Genet 18: 340-2 PubMed GONUTS page
  21. ↑ Katanaev VL & Tomlinson A (2006) Dual roles for the trimeric G protein Go in asymmetric cell division in Drosophila. Proc Natl Acad Sci U S A 103: 6524-9 PubMed GONUTS page
  22. ↑ 22.0 22.1 Zhang J & Carthew RW (1998) Interactions between Wingless and DFz2 during Drosophila wing development. Development 125: 3075-85 PubMed GONUTS page
  23. ↑ Bellaïche Y et al. (2001) Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division. Nat Cell Biol 3: 50-7 PubMed GONUTS page
  24. ↑ 24.0 24.1 24.2 24.3 24.4 24.5 Winter CG et al. (2001) Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell 105: 81-91 PubMed GONUTS page
  25. ↑ Chung S et al. (2009) Serrano (sano) functions with the planar cell polarity genes to control tracheal tube length. PLoS Genet 5: e1000746 PubMed GONUTS page
  26. ↑ Adler PN et al. (1994) The cold-sensitive period for frizzled in the development of wing hair polarity ends prior to the start of hair morphogenesis. Mech Dev 46: 101-7 PubMed GONUTS page
  27. ↑ Yang CH et al. (2002) Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell 108: 675-88 PubMed GONUTS page
  28. ↑ McNeill H (2002) Planar polarity: location, location, location. Curr Biol 12: R449-51 PubMed GONUTS page
  29. ↑ Tree DR et al. (2002) A three-tiered mechanism for regulation of planar cell polarity. Semin Cell Dev Biol 13: 217-24 PubMed GONUTS page
  30. ↑ Strutt H et al. (2006) Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila. Curr Biol 16: 1329-36 PubMed GONUTS page
  31. ↑ Ma D et al. (2003) Fidelity in planar cell polarity signalling. Nature 421: 543-7 PubMed GONUTS page
  32. ↑ Srahna M et al. (2006) A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol 4: e348 PubMed GONUTS page
  33. ↑ Shimada Y et al. (2006) Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium. Dev Cell 10: 209-22 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/FB:fz"
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